Study finds aggressive glycemic control in diabetic CABG patients does not improve survival

Surgeons from Boston Medical Center (BMC) have found that in diabetic patients undergoing coronary artery bypass graft (CABG) surgery, aggressive glycemic control does not result in any significant improvement of clinical outcomes as compared with moderate control. The findings, to be presented at the 131st annual meeting of the American Surgical Association, also found the incidence of hypoglycemic events increased with aggressive glycemic control.

Currently, 40 percent of all patients undergoing CABG suffer from diabetes, and this number is quickly rising. Traditionally these patients have more complications following surgery, including greater risk of heart attacks, more wound infections and reduced long-term survival.

Maintaining serum glucose between 120-180 mg/dl with continuous insulin infusions decreases morbidity in undergoing CABG. Prior studies in surgical patients requiring prolonged ventilation suggest that aggressive glycemic control (less than 120 mg/dl) may improve survival. However, its effect in diabetic CABG patients is unknown.

Eighty-two diabetic patients undergoing CABG were prospectively randomized to receive either aggressive glycemic control or moderate glycemic control using continuous intravenous insulin solutions beginning at anesthesia and continuing for 18 hours after surgery.

According to BMC cardiothoracic surgeon Harold Lazar, MD, who authored the presentation, there was no difference in the incidence of major adverse effects between the two groups. "Aggressive glycemic control did not result in any significant improvement of than can be achieved with moderate control," said Lazar, who is also a professor of cardiothoracic surgery at Boston University School of Medicine "Although aggressive glycemic control did increase the incidence of hypoglycemic events, it did not result in an increased incidence of neurological events," he added.

Provided by Boston University Medical Center

not rated yet
add to favorites email to friend print save as pdf

Related Stories

Diabetes support -- actions speak louder than words

Sep 28, 2009

For physicians treating patients with diabetes, practical support is important in improving glycemic control. Researchers writing in the open access journal BMC Public Health found that setting goals and pro-active follow ...

Recommended for you

First case of Ebola confirmed in Mali

3 hours ago

Mali's health ministry on Thursday said the country had its first confirmed case of Ebola after a two-year-old girl who had recently been in Guinea tested positive for the virus.

New York confirms first Ebola case

3 hours ago

A doctor who recently returned to New York from treating Ebola patients in Guinea tested positive on Thursday for the deadly virus, the first confirmed case in the city, officials said.

User comments

Adjust slider to filter visible comments by rank

Display comments: newest first

tjavailable
not rated yet Apr 16, 2011
What I would like to add here is that after CABG the patients have to take certain precautions for eight to 12 weeks to reduce the risk of opening the incision.
First,patients need to avoid using their arms excessively,
Second,patients should avoid lifting anything in excess of 2-5kg. Finally,patients should avoid overhead activities with their hands,
To know more visit: heart-consult.com/articles/what-coronary-artery-bypass-graft