Long-term use of antibiotic to treat acne not associated with increased bacterial resistance

The prolonged use of tetracycline antibiotics commonly used to treat acne was associated with a reduced prevalence of StaphylococcuS. aureus bacteria and was not associated with increased resistance to the tetracycline antibiotics, according to a report posted online today that will appear in the August print issue of Archives of Dermatology.

StaphylococcuS. aureus is found in both hospital and community settings. "While S. aureus colonizes the skin, it can also be responsible for localized cutaneous infections and life-threatening systemic infections," the authors write as background information in the article. "At one time, it was sensitive to many antibiotics and . However, because of its ability to adapt to these therapies and become resistant, clinical scenarios now exist in which few therapeutic options remain to treat this organism. Therefore, methicillin-resistant S. aureus () has become commonplace."

Matthew Fanelli, M.D., and colleagues at the University of Pennsylvania School of Medicine, Philadelphia, conducted a survey study of patients treated for acne to determine the frequency of S. aureus colonization and to compare the susceptibility patterns between patients who are using antibiotics and those who are not using antibiotics. A total of 36 of the 83 patients in the study (43 percent) were colonized with S. aureus. Two of the 36 patients (6 percent) had MRSA; 20 (56 percent) had S. aureus solely in their throats; nine (25 percent) had S. aureus solely in their noses; and seven (19 percent) had S. aureus in both their noses and throats.

"Long-term use of antibiotics decreased the prevalence of S. aureus colonization by nearly 70 percent," the authors report. "A decreased rate of colonization was noted with the use of both oral and topical antibiotics."

"Fewer than 10 percent of the isolates of S. aureus were resistant to tetracyclines, the most commonly used antibiotic family to treat acne," they write. "Resistance to erythromycin and clindamycin was mostly prevalent among our isolates and was noted in the patients who did and did not use antibiotics."

The study results contradict current dogma about long-term use of antibiotics.

"Specifically, in our study, the prolonged use of antibiotics from the tetracycline class that are commonly used to treat acne lowered the prevalence of colonization by S. aureus and did not increase resistance to the antibiotics," the authors conclude. "Future research should be conducted with respect to other organisms and antibiotics."

More information: Arch Dermatol. Published online April 11, 2011. doi:10.1001/archdermatol.2011.67

add to favorites email to friend print save as pdf

Related Stories

MRSA head and neck infections increase among children

Jan 19, 2009

Rates of antibiotic-resistant head and neck infections increased in pediatric patients nationwide between 2001 and 2006, according to a report in the January issue of Archives of Otolaryngology-Head & Neck Surgery, one of ...

Bacteria build walls to withstand antibiotics

Nov 01, 2005

Antibiotic resistant bacteria, which are proliferating in hospitals and causing major headaches for physicians, cheat death by finding ways to fortify their cell walls against the deadly drugs. The question is: how? New res ...

Recommended for you

Sierra Leone: WHO too slow to help doc with Ebola

5 hours ago

Sierra Leone accused the World Health Organization on Monday of being "sluggish" in facilitating an evacuation of a doctor who died from Ebola before she could be sent out of the country for medical care.

Dutch doctors feared to have Ebola leave hospital

5 hours ago

Two Dutch doctors flown home from west Africa after fears they might have been contaminated with the killer Ebola virus have left hospital "in good health," their employer, the Lion Heart Medical Centre, said Monday.

Strategic self-sabotage? MRSA inhibits its own growth

10 hours ago

Scientists at the University of Western Ontario have uncovered a bacterial mystery. Against all logic, the most predominant strain of methicillin-resistant Staphylococcus aureus (MRSA) in North American produces an enzyme ...

US works to step up Ebola aid, but is it enough?

12 hours ago

The American strategy on Ebola is two-pronged: Step up desperately needed aid to West Africa and, in an unusual step, train U.S. doctors and nurses for volunteer duty in the outbreak zone. At home, the goal ...

User comments