Newer oral contraceptive as safe for gall bladder as older birth-control pills: research
Drospirenone, the top-selling oral contraceptive marketed as Yaz or Yasmin in the U.S. and Canada, doesn't carry any more risk of gall bladder disease than the older generation of birth control pills, despite claims by some consumers and lawyers in both countries, according to a new study by University of British Columbia and Vancouver Coastal Health Research Institute researcher Mahyar Etminan.
In the study, published today in the CMAJ (Canadian Medical Association Journal), Etminan and colleagues from McGill University and the University of Florida analyzed a database of health records for 2.7 million U.S. women using oral contraceptives over 18 months. He sought to determine whether there was a higher rate of gall bladder surgery or hospital admission for gall bladder disease among women using the relatively new drospirenone, compared to levonorgestrel, the oldest and historically most-prescribed oral contraceptive.
All oral contraceptive drugs carry a small increased risk of gall bladder disease; recent lawsuits allege dropsirenone's risk is greater than the others. Other allegations leveled against the drug by patients and lawyers include harmful effects on the heart and an increased risk of blood clots. This was the first published study to compare the gall bladder risks of the various birth control pills.
While the analysis found a small, statistically significant increased risk of gall bladder disease among users of dropsirenone as well as two other traditional oral contraceptives it is not great enough to be deemed clinically relevant or a cause for concern compared to levonorgestrel, says Etminan, a drug safety expert.
"There have been concerns about various risks of dropsirenone raised by consumers and their lawyers that have been covered by the news media, and which may in turn affect the decisions of physicians and their patients," says Etminan, a pharmacoepidemiologist at the Centre for Clinical Epidemiology & Evaluation at Vancouver Coastal Health Research Institute and an assistant professor in the Dept. of Medicine at UBC.
"This study should give women some reassurance that the drug is as safe as other contraceptives at least with regard to gall bladder disease, and women should weigh this against the increased risk of pregnancy that occurs when switching to another contraceptive drug," says Etminan.
Provided by University of British Columbia
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