Newer oral contraceptive as safe for gall bladder as older birth-control pills: research

Drospirenone, the top-selling oral contraceptive marketed as Yaz or Yasmin in the U.S. and Canada, doesn't carry any more risk of gall bladder disease than the older generation of birth control pills, despite claims by some consumers and lawyers in both countries, according to a new study by University of British Columbia and Vancouver Coastal Health Research Institute researcher Mahyar Etminan.

In the study, published today in the CMAJ (), Etminan and colleagues from McGill University and the University of Florida analyzed a database of for 2.7 million U.S. women using over 18 months. He sought to determine whether there was a higher rate of gall bladder surgery or for gall bladder disease among women using the relatively new drospirenone, compared to levonorgestrel, the oldest and historically most-prescribed oral contraceptive.

All oral contraceptive drugs carry a small increased risk of gall bladder disease; recent lawsuits allege dropsirenone's risk is greater than the others. Other allegations leveled against the drug by patients and lawyers include harmful effects on the heart and an increased risk of blood clots. This was the first published study to compare the gall bladder risks of the various birth control pills.

While the analysis found a small, statistically significant increased risk of gall bladder disease among users of dropsirenone – as well as two other traditional oral contraceptives – it is not great enough to be deemed clinically relevant or a cause for concern compared to levonorgestrel, says Etminan, a drug safety expert.

"There have been concerns about various risks of dropsirenone raised by consumers and their lawyers that have been covered by the news media, and which may in turn affect the decisions of physicians and their patients," says Etminan, a pharmacoepidemiologist at the Centre for Clinical Epidemiology & Evaluation at Vancouver Coastal Health Research Institute and an assistant professor in the Dept. of Medicine at UBC.

"This study should give women some reassurance that the drug is as safe as other contraceptives at least with regard to gall bladder disease, and women should weigh this against the increased risk of pregnancy that occurs when switching to another contraceptive drug," says Etminan.

add to favorites email to friend print save as pdf

Related Stories

New warning OK'd for birth control patch

Jan 21, 2008

The U.S. Food and Drug Administration has approved a warning for the Ortho Evra Contraceptive Transdermal Patch label concerning the risk of blood clots.

Recommended for you

Determine patient preferences by means of conjoint analysis

11 hours ago

The Conjoint Analysis (CA) method is in principle suitable to find out which preferences patients have regarding treatment goals. However, to widely use it in health economic evaluations, some (primarily methodological) issues ...

FDA approves hard-to-abuse narcotic painkiller

Jul 25, 2014

(HealthDay)—A new formulation of a powerful narcotic painkiller that discourages potential abusers from snorting or injecting the drug has been approved by the U.S. Food and Drug Administration.

Race affects opioid selection for cancer pain

Jul 25, 2014

(HealthDay)—Racial disparities exist in the type of opioid prescribed for cancer pain, according to a study published online July 21 in the Journal of Clinical Oncology.

FDA approves tough-to-abuse formulation of oxycodone

Jul 25, 2014

(HealthDay)—Targiniq ER (oxycodone hydrochloride and naloxone hydrochloride extended release) has been approved by the U.S. Food and Drug Administration as a long-term, around-the-clock treatment for severe ...

Tough-to-abuse formulation of oxycodone approved

Jul 25, 2014

(HealthDay)—Targiniq ER (oxycodone hydrochloride and naloxone hydrochloride extended release) has been approved by the U.S. Food and Drug Administration as a long-term, around-the-clock treatment for severe pain when other ...

User comments