Potential diagnostic test for Alzheimer's would use cerebrospinal fluid

April 26, 2011

Researchers at the University of Kentucky are working on a potential diagnostic test for Alzheimer's disease, based on biomarkers in cerebrospinal fluid.

Scout Diagnostics, a company targeting early diagnosis of , recently received matching funds of $435,600 to support developing a laboratory test to detect and confirm Alzheimer's disease in its earliest stages. Scout was formed in 2006 by University of Kentucky chemistry professors and Sanders-Brown Center on Aging researchers Mark Lovell and Bert Lynn, along with CEO John Beran.

Lovell and Lynn have been working for some time with for Alzheimer's disease. They have identified specific markers for Alzheimer's in cerebrospinal fluid. The potential exists for researchers to develop a diagnostic test for early Alzheimer's using analysis of spinal fluid samples. This would be a significant development, as existing treatments for Alzheimer's disease are most effective if started extremely early in the progression of the disease — often before clinical signs of cognitive impairment are apparent.

The UK Sanders-Brown Center on Aging also maintains a large cohort of research volunteers, many of whom have donated cerebrospinal fluid for research on the .

"We were very pleased to hear of this award for the cutting-edge research that Dr. Lovell and his team at Scout Diagnostics are doing. A reliable biomarker for Alzheimer's disease is desperately needed to identify individuals very early in the disease process, so that therapeutic interventions can begin when they may be most effective, before memory problems develop," said Linda Van Eldik, director of the Sanders-Brown Center on Aging.

Related Stories

Recommended for you

Zika virus infection alters human and viral RNA

October 20, 2016

Researchers at University of California San Diego School of Medicine have discovered that Zika virus infection leads to modifications of both viral and human genetic material. These modifications—chemical tags known as ...

Food-poisoning bacteria may be behind Crohn's disease

October 19, 2016

People who retain a particular bacterium in their gut after a bout of food poisoning may be at an increased risk of developing Crohn's disease later in life, according to a new study led by researchers at McMaster University.

Neurodevelopmental model of Zika may provide rapid answers

October 19, 2016

A newly published study from researchers working in collaboration with the Regenerative Bioscience Center at the University of Georgia demonstrates fetal death and brain damage in early chick embryos similar to microcephaly—a ...

Scientists uncover new facets of Zika-related birth defects

October 17, 2016

In a study that could one day help eliminate the tragic birth defects caused by Zika virus, scientists from the Florida campus of The Scripps Research Institute (TSRI) have elucidated how the virus attacks the brains of newborns, ...


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.