Occupational lung diseases in Iraq and Afghanistan veterans
A Wednesday morning session will explore the inhalational exposures and respiratory outcomes of military deployment to Iraq and Afghanistan. Presenters will review current knowledge on complex inhalational exposures, epidemiologic studies, animal toxicology studies, and clinical lung findings in U.S. military men and women who are returning from Southwest Asia.
D6 "Occupational Lung Diseases in U.S. Military Personnel Deployed to Iraq and Afghanistan" will take place from 8:15 to 10:45 a.m. in the Wells Fargo Theatre Section 1 on the street level of the Colorado Convention Center.
The symposium will interest researchers and clinicians alike, said co-chair Cecile S. Rose, MD, MPH, who is professor at National Jewish Health and the University of Colorado in Denver.
"We've described a new disease called Iraq-Afghanistan War lung injury (IAW-LI), among soldiers deployed to these countries as part of Operation Iraqi Freedom, Operation Enduring Freedom, and Operation New Dawn" said Anthony Szema, MD, who will co-chair with Dr. Rose. "Not only do soldiers deployed to Iraq and Afghanistan suffer serious respiratory problems at a rate seven times that of soldiers deployed elsewhere, but the respiratory issues they present with show a unique pattern of fixed obstruction in half of cases, while most of the rest are clinically-reversible new-onset asthma, in addition to the rare interstitial lung disease called nonspecific interstitial pneumonitis associated with inhalation of titanium and iron."
Iraq and Afghanistan veterans are faced with a barrage of respiratory insults, including: 1) dust from the sand, 2) smoke from the burn pits, 3) aerosolized metals and chemicals from exploded IEDs, associated with 4) blast overpressure or shock waves to the lung, 5) outdoor aeroallergens such as date pollen, and 6) indoor aeroallergens such as mold aspergillus. Dr. Szema and colleagues have experimentally exposed mouse models to samples of the dust taken from Iraq and Afghanistan and found that it produces extreme histological responses, underscoring the severe exposures that these soldiers undergo.
Robert Miller, MD, of Vanderbilt University will discuss constrictive bronchiolitis in a cohort of soldiers deployed to Iraq.
Researchers face a number of issues, Dr. Rose said. For one, "there is a lack of pre-deployment lung function data, making it impossible to determine the extent of the damage that these exposures can cause," she said.
Further challenges include the spectrum of possible lung diseases that may be occurring from Southwest Asia exposures, such as asthma, constrictive bronchiolitis, acute eosinophilic pneumonia and rhinosinusitis, and the variability in exposures that may confer risk, including particulate matter from desert dusts, burn pits, vehicle exhaust and tobacco smoke.
Clinicians face a different set of challenges with this patient population, including "the role of targeted medical surveillance in determining need for further respiratory diagnostic evaluation, and, importantly, the role of surgical lung biopsy in clinical diagnosis of post-deployment lung disease," she said.
Provided by American Thoracic Society
- Reserve, National Guard at higher risk of alcohol-related problems after returning from combat Aug 12, 2008 | not rated yet | 0
- US soldiers with post-traumatic stress disorder more likely to feel long-term psychological effect Jan 03, 2011 | not rated yet | 0
- US soldiers in Iraq fighting drug-resistant bacteria after injuries May 16, 2007 | not rated yet | 0
- Wives of deployed soldiers suffer more depression, sleep disorders Jan 14, 2010 | not rated yet | 0
- Combat exposure may increase likelihood of newly reported high blood pressure Sep 14, 2009 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
Classical and Quantum Mechanics via Lie algebras
Apr 15, 2011 I'd like to open a discussion thread for version 2 of the draft of my book ''Classical and Quantum Mechanics via Lie algebras'', available online at http://lanl.arxiv.org/abs/0810.1019 , and for the...
- More from Physics Forums - Independent Research
More news stories
Chinese and U.S. scientists have used virus isolated from a person who died from H7N9 avian influenza infection to determine whether the virus could infect and be transmitted between ferrets. Ferrets are often used as a mammalian ...
Diseases, Conditions, Syndromes 48 minutes ago | not rated yet | 0 |
World Health Organization officials said Thursday that their probe into the deadly new coronavirus that has now claimed 22 lives is being delayed because of a dispute over the ownership rights to a sample—a claim disputed ...
Diseases, Conditions, Syndromes 3 hours ago | not rated yet | 0
A known difficulty in fighting influenza (flu) is the ability of the flu viruses to mutate and thus evade various medications that were previously found to be effective. Researchers at the Hebrew University of Jerusalem have ...
Diseases, Conditions, Syndromes 4 hours ago | not rated yet | 0 |
As the world prepares for what may be the next pandemic strain of influenza virus, in the H7N9 bird flu, a new UC Irvine study reveals that the 2009 H1N1 swine flu pandemic was deadliest for people under the age of 65, while ...
Diseases, Conditions, Syndromes 23 hours ago | not rated yet | 0
Ethnic background plays a surprisingly large role in how diabetes develops on a cellular level, according to two new studies led by researchers at the Stanford University School of Medicine.
2 minutes ago | not rated yet | 0 |
Cinnamon: Can the red-brown spice with the unmistakable fragrance and variety of uses offer an important benefit? The common baking spice might hold the key to delaying the onset of –– or warding off ...
24 minutes ago | not rated yet | 0 |
By discovering the new mechanism by which estrogen suppresses lipid synthesis in the liver, UC Irvine endocrinologists have revealed a potential new approach toward treating certain liver diseases.
25 minutes ago | not rated yet | 0 |
UCLA researchers examining outcomes for advanced heart-failure patients over the past two decades have found that, coinciding with the increased availability and use of new therapies, overall mortality has decreased and sudden ...
29 minutes ago | not rated yet | 0
Aortic arch pulse wave velocity, a measure of arterial stiffness, is a strong independent predictor of disease of the vessels that supply blood to the brain, according to a new study published in the June issue the journal ...
29 minutes ago | not rated yet | 0