Possible breakthrough in reducing the complications of the disease

(Medical Xpress) -- Newly published research from the Bruce Hammock lab at the University of California, Davis, and colleagues indicates a possible breakthrough in reducing the severity of complications associated with diabetes, including kidney, pain, inflammation and cardiac issues. The research, done with rodents, could lead to improved treatment of type 2 diabetes, a disease affecting nearly 30 million people in the United States alone.

"Inhibitors of the soluble epoxide hydrolase look very promising in animal models for reducing dramatically the severity of a number of problems associated with diabetes," said co-author Bruce Hammock, a distinguished professor of entomology at UC Davis and director of the UC Davis Superfund Research Program. "These benefits include a dramatic protection of , reduction in often debilitating as well as a reduction in blood pressure, vascular inflammation and ."

The genetic and , led by senior author Ayala Luria, now a researcher based in the Department of Urology at the UC Davis School of Medicine, is published today (May 12) in the (PNAS).

An estimated 25.8 million children and adults in the United States — 8.3 percent of the population — have diabetes; 7 million more are undiagnosed; and 79 million people are pre-diabetic, according to data from the 2011 National Diabetes Fact Sheet.

Luria, who continues to work in the Hammock lab, described as a complex disease in which a number of tissues are rendered "insulin resistant." Insulin action is mediated by a complex network of signaling events. "Epoxyeicosanoids or EETS are thought to be one of multiple classes of chemical mediators which influence insulin production and sensitivity," she said.

"Knowledge and data from this project," Luria said, "directly increases public awareness for the outcome of increasing insulin signaling, sensitivity and glucose homeostasis with the inhibition of soluble epoxide hydrolase and increasing endogenous levels of epoxy fatty acids in a model of diabetes type 2 induced by high fat diet."

"Using inhibitors of soluble epoxide hydrolase might produce therapeutically approach to reduce the burden and complications of insulin resistance and type 2," she said.

Luria joined the Hammock lab in 2004 to work on the molecular mechanism of soluble epoxide hydrolase in animal models. She previously held postdoctoral positions involving the structure of the plasma membrane and nuclear receptors during embryo development. She has a master's degree and doctorate in molecular biology and biochemistry from Bar Ilan University, Ramat Gan, Israel.

In the study, the 10-member research team investigated diet-inducted obesity and insulin resistance. They studied the role of the sEH gene in regulating glucose and the effects of sEH deletion and inhibition of body mass and obesity. The research involved the disruption of the Ephx2 gene; body weights, food intake and organ weights; metabolic measurements; immunohistochemistry.

"The research provides a perspective to what is emerging as a unifying theme in biological processes," said professor and chemist Bruce German of the Department of Food Science and Technology. "In various ways, higher organisms, including humans, use redundant signaling system strategies to manage their various complex processes. As a consequence, dysfunctions in one signaling system can lead to multiple problems (syndromes) while at the same time, pharmacologically active substances acting on a single target can nonetheless act beneficially on a wide range of health outcomes. Fatty acid epoxides appear to be one of these multi-functional signaling systems."

More information: www.pnas.org/content/early/201… 482108.full.pdf+html

Provided by University of California, Davis

not rated yet
add to favorites email to friend print save as pdf

Related Stories

Impaired fat-burning gene worsens diabetes

Feb 07, 2008

Researchers at the Swedish medical university Karolinska Institutet have in collaboration with researchers from Finland, China, Japan and the US discovered new cellular mechanisms that lead to in insulin resistance in people ...

Recommended for you

Recorded Ebola deaths top 7,000

6 hours ago

The worst Ebola outbreak on record has now killed more than 7,000 people, with many of the latest deaths reported in Sierra Leone, the World Health Organization said as United Nations Secretary-General Ban ...

Liberia holds Senate vote amid Ebola fears (Update)

11 hours ago

Health workers manned polling stations across Liberia on Saturday as voters cast their ballots in a twice-delayed Senate election that has been criticized for its potential to spread the deadly Ebola disease.

Evidence-based recs issued for systemic care in psoriasis

Dec 19, 2014

(HealthDay)—For appropriately selected patients with psoriasis, combining biologics with other systemic treatments, including phototherapy, oral medications, or other biologic, may result in greater efficacy ...

Bacteria in caramel apples kills at least four in US

Dec 19, 2014

A listeria outbreak believed to originate from commercially packaged caramel apples has killed at least four people in the United States and sickened 28 people since November, officials said Friday.

Steroid-based treatment may answer needs of pediatric EoE patients

Dec 19, 2014

A new formulation of oral budesonide suspension, a steroid-based treatment, is safe and effective in treating pediatric patients with eosinophilic esophagitis (EoE), according to a new study in Clinical Gastroenterology and Hepatology, the official clinical practice journal ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.