Threshold hemoglobin and mortality in people with stable coronary disease

June 1, 2011 in Cardiology

In this week's PLoS Medicine, Anoop Shah of University College London and colleagues report that, in people with stable coronary disease, there were threshold haemoglobin values below which mortality increased in a graded, continuous fashion. As well as a systematic review and statistical analysis of previous studies, the researchers conducted a retrospective analysis of patients from a prospective observational cohort.

Their findings suggest that there are thresholds of haemoglobin that are associated with increased risk of mortality in patients with angina or , and, though limited by the observational nature of its results, the study supports the rationale for conducting future randomised controlled trials to assess whether haemoglobin levels are causal and whether clinicians should intervene to increase haemoglobin levels, for example by oral iron supplementation.

The authors say that "Irrespective of a possible causal, reversible relationship between

haemoglobin concentration and mortality, further research is warranted to assess what incremental prognostic value haemoglobin might offer in risk stratifying patients with stable ."

More information: Shah AD, Nicholas O, Timmis AD, Feder G, Abrams KR, et al. (2011) Threshold Haemoglobin Levels and the Prognosis of Stable Coronary Disease: Two New Cohorts and a Systematic Review and Meta-Analysis. PLoS Med 8(5): e1000439. doi:10.1371/journal.pmed.1000439

Provided by Public Library of Science search and more info website

send feedback to editors
not rated yet  

Rank not rated yet
Tags

plos medicine, myocardial infarction, iron supplementation, coronary disease, retrospective analysis, controlled trial, statistical analysis, angina, mortality, patients
Related Stories
more news
Relevant PhysicsForums posts

More news stories

Registry confirms TAVI efficacy and safety in Asian patients

Transcatheter aortic valve implantation (TAVI) is effective and safe in Asian patients, according to early experience based on first results from a multicentre Asian registry reported at EuroPCR 2013.

Cardiology created 17 hours ago | popularity not rated yet | comments 0

Diagnostic coronary angiography: Functional flow reserve changes decisions in 25 percent of cases

Routinely measuring fractional flow reserve (FFR) using pressure wire assessment during coronary angiography for diagnosis of chest pain leads to significant changes in the management of one in four patients, according to ...

Cardiology created 20 hours ago | popularity not rated yet | comments 0

Feasibility trial reports deployment of new device for TAVI in aortic insufficiency

A new investigational device - the Helio System (TF-FA) - being developed for use with the Sapien XT Transcatheter Heart Valve was successfully deployed in all four patients in a small, first-in-human feasibility study of ...

Cardiology created 20 hours ago | popularity not rated yet | comments 0

Cardiac study used as source for new guidelines on treating people undergoing coronary artery bypass surgery

Cardiac research from the University of Alberta had serious impact as a source for the American College of Cardiology and the American Heart Association's new guidelines on how to treat patients undergoing coronary artery ...

Cardiology created 21 hours ago | popularity not rated yet | comments 0

Dual-source cardiac CT IDs CAD in hard-to-image patients

(HealthDay)—In patients who have previously been considered difficult to image, dual-source cardiac (DSC) computed tomography (CT) can identify clinically significant coronary artery disease, according ...

Cardiology created May 23, 2013 | popularity not rated yet | comments 0


Engineered cytomegalovirus protects monkeys from HIV equivalent

(Medical Xpress)—A new study by researchers in the US has shown that an ancient virus can be modified to help in the fight against the simian immunodeficiency virus SIV, which is the equivalent in monkeys ...

Researchers identify first drug targets in childhood genetic tumor disorder

Two mutations central to the development of infantile myofibromatosis (IM)—a disorder characterized by multiple tumors involving the skin, bone, and soft tissue—may provide new therapeutic targets, according to researchers ...

Hormone levels may provide key to understanding psychological disorders in women

Women at a particular stage in their monthly menstrual cycle may be more vulnerable to some of the psychological side-effects associated with stressful experiences, according to a study from UCL.

Going live: Immune cell activation in multiple sclerosis

Biological processes are generally based on events at the molecular and cellular level. To understand what happens in the course of infections, diseases or normal bodily functions, scientists would need to ...

Help at hand for people with schizophrenia

How can healthy people who hear voices help schizophrenics? Finding the answer for this is at the centre of research conducted at the University of Bergen.

Alzheimer's disease, the soft target of the euthanasia debate

(Medical Xpress)—The way Alzheimer's disease is portrayed by advocacy groups and the media is having undue influence on the euthanasia debate, according to a Deakin University nursing ethics professor.