New imaging technique captures brain activity in patients with chronic low back pain

July 27, 2011

Research from Brigham and Women's Hospital (BWH) uses a new imaging technique, arterial spin labeling, to show the areas of the brain that are activated when patients with low back pain have a worsening of their usual, chronic pain. This research is published in the August issue of the journal Anesthesiology.

"This study is a first step towards providing tools to objectively describe someone's chronic pain which is a subjective experience. We've found that when a patient has worsening of their usual pain, there are changes in the activity of the ," said Ajay Wasan, MD, MSc, lead author of the paper and a researcher in the Pain Management Center at BWH. "These changes occur in the network of areas in the brain that process pain and mood."

Researchers compared 16 patients with (CLBP) to 16 healthy subjects. Participants underwent three imaging sessions. The first was for a characterization and training session. During the second session, researchers used clinical , such as pelvic tilting or straight leg raising , to temporarily exacerbate back pain. In the third session, heat was applied to the skin at an intensity that matched the pain levels during the second session. Patients rated their pain levels before and after the sessions and after each stimulation during the sessions.

During the last two sessions, researchers used the arterial spin labeling technique, which allows them to quantify the blood flow to specific regions of the brain over time. The amount of is indicative of in that region of the brain. They found that there was increased activity in the brain of CLBP patients only when they experienced a worsening of their chronic pain and not during the heat pain session or in the healthy participants. Researchers also note that some of the areas of the brain that were activated when participants experienced a worsening of have been shown to be associated with other types of pain found in other studies. However, researchers also observed activation of some areas, including the superior parietal lobule, which have been less frequently associated with pain in previous research.

"While this study begins to uncover some of the basic physiology of the brain as it processes pain, more studies are needed to help us understand how the brain function may change over the course of treatment of pain and to examine the brain mechanisms by which pain improves," Wasan said. "We are getting closer to describing, on an objective level, how the body and brain are reacting when a patient reports having more . We are hopeful that this could lead to an understanding of an individual patient's neurocircuitry and that knowledge could lead to therapies that would be tailored to the individual."

Explore further: Treatment of chronic low back pain can reverse abnormal brain activity and function

Related Stories

Recommended for you

New theory explains how beta waves arise in the brain

July 25, 2016

Beta rhythms, or waves of brain activity with an approximately 20 Hz frequency, accompany vital fundamental behaviors such as attention, sensation and motion and are associated with some disorders such as Parkinson's disease. ...

Visual pigment rhodopsin forms two-molecule complexes in vivo

July 25, 2016

The study of rhodopsin—the molecule that allows the eye to detect dim light—has a long and well-recognized history of more than 100 years. Nevertheless, there is still controversy about the structure in which the molecule ...

Scientists show how memories are linked in the brain

July 22, 2016

Some memories just seem to go together. Think about an important experience in your life. You may also closely remember another experience that happened around that time too, like exchanging vows at your wedding, and then ...

Novel compounds arrested epilepsy development in mice

July 22, 2016

A team led by Nicolas Bazan, MD, PhD, Boyd Professor and Director of LSU Health New Orleans' Neuroscience Center of Excellence, has developed neuroprotective compounds that may prevent the development of epilepsy. The findings ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.