PXR: A stepping stone from environmental chemical to cancer?

Several chemicals that can accumulate to high levels in our body (for example BPA and some pesticides) have been recently linked to an increased risk of cancer and/or impaired responsiveness to anticancer drugs. A team of researchers, led by Sridhar Mani, at Albert Einstein College of Medicine, New York, has now identified a potential mechanistic link between environmental exposure to these foreign chemicals (xenogens) and cancer drug therapy response and survival.

PXR is one protein by which cells (including tumor cells) can sense xenogens. In their study, Mani and colleagues determined that activation of PXR was sufficient to enhance the cancerous characteristics of human cell lines and primary human colon xenografted into immune system–deficient mice. Further analysis indicated FXR activation leads to colon cancer growth through the induction of the growth factor FGF19. The authors therefore suggest that it will be important to investigate further the extent to which the environment might play a role in tumor recurrence through PXR activation.

More information: View this article at: www.jci.org/articles/view/4151… d5f620785644dd3ba8e6

Provided by Journal of Clinical Investigation

5 /5 (1 vote)
add to favorites email to friend print save as pdf

Related Stories

Inflammation directly linked to colon cancer

Feb 02, 2009

While chronic inflammation is widely believed to be a predisposing factor for colon cancer, the exact mechanisms linking these conditions have remained elusive. Scientists at the Melbourne Branch of the international Ludwig ...

New biomarkers for predicting the spread of colon cancer

Jan 13, 2010

Scientists in China are reporting discovery of two proteins present in the blood, of people with colon cancer that may serve as the potential biomarkers for accurately predicting whether the disease will spread. ...

Understanding the anticancer effects of vitamin D3

Jul 06, 2009

The active form of vitamin D3 seems to have anticancer effects. To try and understand the mechanisms underlying these effects, researchers previously set out to identify genes whose expression in a human colon cancer cell ...

Recommended for you

Same cancer, different time zone

14 hours ago

Just as no two people possess the same genetic makeup, a recent study has shown that no two single tumor cells in breast cancer patients have an identical genome.

User comments