Fat around the heart boosts heart-attack risk

Recently, interest in the fat around the heart -so called pericardial fat- is rapidly growing. Even a thin person can have pericardial fat. Several studies suggest that pericardial fat induces inflammation of the artery wall by secretion of pro-inflammatory proteins and plays a role in the pathogenesis of coronary artery disease. However, there is no information regarding the impact of pericardial fat on coronary arterial remodeling and plaque vulnerability- related with acute coronary syndrome.

"The aim of our study was to evaluate the relationship between pericardial fat and intravascular ultrasound (IVUS) findings, mainly coronary remodeling, in patients with ," said Dr Ogura.

One hundred and eight consecutive patients with de novo lesions located in native coronary artery were studied. The pericardial fat thickness on the right ventricle was measured using transthoracic echocardiography, and arterial remodeling of culprit lesion was assessed by pre-interventional IVUS. The remodeling index (RI) was calculated as lesion divided by the reference external elastic membrane cross-sectional area, Positive remodeling (PR) was defined as RI>1.05, intermediate remodeling (IR) as between 0.95 and 1.05, and negative remodeling (NR) as <0.95. IVUS findings included plaque eccentricity and morphology-lipid rich, fibrous and calcified.

There was a significant relationship between pericardial fat thickness and RI(r= 0.36, p=0.0001). Patients with a higher pericardial fat thickness (>10mm, n=55) were significantly associated with high (25.2±3.6kg/m² vs. 23.9±2.8 kg/m², p=0.04), high plasma triglyceride level (189.1±103.8mg/dl vs. 146.1±80.9 mg/dl, p=0.02) ,and high plasma urinary acid level(6.8±1.5mg/dl vs. 5.9±1.5 mg/dl, p=0.02). PR and noncalcified plaque were more common in patients with a higher pericardial thickness (PR ;43.6% vs. 18.9%,p=0.02. non-calcified plaque; 89.1% vs.66.0%, p=0.004).

There was no significant relationship between pericardial fat thickness and plaque eccentricity. Multivariate analysis showed that high pericardial fat thickness was an independent factor affecting coronary positive remodeling (odds ratio (OR):3.05,p=0.02).

In conclusion, pericardial fat thickness was significantly correlated with the coronary arterial remodeling and non calcified plaque - related with .

add to favorites email to friend print save as pdf

Related Stories

Fat around the heart may increase risk of heart attacks

Jul 30, 2008

When it comes to risk for a heart attack, having excess fat around the heart may be worse than having a high body mass index or a thick waist, according to researchers from Wake Forest University Baptist Medical Center and ...

Drug may reduce coronary artery plaque

Oct 12, 2008

Research presented at the 20th annual Transcatheter Cardiovascular Therapeutics (TCT) scientific symposium, sponsored by the Cardiovascular Research Foundation (CRF), suggests that olmesartan, a drug commonly used to treat ...

Imaging fat layer around heart can help predict disease

Mar 15, 2010

Imaging epicardial adipose tissue, or the layer of fat around the heart, can provide extra information compared with standard diagnostic techniques such as coronary artery calcium scoring, according to research by cardiologists ...

Recommended for you

Study: Removing clot helps limit stroke disability

Dec 17, 2014

For the first time in several decades, a new treatment has been shown to limit the damage from a common type of stroke. Researchers in the Netherlands found that mechanically removing a clot in addition to using a clot-busting ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.