Metabolomics as a basis for gender-specific drugs

Analyses of the metabolic profile of blood serum have revealed significant differences in metabolites between men and women. In a study to be published on August 11 in the open-access journal PLoS Genetics, scientists at the Helmholtz Zentrum München have concluded that there is a need for gender-specific therapies.

Gender-specific therapies may be required for some diseases as there are significant differences between male and female metabolism. Such differences were shown to exist for 101 of the 131 metabolites – above all in lipid and amino acid species – in the sera of more than 3,000 volunteers who took part in the population-based KORA study. Professor Thomas Illig and Dr. Kirstin Mittelstrass see this as proof that "in terms of molecular profiles, men and women have to be assigned to two completely different categories. That means that we also need gender-specific approaches to the treatment of diseases."

The researchers combined genetic data with metabolic profiles, which indicate the metabolic paths that are active given the specific conditions. The combination of genetics and metabolomics provides insight into the causes and progression of specific diseases. This could allow new therapeutic approaches and drugs to be developed, and enable markers to be found for the early recognition of diseases such as diabetes.

In the next phase, the scientists will increase the number of and evaluate further studies from a gender-specific point of view. "Through the combination of gender-specific evaluation, genetic association studies and metabolomics we will gain a detailed understanding of how major widespread diseases such as diabetes mellitus develop," Professor Illig says.

More information: Mittelstrass K, Ried JS, Yu Z, Krumsiek J, Gieger C, et al. (2011) Discovery of Sexual Dimorphisms in Metabolic and Genetic Biomarkers. PLoS Genet 7(8): e1002215. doi:10.1371/journal.pgen.1002215

add to favorites email to friend print save as pdf

Related Stories

Gender affects reaction to HIV-prevention materials

Jun 10, 2008

Various intervention strategies have been implemented to curb the rise of HIV, and a factor that might affect exposure to interventionsis gender. A new study in the Journal of Applied Social Psychology reviewed the behavi ...

Genetic link to gender identity

Oct 30, 2008

In the largest ever genetic study of male to female transsexuals Australian researchers have found a significant genetic link between gender identity and a gene involved in testosterone action.

Recommended for you

Mutation disables innate immune system

16 hours ago

A Ludwig Maximilian University of Munich team has shown that defects in the JAGN1 gene inhibit the function of a specific type of white blood cells, and account for a rare congenital immune deficiency that ...

Study identifies genetic change in autism-related gene

Aug 28, 2014

A new study from Bradley Hospital has identified a genetic change in a recently identified autism-associated gene, which may provide further insight into the causes of autism. The study, now published online in the Journal of ...

NIH issues finalized policy on genomic data sharing

Aug 27, 2014

The National Institutes of Health has issued a final NIH Genomic Data Sharing (GDS) policy to promote data sharing as a way to speed the translation of data into knowledge, products and procedures that improve health while ...

The genes behind the guardians of the airways

Aug 27, 2014

Dysfunctions in cilia, tiny hair-like structures that protrude from the surface of cells, are responsible for a number of human diseases. However the genes involved in making cilia have remained largely elusive. ...

User comments