A 3-D reconstructed image of neural dendritic trees using the advanced electron microscope technology

Neurons in the brain play a role as an electric wire conveying an electrical signal. Because this electric wire is connected with various joints (synapse), various brain functions can occur. A neuron which has dendritic trees on it, receives the signals with many synapses located on those dendritic trees, and carries out functions by combining the received signals.

The research team of Associate Professor Kubota from The National Institute for Physiological Sciences, revealed the minute properties of dendritic trees by reconstructing 3D images using the advanced electron microscope technology. The research team proved the principle that "neurons normalize receiving signals, making it easier to receive farther signals because of the morphological characteristics of dendritic trees". It is reported in Scientific Reports, an offshoot of English science magazine Nature (September 13, 2011 electronic edition).

The team focused on the four distinct neurons in the cerebral cortex of the brain (non- pyramidal neurons). A neuron receives signals from other neurons through neurites called dendritic trees. They succeeded in reconstruction of minute morphology of dendritic trees on the computer using the advanced electron microscope technology. Consistent with this observation, they have been able to prove other standing principles underlying the morphology of dendritic trees. The size and distance of the dendritic tree and signal determine the clarity and strength of reception. A larger dendritic tree can receive father signals more effectively.

Associate Professor Kubota says, "This advanced technology of 3D using the electron microscope can be used for other neurons. For instance, if we can find out how the minute morphology of dendritic trees changes because of various brain such as schizophrenia, autism, depression, and senile dementia, it will contribute to work out the pathological condition of those diseases. "

Provided by National Institute for Physiological Sciences

5 /5 (3 votes)
add to favorites email to friend print save as pdf

Related Stories

Neurons found to be similar to Electoral College

Sep 14, 2009

A tiny neuron is a very complicated structure. Its complex network of dendrites, axons and synapses is constantly dealing with information, deciding whether or not to send a nerve impulse, to drive a certain action.

First evidence of native dendritic cells in brain

May 15, 2008

In a finding that has the potential to change the way researchers think about the brain, scientists at Rockefeller University have found dendritic cells where they’ve never been seen before: among this organ’s ...

Molecular 'foreman' discovered for brain wiring

Nov 21, 2007

Researchers have identified a master regulatory molecule that is responsible for triggering the remodeling of neuronal connections that is critical for learning. Malfunctioning of the connection-remodeling machinery that ...

Recommended for you

User comments