Missing genes may separate coach potato from active cousin

You may think your lack of resolve to get off the couch to exercise is because you're lazy, but McMaster University researchers have discovered it may be you are missing key genes.

The researchers made their unexpected finding while working with healthy, specially-bred mice, some of which had two genes in muscle essential for removed. The genes control the protein AMP-activated protein kinase (AMPK), an enzyme that is switched on when you exercise.

"Mice love to run," said Gregory Steinberg, associate professor of medicine in the Michael G. DeGroote School of Medicine and Canada Research Chair in Metabolism and Obesity.

"While the normal mice could run for miles, those without the genes in their muscle could only run the same distance as down the hall and back. It was remarkable. The mice looked identical to their brothers or sisters but within seconds we knew which ones had the genes and which one didn't."

The researchers found the without the muscle AMPK genes had lower levels of and an impaired ability for their muscles to take up glucose while they exercise.

"When you exercise you get more mitochondria growing in your muscle. If you don't exercise, the number of mitochondria goes down. By removing these we identified the key regulator of the mitochondria is the enzyme AMPK," said Steinberg.

Thousands of scientists around the world are working on AMPK but the McMaster team is the first to demonstrate its essential role in exercise. Their research appears in the current issue of the .

Steinberg said the findings are important for individuals who find it difficult to exercise, such as the obese, asthmatics and people in wheelchairs. Their inability to exercise may lead to other complications such as diabetes and .

The study, he thinks, has a message for couch potatoes. "As we remove activity from our lives due to emerging technology, the base level of fitness in the population is going down and that is reducing the mitochondria in people's muscles. This in turn makes it so much harder for people to start exercising."

Steinberg himself runs or bikes to work. "It is the only way that I can manage to make sure I stay fit."

Related Stories

Power-boosting signal in muscle declines with age

Feb 06, 2007

As people age, they may have to exercise even harder to get the benefits afforded to younger folk. That's the suggestion of a report in the February issue of the journal Cell Metabolism, published by Cell Press, showing that a ...

Regular exercise can delay the aging process

Feb 22, 2011

(PhysOrg.com) -- A team of Canadian scientists working with mice genetically modified to age twice as fast as normal has found regular exercise keeps them young.

Well-known enzyme is unexpected contributor to brain growth

Mar 12, 2009

An enzyme researchers have studied for years because of its potential connections to cancer, diabetes, heart disease, hypertension and stroke, appears to have yet another major role to play: helping create and maintain the ...

Apelin hormone injections powerfully lower blood sugar

Nov 04, 2008

By injecting a hormone produced by fat and other tissues into mice, researchers report in the November Cell Metabolism that they significantly lowered blood sugar levels in normal and obese mice. The findings suggest that t ...

Recommended for you

Study clarifies parents as source of new disease mutations

Jul 31, 2014

Scientists have long speculated that mosaicism – a biological phenomenon, in which cells within the same person have a different genetic makeup – plays a bigger role in the transmission of rare disease mutations than ...

How black truffles deal with the jumpers in their genome

Jul 31, 2014

The black truffle uses reversible epigenetic processes to regulate its genes, and adapt to changes in its surroundings. The 'methylome' - a picture of the genome regulation taking place in the truffle, is published in the ...

Gene research targets scarring process

Jul 28, 2014

Scientists have identified three genes that may be the key to preventing scar formation after burn injury, and even healing existing scars.

User comments

Adjust slider to filter visible comments by rank

Display comments: newest first

Squirrel
1 / 5 (2) Sep 05, 2011
All athletes should be handicapped by in regard to genetic factors determining AMPK so that athletic competition is fair.

What is the point of banning performance enhancing drugs while legally allowing performance enhancing genes to determining who gets to stand on podiums and win medals?
ubavontuba
5 / 5 (1) Sep 05, 2011
"Coach" potato?

"Excuse me, please, but Mr. Potato Head has requested an upgrade to First Class."

Spellcheck might assist with, but it isn't a replacement for proofreading.
Sinister1811
not rated yet Sep 05, 2011
"Coach" potato? LOL