New method could help prevent osteoarthritis
A new method is set to help doctors diagnose osteoarthritis at such an early stage that it will be possible to delay the progression of the disease by many years, or maybe even stop it entirely.
The joint disease osteoarthritis is one of our most common chronic diseases and one of the primary causes of disability for people around the world.
"Osteoarthritis often attacks the knee and hip joints and breaks down the impact absorbing cartilage found there. For those affected, the progression of the disease usually takes many years, with gradually increasing pain which often leads to disability", says Carl Siversson, who has just defended his thesis in Medical Radiation Physics at Lund University in Sweden.
One of the problems with osteoarthritis has been diagnosing and monitoring the disease before symptoms become evident. It has therefore been difficult to change or delay the course of the disease. A few years ago, researchers from Lund University and Harvard Medical School developed a method to measure the degree of osteoarthritis using an MRI scanner, even at a very early stage. The method is called dGEMRIC (delayed gadolinium-enhanced MRI of cartilage).
"This was major progress, but one problem was that the measurements could only be performed in a limited part of the cartilage. We have now improved the method so that we can study all the cartilage in the joint at once. We have achieved this by solving the problem of how to correct all the irregularities in the MRI images", says Carl Siversson.
The improved method has now been tested both on healthy individuals and on individuals with osteoarthritis, and the results show that the disease can now be monitored in ways that were not previously possible, according to Carl Siversson.
"Now we are continuing our work to make the method easy for doctors to use in their practice. Our hope is that the method will also be significant for future drug development", says Carl Siversson, who after completing his PhD will continue his research at Harvard Medical School in Boston, USA.
More information: The new method is described in Carl Siversson's thesis Three-dimensional T1 quantification techniques for assessment of cartilage quality using dGEMRIC: www.lunduniversity… stid=2064122
Provided by Lund University
- New test to diagnose osteoarthritis early Aug 20, 2008 | not rated yet | 0
- Out of joint Sep 19, 2008 | not rated yet | 0
- Sodium MRI gives new insights into detecting osteoarthritis, researchers find Aug 27, 2010 | not rated yet | 0
- MRI techniques can detect early osteoarthritis Aug 15, 2011 | not rated yet | 0
- Obesity contributes to rapid cartilage loss Jul 14, 2009 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
Assumptions of Griffith's fracture theory
2 hours ago Any experts on Griffith's fracture theory? I am studying the subject and I am having hard time finding out if the theory is valid for all possible...
Current leading voltage or vice versa concept
3 hours ago Hello, I was wondering if there is a conceptual explanation for when current leads voltage or vice versa for capacitors or inductors with AC...
Angular Frequency of AC voltage
7 hours ago Hello, I am wondering, what is the physical interpretation of the angular frequency of AC voltage? I don't see the physicality of what the angle...
Modeling Rigid Body - Unsure about Euler angles and angular velocity
7 hours ago I'm modeling a single 3D rigid body in preparation for some more complicated modeling in order to gain a better understanding of Euler angles, the...
Function for a bullet's path
8 hours ago I've been mulling this over all weekend, and I've decided to get some help on this. The problem is writing a function to describe a bullet's path....
Elementary questions relating to Newton's laws of motion
10 hours ago i) If a wall breaks when it gets hit by a cannonball, did the wall exert an equal and opposite force on the cannonball? ii) Would the force...
- More from Physics Forums - Classical Physics
More news stories
A novel study reports that white men and women of European descent inherit common foot disorders, such as bunions (hallux valgus) and lesser toe deformities, including hammer or claw toe. Findings from the Framingham Foot ...
Arthritis & Rheumatism May 20, 2013 | not rated yet | 0 |
Scientists at Johns Hopkins have turned their view of osteoarthritis (OA) inside out. Literally. Instead of seeing the painful degenerative disease as a problem primarily of the cartilage that cushions joints, ...
Arthritis & Rheumatism May 19, 2013 | 4.8 / 5 (6) | 0 |
(HealthDay)—Compared to clinical diagnosis of synovitis, ultrasound-detected synovitis provides either improved sensitivity or specificity when used with the American College of Rheumatology/European League ...
Arthritis & Rheumatism May 15, 2013 | not rated yet | 0
(HealthDay)—A genome-wide linkage scan has identified the chromosome 17p11.2-q11.2 region as the susceptibility locus for fibromyalgia, according to research published in the April issue of Arthritis & ...
Arthritis & Rheumatism May 11, 2013 | not rated yet | 0
Scientists have discovered that fat cells in the knee secrete a protein linked to arthritis, a finding that paves the way for new gene therapies that could offer relief and mobility to millions worldwide.
Arthritis & Rheumatism May 08, 2013 | 5 / 5 (5) | 0 |
Johns Hopkins researchers say they have discovered specific chemical alterations in two genes that, when present during pregnancy, reliably predict whether a woman will develop postpartum depression.
14 minutes ago | not rated yet | 0 |
Children who have suffered maltreatment are 36% more likely to be obese in adulthood compared to non-maltreated children, according to a new study by King's College London. The authors estimate that the prevention or effective ...
14 minutes ago | not rated yet | 0
(Medical Xpress)—A research team, led by Jeremy Barr, a biology post-doctoral fellow, unveils a new immune system that protects humans and animals from infection.
9 hours ago | 4.6 / 5 (12) | 4 |
Early-life exposure to traffic-related air pollution was significantly associated with higher hyperactivity scores at age 7, according to new research from the University of Cincinnati (UC) and Cincinnati Children's Hospital ...
4 hours ago | not rated yet | 0 |
New research suggests that a compound abundant in the Mediterranean diet takes away cancer cells' "superpower" to escape death. By altering a very specific step in gene regulation, this compound essentially re-educates cancer ...
12 hours ago | 4.8 / 5 (11) | 2 |
Salamanders' immune systems are key to their remarkable ability to regrow limbs, and could also underpin their ability to regenerate spinal cords, brain tissue and even parts of their hearts, scientists have ...
13 hours ago | 4.8 / 5 (6) | 2 |