Finding pathways to cancer progression may lead to identification of targeted therapies
Researchers are working to discover how genes interact with each other to lead to cancer progression. This research is expected to lead the way toward the discovery of new targeted therapies against breast cancer, according to a study presented at the Second AACR International Conference on Frontiers in Basic Cancer Research, held here Sept. 14-18, 2011.
For example, the researchers found that a diuretic used to treat hypertension and edema also stops breast cancer cells from progressing, although this potential treatment is a long way from human trials, said lead researcher Bin Zhang, Ph.D., principal scientist and group leader at Sage Bionetworks in Seattle, Wash.
The researchers analyzed multiple large-scale cancer genomic data sets to find novel pathways and driver genes that help breast cancer progress. They then tested them in the laboratory against various compounds and drugs to see how they would react, explained Zhang.
"We tried to objectively derive a global picture of how genes interact with each other to impact cancer progression so that we could understand holistically the mechanisms underlying this complex disease. Then, we can systematically identify optimal intervention points for drug development," he said.
The researchers found that many genes function as groups corresponding to different pathways, so future targeted therapies would work better if they target more than one pathway. This also gives credence to the idea that using combination therapy against the different genetic pathways might help fight cancer better.
Although they tested breast cancer cells, Zhang said, their methods could be used to test other cancers and even other diseases.
"There is an enormous amount of cancer characterization data available, yet it remains challenging to establish models that predict tumor progression and drug response. We developed complex and advanced algorithms to reconstruct multiscale gene regulatory networks that reveal global patterns of gene interactions in cancer and also detail regulatory maps," he said. "These networks will serve as a blueprint for us to understand cancer progression and develop novel therapeutics."
Zhang and colleagues have found a diuretic used to treat hypertension and edema affected the progression of cancer cells. They predicted and successfully validated its novel effectiveness in preferentially killing cancer cells through inhibiting cell cycle pathways that are responsible for uncontrolled cell proliferation.
Based on their prediction, they believe this drug is as effective in culture as several marketed cancer drugs. However, there is still some time until it can be tested in people, according to Zhang.
Provided by American Association for Cancer Research
- Herceptin targets breast cancer stem cells Jul 09, 2008 | not rated yet | 0
- Scientists show protein accelerates breast cancer progression in animal models Jun 20, 2007 | not rated yet | 0
- Discovery of epigenetic memory during breast cancer Jan 25, 2010 | not rated yet | 0
- New technique to study the genetics of breast cancer Nov 11, 2008 | not rated yet | 0
- Genes identified which predict response to breast cancer treatment Sep 24, 2007 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
How can there be villous adenoma in colon, if there are no villi there
2 hours ago As title suggest. Thanks :smile:
How can there be a term called "intestinal metaplasia" of stomach
May 21, 2013 Hello everyone, Ok Stomach's normal epithelium is simple columnar, now in intestinal type of adenocarcinoma of stomach it undergoes "intestinal...
Pressure-volume curve: Elastic Recoil Pressure don't make sense
May 18, 2013 From pressure-volume curve of the lung and chest wall (attached photo), I don't understand why would the elastic recoil pressure of the lung is...
If you became brain-dead, would you want them to pull the plug?
May 17, 2013 I'd want the rest of me to stay alive. Sure it's a lousy way to live but it beats being all-the-way dead. Maybe if I make it 20 years they'll...
MRI bill question
May 15, 2013 Dear PFers, The hospital gave us a $12k bill for one MRI (head with contrast). The people I talked to at the hospital tell me that they do not...
Ratio of Hydrogen of Oxygen in Dessicated Animal Protein
May 13, 2013 As an experiment, for the past few months I've been consuming at least one portion of Jell-O or unflavored Knox gelatin per day. I'm 64, in very...
- More from Physics Forums - Medical Sciences
More news stories
Study leader, Professor John Mathews from the University of Melbourne said this small increase in cancer risk must be weighed against the undoubted benefits from CT scans in diagnosing and monitoring disease.
Cancer 17 minutes ago | not rated yet | 0
Cancer survivors are no more likely to stop smoking, cut down on alcohol, or exercise more often than the general population, according to new research published in the British Journal of Cancer today (Wednesday)
Cancer 1 hour ago | not rated yet | 0
Beta-blockers, normally used for high blood pressure, could enhance the effectiveness of chemotherapies in treating neuroblastoma, a type of children's cancer, according to a new study published in the British Jo ...
Cancer 2 hours ago | not rated yet | 0
A Japanese cancer specialist said Wednesday she has started the world's first clinical trial of a powerful, non-surgical, short-term radiation therapy for breast cancer.
Cancer 2 hours ago | not rated yet | 0
The gap between life expectancy in patients with a mental illness and the general population has widened since 1985 and efforts to reduce this gap should focus on improving physical health, suggest researchers in a paper ...
Cancer 15 hours ago | not rated yet | 0
(Medical Xpress)—A report published today shows a 2.6% decrease in the amount of alcohol sold per adult in Scotland in the year following the introduction of the Alcohol etc. (Scotland) Act in October 2011.
1 hour ago | not rated yet | 0
(Medical Xpress)—High blood pressure is something that has traditionally been a problem in Scotland, but might there be a link to our climate?
50 minutes ago | not rated yet | 0
(Medical Xpress)—Health care spending is much higher for older Americans than for younger adults and children, on average, and analysts have said that increasing spending leads to longer life expectancy.
40 minutes ago | not rated yet | 0
The DESolve bioresorbable coronary scaffold system achieves good efficacy and safety with low rates of late lumen loss and major coronary adverse events at six months, show first results from the pivotal DESolve Nx trial ...
22 minutes ago | not rated yet | 0
More than 40 percent of patients being treated for COPD at a federally funded clinic did not have the disease, researchers found after evaluating the patients with spirometry, the diagnostic "gold standard" for chronic obstructive ...
20 minutes ago | not rated yet | 0
Results from a large observational study reported at EuroPCR 2013 today question whether bivalirudin is superior to heparin in the absence of GPIIb/IIIa blockade, showing similar 30-day mortality in patients with non-ST segment ...
20 minutes ago | not rated yet | 0