Stents may reduce heart attacks by delivering downstream medication
Researchers at Cleveland Clinic have discovered that cardiac patients receiving medicated stents -- a procedure that occurs often when blood vessels are blocked -- have a lower likelihood of suffering heart attacks or developing new blockages in the vessel downstream from the stent.
Stents have been used to prevent re-narrowing of coronary arteries after balloon angioplasty and newer designs have included coatings with medications to prevent re-narrowing from occurring within the stent after implantation. The recent study led by Richard Krasuski, M.D., Director of Adult Congenital Heart Disease Services and a staff cardiologist in the Section of Clinical Cardiology in the Department of Cardiovascular Medicine at the Miller Family Heart & Vascular Institute at Cleveland Clinic -- suggests that these medicated stents may deliver the medication to the vessel beyond the stent.
In a study recently published in the American Heart Journal, Dr. Krasuski and his colleagues demonstrate that patients receiving medicated stents have a lower likelihood of suffering heart attacks or developing new blockages in the vessel downstream from the stent.
"Though there have been concerns about clots forming inside drug-releasing stents, the totality of data suggests that patients receiving drug-coated stents do better than patients receiving bare metal stents," Dr. Krasuski said. "It has not been clear before, however, why preventing re-blockage in the location of a stent would have such a large benefit, but our study suggests that there may be more that the stent is doing. When blood flows through the stent, medication not only reaches the vessel it is touching but likely the distal vessel as well. In this way it could be having a much more profound effect on the vessel."
If this concept is confirmed it could revolutionize treatment of cardiovascular disease and problems with other organ systems as well. Stents could be altered to deliver many different medications in small amounts directly to the blood vessels. This could maximize the benefits of different drugs and reduce their toxic effects as well as improve patient compliance.
Provided by Cleveland Clinic
- Drug-coated stents less risky for heart bypass patients Jan 22, 2009 | not rated yet | 0
- Drug-releasing stent shows promise for improving outcomes in patients with coronary artery disease Apr 22, 2008 | not rated yet | 0
- Drug-eluting stents yield better outcomes than bare-metal ones Nov 19, 2007 | not rated yet | 0
- Boston Scientific admits stent risks Sep 07, 2006 | not rated yet | 0
- Non-cardiac surgery too soon after stenting raises risk of heart problems May 04, 2010 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
Pressure-volume curve: Elastic Recoil Pressure don't make sense
May 18, 2013 From pressure-volume curve of the lung and chest wall (attached photo), I don't understand why would the elastic recoil pressure of the lung is...
If you became brain-dead, would you want them to pull the plug?
May 17, 2013 I'd want the rest of me to stay alive. Sure it's a lousy way to live but it beats being all-the-way dead. Maybe if I make it 20 years they'll...
MRI bill question
May 15, 2013 Dear PFers, The hospital gave us a $12k bill for one MRI (head with contrast). The people I talked to at the hospital tell me that they do not...
Ratio of Hydrogen of Oxygen in Dessicated Animal Protein
May 13, 2013 As an experiment, for the past few months I've been consuming at least one portion of Jell-O or unflavored Knox gelatin per day. I'm 64, in very...
Alcohol and acetaminophen
May 13, 2013 Edit: sorry for the typo in the title , can't edit I looked around on google quite a bit and it's very hard to find precise information on the...
Marie Curie's leukemia
May 13, 2013 Does anyone know what might be the cause of Marie Curie's cancer
- More from Physics Forums - Medical Sciences
More news stories
In their quest to learn more about the variability of cells between and within tissues, biomedical scientists have devised tools capable of simultaneously measuring dozens of characteristics of individual ...
Medical research 7 hours ago | 5 / 5 (1) | 0 |
In 2008 researchers from the University of Southern Denmark showed that the drug thioridazine, which has previously been used to treat schizophrenia, is also a powerful weapon against antibiotic-resistant bacteria such as ...
Medical research May 17, 2013 | 3.7 / 5 (3) | 0 |
Scientists investigating the interaction of a group of proteins in the brain responsible for protecting nerve cells from damage have identified a new target that could increase cell survival.
Medical research May 17, 2013 | 5 / 5 (1) | 0
New findings by researchers carrying out experiments at the U.S. Department of Energy Office of Science's Advanced Photon Source (APS) help explain why some drugs that interact with two kinds of human serotonin ...
Medical research May 17, 2013 | 4 / 5 (1) | 0 |
Researchers at the University of Wisconsin have identified a potential new risk factor for obstructive sleep apnea: asthma. Using data from the National Institutes of Health (Heart, Lung, and Blood Institute)-funded Wisconsin ...
6 hours ago | not rated yet | 0 |
A new study looking at sleep-disordered breathing (SDB) and markers for Alzheimer's disease (AD) risk in cerebrospinal fluid (CSF) and neuroimaging adds to the growing body of research linking the two.
6 hours ago | 5 / 5 (1) | 0 |
Scientists at Johns Hopkins have turned their view of osteoarthritis (OA) inside out. Literally. Instead of seeing the painful degenerative disease as a problem primarily of the cartilage that cushions joints, ...
7 hours ago | 5 / 5 (2) | 0 |
Gourmands and foodies everywhere have long recognized ginger as a great way to add a little peppery zing to both sweet and savory dishes; now, a study from researchers at Columbia University shows purified components of the ...
6 hours ago | not rated yet | 0
The hunt for an HIV vaccine has gobbled up $8 billion in the past decade, and the failure of the most recent efficacy trial has delivered yet another setback to 26 years of efforts.
11 hours ago | not rated yet | 0
The devastating effect of Alzheimer's disease on bilingual people has been thrown into focus in Canada, where the sudden loss of a second language can leave sufferers feeling like strangers in their own country.
9 hours ago | not rated yet | 0