Bacteria enter via mucus-making gut cells
October 3, 2011 in Diseases, Conditions, SyndromesCells making slippery mucus provide a sticking point for disease-causing bacteria in the gut, according to a study published on October 3 in the Journal of Experimental Medicine.
A foodborne bacterium called Listeria monocytogenes (sometimes found in stinky cheeses) invades the body by binding to a protein called E-cadherin. However, as E-cadherin is normally buried within the junctions between gut cells, and is thus hidden from the cell surface, it's not clear how the bug gains traction.
In response to Listeria invasion, specialized gut cells called goblet cells produce mucus in an attempt to flush the bacteria away. Scientists in France now find that the reorganization required for goblet cells to expel their slippery product also exposes E-cadherin on their surface, allowing Listeria to grab hold and cause systemic infection.
More information: Nikitas, G., et al. 2011. J. Exp. Med. doi:10.1084/jem.20110560
Provided by
Rockefeller University
-
Stanford investigators decipher how dangerous food-borne pathogen evades body's defenses
May 13, 2010 |
not rated yet |
0
-
Radiation-killed bacteria vaccine created
Jul 25, 2006 |
not rated yet |
0
-
Listeria clever at finding its way into bloodstream, causing sickness
Oct 25, 2010 |
not rated yet |
0
-
Food poisoning bacteria prefer duck to beef on meat factory surfaces
Sep 10, 2008 |
not rated yet |
0
-
A sticky solution for identifying effective probiotics
Nov 24, 2009 |
not rated yet |
0
-
Of mice and mental models: Neuroscientific implications of risk-optimized behavior in the mouse
23 hours ago |
not rated yet |
0
-
Limits to growth: Scientists identify key metastasis-enabling enzyme
May 22, 2012 |
5 / 5 (4) |
0
-
Seeing is as seeing does: Spatially-structured retinal input in early development of cortical maps
Apr 26, 2012 |
5 / 5 (4) |
1
-
Dreamless nights: Brain activity during nonrapid eye movement sleep
Apr 09, 2012 |
4.4 / 5 (12) |
0
-
Take your time: Neurobiology sheds light on the superiority of spaced vs. massed learning
Mar 28, 2012 |
4.5 / 5 (21) |
3
-
Classical and Quantum Mechanics via Lie algebras
Apr 15, 2011
- More from Physics Forums - Independent Research
More news stories
Flesh-Eating bacteria no cause for panic, experts say
(HealthDay) -- Despite scary headlines by the score, most people don't have to fear that they'll be the next victim of the so-called flesh-eating bacteria disease, experts say.
Diseases, Conditions, Syndromes
17 hours ago |
not rated yet |
0
World Health Assembly endorses new plan to increase global access to vaccines
Ministers of Health from 194 countries at the Sixty-fifth World Health Assembly today endorsed a landmark Global Vaccine Action Plan (GVAP), a roadmap to prevent millions of deaths by 2020 through more equitable access to ...
Diseases, Conditions, Syndromes
20 hours ago |
not rated yet |
0
Physicians definitively links irritable bowel syndrome and bacteria in gut
An overgrowth of bacteria in the gut has been definitively linked to Irritable Bowel Syndrome in the results of a new Cedars-Sinai study which used cultures from the small intestine. This is the first study to use this "gold ...
Diseases, Conditions, Syndromes
21 hours ago |
not rated yet |
0
|
Study provides compelling evidence for an effective new treatment for tinnitus
According to new research, a multidisciplinary approach to treating tinnitus that combines cognitive behaviour therapy with sound-based tinnitus retraining therapy is significantly more effective than currently available ...
Diseases, Conditions, Syndromes
May 24, 2012 |
not rated yet |
0
Infections may be deadly for many dialysis patients
An infection called peritonitis commonly arises in the weeks before many dialysis patients die, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN). The findings sugges ...
Diseases, Conditions, Syndromes
May 24, 2012 |
not rated yet |
0
Of mice and mental models: Neuroscientific implications of risk-optimized behavior in the mouse
(Medical Xpress) -- Regardless of an organism’s biological complexity, every encephalized animal continuously makes under-informed behavioral choices that can have serious consequences. Despite its ubiquity, ...
Cancer may require simpler genetic mutations than previously thought
Chromosomal deletions in DNA often involve just one of two gene copies inherited from either parent. But scientists haven't known how a deletion in one gene from one parent, called a "hemizygous" deletion, can contribute ...
Inherited DNA change explains overactive leukemia gene
A small inherited change in DNA is largely responsible for overactivating a gene linked to poor treatment response in people with acute leukemia.
Tongue analysis software uses ancient Chinese medicine to warn of disease
For 5,000 years, the Chinese have used a system of medicine based on the flow and balance of positive and negative energies in the body. In this system, the appearance of the tongue is one of the measures used to classify ...
Skp2 activates cancer-promoting, glucose-processing Akt
HER2 and its epidermal growth factor receptor cousins mobilize a specialized protein to activate a major player in cancer development and sugar metabolism, scientists report in the May 25 issue of Cell.
Early physical therapist treatment associated with reduced risk of healthcare utilization and reduced overall healthcare
A new study published in Spine shows that early treatment by a physical therapist for low back pain (LBP), as compared to delayed treatment, was associated with reduced risk of subsequent healthcare utilization and lower ...
