Possible link between autism and airway abnormality

October 24, 2011

Autism and autistic spectrum disorders (ASD) are currently diagnosed primarily through subjective observation of autistic behaviors. However, new research, presented at CHEST 2011, the 77th annual meeting of the American College of Chest Physicians (ACCP), suggests that a physical abnormality in the airway may be a prominent indicator for autism and autistic spectrum disorders, making it a possible diagnostic marker for this disease.

"With all of the bronchoscopies I've performed, I have not seen this type of abnormality in children who aren't autistic," said study author Barbara Stewart, MD, Nemours Children's Clinic, Pensacola, Florida. "It appears to be a definitive marker for or autistic spectrum disorder."

Dr. Stewart evaluated 49 children (< 18 years) with autism or ASD who were seen in a pulmonary clinic with a diagnosis of cough that was unresponsive to therapy. Bronchoscopic evaluations revealed that all patients with autism had anatomy that was initially normal, followed by take-offs in the lower airway that were doubled, or "doublets," as they are referred to by the author. Dr. Stewart further observed that, to her knowledge, no patient without autism has ever manifested doublet anomalies.

"Another way to think of this is "symmetric doubling" of airways in the lower airways. When airways divide beyond the first generation, they typically branch like a tree, with one branch on one side and one on the other. A "doublet" occurs when there are twin branches that come off together instead of one, which are exactly symmetrical, in each of the lower locations that can be seen."

Patients who have "doublets" in the lower airways may have higher airway resistance, which, as Dr. Stewart explained, "might be why the population of children with autistic spectrum disorder are not truly athletic people."

Although bronchoscopy can help identify the structure of the airway, Dr. Stewart cautions that it is not yet ready to be a screening or for autism.

"Bronchoscopy is a useful tool, but it is still an invasive surgical procedure and one that should not be undertaken lightly. The practitioner should consider the root cause for this embryologic anomaly, asking the deeper question concerning the genetic link of the doubling," said Dr. Stewart. "However, if there is a medical reason to perform bronchoscopic evaluation of the airway, one should obtain the maximum amount of information during that procedure."

"The potential association between autism and airway structure is intriguing; however, additional studies are needed to determine the genetic factors which may then lead to airway abnormalities," said David Gutterman, MD, FCCP, President of the .

Related Stories

New research may lead to improved diagnosis of autism

May 31, 2011

Functional magnetic resonance imaging (fMRI) may provide an early and objective indicator of autism, according to researchers at Columbia University in New York City, who used the technique to document language impairment ...

Recommended for you

Experimental MERS vaccine shows promise in animal studies

July 28, 2015

A two-step regimen of experimental vaccines against Middle East respiratory syndrome (MERS) prompted immune responses in mice and rhesus macaques, report National Institutes of Health scientists who designed the vaccines. ...

Can social isolation fuel epidemics?

July 21, 2015

Conventional wisdom has it that the more people stay within their own social groups and avoid others, the less likely it is small disease outbreaks turn into full-blown epidemics. But the conventional wisdom is wrong, according ...

Lack of knowledge on animal disease leaves humans at risk

July 20, 2015

Researchers from the University of Sydney have painted the most detailed picture to date of major infectious diseases shared between wildlife and livestock, and found a huge gap in knowledge about diseases which could spread ...

IBD genetically similar in Europeans and non-Europeans

July 20, 2015

The first genetic study of inflammatory bowel disease (IBD) to include individuals from diverse populations has shown that the regions of the genome underlying the disease are consistent around the world. This study, conducted ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.