Possible link between autism and airway abnormality

"With all of the bronchoscopies I've performed, I have not seen this type of abnormality in children who aren't autistic," said study author Barbara Stewart, MD, Nemours Children's Clinic, Pensacola, Florida. "It appears to be a definitive marker for autism or autistic spectrum disorder."

Dr. Stewart evaluated 49 children (< 18 years) with autism or ASD who were seen in a pulmonary clinic with a diagnosis of cough that was unresponsive to therapy. Bronchoscopic evaluations revealed that all patients with autism had anatomy that was initially normal, followed by take-offs in the lower airway that were doubled, or "doublets," as they are referred to by the author. Dr. Stewart further observed that, to her knowledge, no patient without autism has ever manifested doublet anomalies.

"Another way to think of this is "symmetric doubling" of airways in the lower airways. When airways divide beyond the first generation, they typically branch like a tree, with one branch on one side and one on the other. A "doublet" occurs when there are twin branches that come off together instead of one, which are exactly symmetrical, in each of the lower locations that can be seen."

Patients who have "doublets" in the lower airways may have higher airway resistance, which, as Dr. Stewart explained, "might be why the population of children with autistic spectrum disorder are not truly athletic people."

Although bronchoscopy can help identify the structure of the airway, Dr. Stewart cautions that it is not yet ready to be a screening or diagnostic tool for autism.

"Bronchoscopy is a useful tool, but it is still an invasive surgical procedure and one that should not be undertaken lightly. The practitioner should consider the root cause for this embryologic anomaly, asking the deeper question concerning the genetic link of the doubling," said Dr. Stewart. "However, if there is a medical reason to perform bronchoscopic evaluation of the airway, one should obtain the maximum amount of information during that procedure."

"The potential association between autism and airway structure is intriguing; however, additional studies are needed to determine the genetic factors which may then lead to airway abnormalities," said David Gutterman, MD, FCCP, President of the American College of Chest Physicians.

Provided by American College of Chest Physicians