Study identifies specific bacteria which precede autoimmune diabetes

A study led by Matej Oresic from VTT Technical Research Centre of Finland suggests that autoimmune diabetes is preceded by diminished gut microbial diversity of the Clostridium leptum subgroup, elevated plasma leptin and enhanced glucose-stimulated insulin secretion.

In collaboration with the DIPP - Finnish and Prediction study, VTT researches have previously found that specific precede early β-cell autoimmunity markers in children who subsequently progress to type 1 . However, the question remained what are the environmental causes and tissue-specific mechanisms leading to these disturbances?

Matej Orešič from VTT Technical Research Centre of Finland and collaborators Eriika Savontaus from the University of Turku, Samuel Kaski from Aalto University and Mikael Knip from the University of Helsinki set out to address this question, and the results were published on October 27, 2011 in PLoS Computational Biology journal.

The team carried out a study using non-obese diabetic (NOD) mice that recapitulated the protocol used in the DIPP clinical study, followed up by independent studies in which NOD mice were studied in relation to the risk of diabetes progression. Researchers found that young female NOD mice that later progress to autoimmune diabetes exhibit the same metabolic pattern as prediabetic children. These metabolic changes are accompanied by enhanced glucose-stimulated , upregulation of insulinotropic amino acids in islets, elevated plasma leptin and adiponectin, and diminished gut of the leptum subgroup.

The elucidation of early metabolic pathways associated with progression to Type 1 diabetes points to novel avenues for early disease prevention. The ongoing efforts of VTT researchers are focused on the potential of specific bacteria from the C. leptum subgroup to help prevent Type 1 diabetes.

This study was supported by the Finnish Funding Agency for Technology and Innovation Tekes, the Seventh Framework Program of the European Community, and Juvenile Diabetes Research Foundation.

The environmental factors and molecular mechanisms leading to Type 1 diabetes are poorly understood and of great public health interest. The incidence of inflammatory and autoimmune diseases is rising faster than for any other major disease, and these diseases are affecting a wide spectrum of the population. The number of new cases of Type 1 diabetes in European children less than 5 years of age is expected to double between 2005 and 2020.

More information: M. Sysi-Aho, A. Ermolov, P. V. Gopalacharyulu, A. Tripathi, T. Seppänen-Laakso, J. Maukonen, I. Mattila, S. T. Ruohonen, L. Vähätalo, L. Yetukuri, T. Härkönen, E. Lindfors, J. Nikkilä, J. Ilonen, O. Simell, M. Saarela, M. Knip, S. Kaski, E. Savontaus, M. Orešič,
Metabolic regulation in progression to autoimmune diabetes, PLoS Comp. Biol. 7 (10), e1002257 (2011). www.ploscompbiol.org/article/i… journal.pcbi.1002257

Provided by VTT Technical Research Centre of Finland

5 /5 (1 vote)
add to favorites email to friend print save as pdf

Related Stories

New scientific knowledge on juvenile diabetes

Dec 17, 2008

Finnish scientists have reported a breakthrough in the attempts to understand the development of type 1 diabetes. They discovered disturbances in lipid and amino acid metabolism in children who later progressed to type 1 ...

Type 1 diabetes triggered by 'lazy' regulatory T-cells

Jan 14, 2008

A research team led by Dr. Ciriaco A. Piccirillo of McGill University’s Department of Microbiology and Immunology has discovered that in some individuals, the specialized immunoregulatory T-cells that regulate the body’s ...

Recommended for you

Evidence-based recs issued for systemic care in psoriasis

19 hours ago

(HealthDay)—For appropriately selected patients with psoriasis, combining biologics with other systemic treatments, including phototherapy, oral medications, or other biologic, may result in greater efficacy ...

Bacteria in caramel apples kills at least four in US

20 hours ago

A listeria outbreak believed to originate from commercially packaged caramel apples has killed at least four people in the United States and sickened 28 people since November, officials said Friday.

Steroid-based treatment may answer needs of pediatric EoE patients

20 hours ago

A new formulation of oral budesonide suspension, a steroid-based treatment, is safe and effective in treating pediatric patients with eosinophilic esophagitis (EoE), according to a new study in Clinical Gastroenterology and Hepatology, the official clinical practice journal ...

Discovery of genes that predispose a severe form of COPD

22 hours ago

A study by Ramcés Falfán-Valencia, researcher at the National Institute of Respiratory Diseases (INER), found that the mestizo Mexican population has a number of variations in certain genes that predispose ...

On the environmental trail of food pathogens

Dec 19, 2014

Tracking one of the deadliest food contamination organisms through produce farms and natural environments alike, Cornell microbiologists are showing how to use big datasets to predict where the next outbreak could start.

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.