Vitamin B derivative helps diabetics with mild kidney disease

A vitamin B6 derivative may help slow or prevent the progression of mild kidney disease in patients with diabetes, according to a study appearing in an upcoming issue of the Journal of the American Society Nephrology (JASN). The drug may benefit increasing numbers of patients as the prevalence of diabetes rises.

Approximately 40% of all patients who need dialysis or a can blame diabetes for their kidney problems. Because the number of patients with is expected to double by 2030, the prevalence of kidney failure is sure to increase. New therapies that can delay the progression of may help prevent and save lives. Researchers have wondered whether the drug Pyridorin, a derivative of vitamin B6, may be such a candidate. Pyridorin targets several cellular processes that may be relevant to the progression of diabetic kidney disease.

Edmund Lewis, MD (Rush University Medical Center) and his colleagues within the Collaborative Study Group (a large clinical trial group comprised of various kidney care centers) tested the potential of Pyridorin (generic name pyridoxamine dihydrochloride) for treating patients with diabetic kidney disease.

For one year during the double-blind, randomized, placebo-controlled trial, 317 patients received placebo twice a day, Pyridorin at a dose of 150 mg twice a day, or Pyridorin at a dose of 300 mg twice a day.

Overall, the drug did not provide any benefit over placebo for slowing or preventing the progression of diabetic kidney disease; however, Pyridorin did help patients with only mild forms of the disease.

"It appears the drug may be beneficial in a sub-group of patients with only mild kidney disease but does not appear to be beneficial for patients with more advanced kidney disease," said Dr. Lewis. "The results warrant further trials in patients with mild diabetic kidney disease," he added.

More information: The article, entitled "A Randomized Trial of Pyridorin in Type 2 Diabetes," will appear online on Thursday, October 27, 2011, doi:10.1681/ASN.2011030272

add to favorites email to friend print save as pdf

Related Stories

Promising kidney drug fails in large clinical trial

Oct 27, 2011

What was hoped to be a promising new drug to protect the kidneys has failed to benefit diabetes patients with kidney disease, according to a study appearing in an upcoming issue of the Journal of the American Society Nephrology (JASN) ...

'Silent strokes' linked to kidney failure in diabetics

Jan 28, 2010

In patients with type 2 diabetes, silent cerebral infarction (SCI) -- small areas of brain damage caused by injury to small blood vessels -- signals an increased risk of progressive kidney disease and kidney failure, according ...

Recommended for you

App for headache sufferers shows success

11 hours ago

A unique app that helps headache sufferers to record the severity and regularity of their pain is being used as part of a Griffith research study.

West African airline suspends flights amid Ebola (Update)

17 hours ago

(AP)—Police officers deployed to Liberia's international airport to ensure passengers are screened for Ebola symptoms as a major regional airline announced Tuesday it was suspending flights to the cities hardest hit by ...

User comments