Women with polycystic ovary syndrome at increased risk of pregnancy complications
Women with polycystic ovary syndrome are more likely to have problems with pregnancy regardless of whether they are undergoing fertility treatment, claims new research published in the British Medical Journal today.
The Swedish researchers call for better monitoring of women with polycystic ovary syndrome during pregnancy and childbirth because they are more prone to premature birth, diabetes and pre-eclampsia outcomes which are not explained by assisted reproductive technology, as previously thought.
Polycystic ovary syndrome is a common disorder that affects between 5% and 15% of women of reproductive age.
Women with the condition typically have small cysts around the edge of their ovaries. Symptoms include irregular periods, problems with ovulation, weight gain and excessive hair growth. Women with the condition are more likely to have fertility treatment.
Researchers from the Karolinska Institutet and Karolinska University Hospital in Stockholm, Sweden set out to study the risk of adverse pregnancy outcomes in women with the condition, taking into account maternal characteristics and fertility treatment.
They studied nationwide data on 3,787 births among women with polycystic ovary syndrome and 1,191,336 births among women without the condition.
They measured risk of adverse pregnancy outcomes, such as diabetes brought on by pregnancy, pre-eclampsia, premature birth, stillbirth, neonatal death, and poor health of newborns, taking into account maternal characteristics (body mass index and age), socioeconomic factors, and fertility treatment such as IVF.
Analysis of the results showed that women diagnosed with polycystic ovary syndrome were more often obese and more commonly used assisted reproductive technology than women without the condition.
There was a strong link between polycystic ovary syndrome and pre-eclampsia women with the syndrome were 45% more likely to experience pre-eclampsia and were also more than twice as likely to give birth prematurely and/or to develop diabetes while pregnant.
Babies born to mothers with polycystic ovary syndrome were more prone to be large for gestational age and tended to develop asphyxia during labour.
Overall, the researchers found that a diagnosis of polycystic ovary syndrome was associated with increased risks of adverse pregnancy outcomes that could not be attributed to the increased use of assisted reproductive technology or maternal characteristics such as advanced age or being overweight or obese.
The researchers conclude: "These women may need increased surveillance during pregnancy and childbirth. Future research would benefit from focusing on glucose control, medical treatment and hormonal status among women with polycystic ovary syndrome during pregnancy."
In an accompanying editorial, Professor Nick Macklon from the University of Southampton, says: "It is clear that women with polycystic ovary syndrome should be considered "high risk" obstetric patients and that midwives, general practitioners, and obstetricians should monitor these women as such."
However, he believes that "more evidence is required to support the use of currently used interventions designed to reduce perinatal risk, and this requires a greater understanding of the different polycystic ovary syndrome phenotypes and the underlying mechanisms by which this common condition alters pregnancy outcomes."
Provided by British Medical Journal
- Obesity gene associated with susceptibility to polycystic ovary syndrome Mar 17, 2009 | not rated yet | 0
- Women with PCOS have family heart disease link Oct 05, 2011 | not rated yet | 0
- Acupuncture may bring relief for a common condition in women Aug 20, 2009 | not rated yet | 0
- Miscarriage and infertility treatment increase pre-eclampsia risk Dec 18, 2008 | not rated yet | 0
- Fat behaves differently in patients with polycistic ovary syndrome Feb 02, 2010 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
2 hours ago Alright, so in Pathfinder (like Dungeons and Dragons) there's a spell that allows you to lift/move stuff within 25 ft with 5 pounds of force. A...
5 hours ago So energy can only be converted... So when you squeeze the bulb on a blood pressure cuff, you are applying kinetic energy. Then the cuff fills with...
How does momentum, inertia and drag affect the motion of an object?
7 hours ago How does momentum and inertia affect changes in speed, when considering acceleration from thrust, or from decelleration from drag? Say, for a...
What is Time-Varying Voltage?
8 hours ago In circuits, we have no problem saying that the voltage difference between two point is [itex]\cos(\omega t)[/itex], but what does that actually...
Contextual Relationships Between Momentum, Energy, and Force.
10 hours ago *I apologize in advance for the length of this post, if you wish to reduce reading skip to paragraph 5. Or if you are super lazy, the final...
Barometric pressure and the math behind it. Very interesting, I think.
11 hours ago Hey guys, I was actually researching the life of Edmond Halley and discovered that he discovered the relationship between barometric pressure and the...
- More from Physics Forums - Classical Physics
More news stories
New research indicates that women's reproductive function may be tied to their immune status. Previous studies have found this association in human males, but not females.
Obstetrics & gynaecology 16 hours ago | not rated yet | 0 |
Elsevier today announced the publication of a recent study in Reproductive BioMedicine Online on 5-day old human blastocysts showing that those with an abnormal chromosomal composition can be identified by the rate at whic ...
Obstetrics & gynaecology May 16, 2013 | not rated yet | 0
While global attention has for decades been focused on reducing maternal mortality, population-based data on other causes of death among women of reproductive age has been virtually non-existent. A study conducted by researchers ...
Obstetrics & gynaecology May 14, 2013 | not rated yet | 0
Doctors have terminated the pregnancy of a 23-year-old Turkish woman who was the first ever to receive a uterus transplant from a dead donor, a hospital in southern Turkey said on Tuesday.
Obstetrics & gynaecology May 14, 2013 | not rated yet | 0
Big names in medicine are set to give an upbeat assessment of the war on AIDS on Tuesday, 30 years after French researchers identified the virus that causes the disease.
3 hours ago | not rated yet | 0
For combat veterans suffering from post-traumatic stress disorder, 'fear circuitry' in the brain never rests
Chronic trauma can inflict lasting damage to brain regions associated with fear and anxiety. Previous imaging studies of people with post-traumatic stress disorder, or PTSD, have shown that these brain regions can over-or ...
4 hours ago | not rated yet | 0 |
(Medical Xpress)—What if the quality of your work depends more on your focus on the piano keys or canvas or laptop than your musical or painting or computing skills? If target users can be convinced, they ...
16 hours ago | 3.7 / 5 (3) | 0 |
The neural machinery underlying our olfactory sense continues to be an enigma for neuroscience. A recent review in Neuron seeks to expand traditional ideas about how neurons in the olfactory bulb might encode information about ...
15 hours ago | not rated yet | 0 |
In 2008 researchers from the University of Southern Denmark showed that the drug thioridazine, which has previously been used to treat schizophrenia, is also a powerful weapon against antibiotic-resistant bacteria such as ...
13 hours ago | 3.7 / 5 (3) | 0 |
In order to avoid harms associated with alcohol consumption, in 2009 the National Institute on Alcohol Abuse and Alcoholism issued guidelines that define low-risk drinking. These guidelines differ for men and women: no more ...
13 hours ago | not rated yet | 0 |