Blood pressure research addresses differences
(Medical Xpress) -- A UT Arlington researcher’s recent work may hold clues as to why hypertension is more severe and strikes earlier in the African-American population.
David Keller, an assistant professor of kinesiology and associate director of UT Arlington’s Center for Health Living and Longevity, has found differences in the way that African Americans and Caucasians respond to simulated hypertension. When tested, African-American men in his study showed a blunted ability to reflexively adjust their heart rates in response to short-term hypertension
Keller is studying arterial baroreflex function in African Americans at rest and during exercise as part of a project funded by the National Institutes of Health National Heart, Lung and Blood Institute. Results of the first phase of his work were recently published in the American Journal of Physiology: Heart and Circulatory Physiology, in an article called “Carotid baroreflex responsiveness is impaired in normotensive African American men.”
More than 40 percent of non-Hispanic blacks have high blood pressure, also known as hypertension, according to the American Heart Association. The rate of hypertension in the general population is one in three. The condition can lead to heart disease or stroke. Additionally, African Americans are at nearly double the risk of fatal stroke related to hypertension and are more than four times more likely to develop end-stage renal disease associated with hypertension than Caucasians.
“While some lifestyle factors are known predictors, there remains much that we must understand about the way in which the disease develops and factors that contribute to its development,” said Carolyn Cason, interim vice president for research at UT Arlington. “Research like that being done by Dr. Keller is key to establishing the scientific foundation upon which new, successful treatments can be built."
Co-authors on the study were former UT Arlington graduate students Seth Holwerda and Diana Fulton, as well as Wendy Eubank-Holden, currently a postdoctoral research associate at UT Health Science Center in Fort Worth.
"The Center for Healthy Living and Longevity is very focused on addressing serious health issues that affect the community here in North Texas and across the U.S.," said Lou Fincher, chairwoman of the kinesiology department at UT Arlington. "David Keller's research allows students to participate in work that could one day help everyone know more about their risks for developing hypertension."
The arterial baroreflex is the primary short-term regulator of arterial blood pressure. The baroreflex receptors, or “sensors” are located in the large blood vessels in the neck and the aorta. The reflex works with the brain to monitor blood pressure levels and increase or decrease blood supply based on the needs of the body.
Keller and his co-authors selected 30 men, ages 18 to 33, for their study, half of who were Caucasian and half of who were African American. None of the study participants had a history of either hypertension (high blood pressure) or hypotension (low blood pressure). During the experiments, researchers simulated both conditions with pressure or suction applied to the participants’ necks for short periods of time.
The team monitored the participants’ heart rates and mean arterial pressure, which is the pressure across the walls of their arteries.
“At rest ability to control blood pressure was not markedly different, but the ability to reflexively control the heart rate was different, especially in simulated hypertension,” Keller said. “This seems to reflect something inherently different about short term blood pressure regulation. We believe those differences may persist and could be involved in the long term regulation and could help to explain the increased incidence of hypertension in African Americans.”
Keller would like to explore what role the vagus nerve, which regulates heart rate, plays in these racial differences. Next, he plans to study participants’ responses to the same experiments while they are exercising.
Keller was recently asked to participate in an American Journal of Physiology podcast about his work. It is available here: ajpheart.podbean.c… merican-men/ .
Journal reference: American Journal of Physiology
Provided by University of Texas at Arlington
- Study examines ethnic differences in sleep quality and blood pressure Oct 29, 2007 | not rated yet | 0
- Hypertension develops early, silently, in African-American men Nov 17, 2008 | not rated yet | 0
- Differences in cell response could explain higher rates of hypertension in African-Americans Aug 29, 2011 | not rated yet | 0
- Dangerous blood pressure increases during exercise can be blocked: research Apr 04, 2011 | not rated yet | 0
- Up to half of hypertension patients are not reaching blood pressure goals Dec 11, 2007 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
Classical and Quantum Mechanics via Lie algebras
Apr 15, 2011 I'd like to open a discussion thread for version 2 of the draft of my book ''Classical and Quantum Mechanics via Lie algebras'', available online at http://lanl.arxiv.org/abs/0810.1019 , and for the...
- More from Physics Forums - Independent Research
More news stories
Talking on a hands-free device while behind the wheel can lead to a sharp increase in errors that could imperil other drivers on the road, according to new research from the University of Alberta.
Health 4 hours ago | not rated yet | 0
(HealthDay)—More than one in four of those eligible for new premium assistance tax credits under the Affordable Care Act (ACA) do not have a checking account and will not be able to receive premiums from ...
Health 6 hours ago | not rated yet | 0
After studying noise in one French Quarter neighborhood of New Orleans to determine whether or not noise levels exceeded municipal ordinances, Annette Hurley, PhD, Assistant Professor of Audiology at LSU Health Sciences Center ...
Health 7 hours ago | not rated yet | 0
Young children who missed more than half of recommended well-child visits had up to twice the risk of hospitalization compared to children who attended most of their visits, according to a study published today in the American Jo ...
Health 7 hours ago | not rated yet | 0
The individualisation of drug treatments to support patients to self-manage their conditions is a concept that sits at the heart of policy, but a recent study in BMJ Open shows that there is no concrete defini ...
Health 10 hours ago | 3 / 5 (1) | 0
Two mutations central to the development of infantile myofibromatosis (IM)—a disorder characterized by multiple tumors involving the skin, bone, and soft tissue—may provide new therapeutic targets, according to researchers ...
4 hours ago | 5 / 5 (1) | 0 |
(Medical Xpress)—A new study by researchers in the US has shown that an ancient virus can be modified to help in the fight against the simian immunodeficiency virus SIV, which is the equivalent in monkeys ...
10 hours ago | 5 / 5 (3) | 0 |
Women at a particular stage in their monthly menstrual cycle may be more vulnerable to some of the psychological side-effects associated with stressful experiences, according to a study from UCL.
7 hours ago | 5 / 5 (1) | 0 |
Biological processes are generally based on events at the molecular and cellular level. To understand what happens in the course of infections, diseases or normal bodily functions, scientists would need to ...
7 hours ago | 5 / 5 (2) | 0 |
Kate O'Reilly's spring allergy survival kit includes the usual stuff - nasal sprays, allergy pills and a box of tissues. This season, she's added a new weapon to her line of defense: an app on her smartphone.
5 hours ago | not rated yet | 0