Researchers closer to the super bug puzzle
Infectious diseases specialists from Austin Health are working closely with Microbiologists from the University of Melbourne to understand how Staph is becoming resistant to all antibiotic therapies.
The treatment of serious infections caused by Staphylococcus aureus (Golden Staph) is complicated by the development of antibiotic resistance. Seriously ill patients, vulnerable to infections can be at additional risk if antimicrobial agents become less effective in fighting infections.
Published today in the journal PLoS Pathogens, a new piece has been added to the puzzle, making the picture clearer. By using whole genome DNA sequencing of strains obtained from patients during persistent blood stream infections, Dr Timothy Stinear and Associate Professor Ben Howden, senior research fellows from the Department of Microbiology and Immunology have discovered how Staph can make one small change to its DNA and then develop resistance to the last-line antibiotic, vancomycin.
"We have applied the latest genome sequencing technology to show that Staph can readily become vancomycin (antibiotic) resistant by acquiring a single mutation in its DNA. When the bacteria mutate, they are reprogramming themselves, changing their cell walls to resist the action of our antibiotics" said Dr Stinear.
Associate Professor Howden, who is also the head of Microbiology at Austin Health, is concerned by the implications of this discovery for patients. "Worryingly, this mutation also makes Staph more resistant to another last-line antibiotic, daptomycin, even though this drug had never been used for treatment. These last-line therapies are more toxic and cause additional side-effects in already compromised patients." Associate Professor Howden said.
"This study highlights the high adaptability of Staph in the face of antimicrobial treatment and suggests we need to improve the way in which we use antibiotics to treat serious bacterial infections." he said.
Provided by University of Melbourne
- Research provides insight into new drug resistance in hospital microbes Jul 13, 2011 | not rated yet | 0
- Nationwide study finds US meat and poultry is widely contaminated Apr 15, 2011 | not rated yet | 0
- Staph infections carry long-term risks Jul 03, 2008 | not rated yet | 0
- Study of staph shows how bacteria evolve resistance Jun 04, 2007 | not rated yet | 0
- Six staph cases reported in North Carolina Oct 19, 2007 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
Classical and Quantum Mechanics via Lie algebras
Apr 15, 2011 I'd like to open a discussion thread for version 2 of the draft of my book ''Classical and Quantum Mechanics via Lie algebras'', available online at http://lanl.arxiv.org/abs/0810.1019 , and for the...
- More from Physics Forums - Independent Research
More news stories
A new approach for immunizing against influenza elicited a more potent immune response and broader protection than the currently licensed seasonal influenza vaccines when tested in mice and ferrets. The vaccine ...
Diseases, Conditions, Syndromes 8 minutes ago | not rated yet | 0 |
Patients with underlying heart failure are more likely to experience adverse outcomes from mild hypothyroidism, according to a recent study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & ...
Diseases, Conditions, Syndromes 1 hour ago | not rated yet | 0
University of Granada scientists have patented a new treatment for acne that is based on completely natural substances and is much more effective than artificial formulas because it does not create resistance ...
Diseases, Conditions, Syndromes 3 hours ago | not rated yet | 0
More than 40 percent of patients being treated for COPD at a federally funded clinic did not have the disease, researchers found after evaluating the patients with spirometry, the diagnostic "gold standard" for chronic obstructive ...
Diseases, Conditions, Syndromes 6 hours ago | not rated yet | 0
What effect does a father's depression have on his young son or daughter? When fathers report a high level of emotional intimacy in their marriage, their children benefit, said a University of Illinois study.
13 minutes ago | not rated yet | 0
Johns Hopkins researchers report that hospitals may be reaping enormous income for patients whose hospital stays are complicated by preventable bloodstream infections contracted in their intensive care units.
10 minutes ago | not rated yet | 0
A University of Illinois researcher says that the cornerstone of our efforts to alleviate food insecurity should be to encourage more people to participate in the Supplemental Nutrition Assistance Program (SNAP) "because ...
12 minutes ago | not rated yet | 0
A 2012 survey of internal medicine residents at Massachusetts General Hospital (MGH) – one of the nation's leading teaching hospitals – found that more than half rated the training they had received in addiction and other ...
11 minutes ago | not rated yet | 0
A new study from researchers in Japan indicates that obstructive sleep apnea (OSA) is independently associated with visceral (abdominal) fat accumulation only in men, perhaps explaining gender differences in the impact of ...
10 minutes ago | not rated yet | 0
Researchers from Queen Mary, University of London have led the largest sequencing study of human disease to date, investigating the genetic basis of six autoimmune diseases.
2 hours ago | not rated yet | 0 |