Group develops method of killing cancer cells with antibodies and light
(Medical Xpress) -- Traditionally, there are three major ways to combat cancer in people: surgical removal, radiation therapy and chemotherapy. And while all three have been proven to be effective in treating some types of cancer, all three also have unpleasant side effects. Its for this reason that researchers continue to try to find other ways to kill cancer cells. Now, in a paper published in Nature Medicine, a team from the National Cancer Institute in the United States, says that it has developed a type of photoimmunotherapy that combines a light-sensitive dye that has a special chemical in it and antibodies to target and kill cancer cells when light is shined on them.
Photoimmunotherapy has been tried before, but not in this way, in previous research such antibodies were not nearly so target specific, meaning they tended to kill other cells as well. In this latest research, the team was able to use tumor specific antibodies that would attach themselves to the cancer cells, but would remain dormant. It was only when the same cancer cells were also exposed to a chemical called IR700 and then exposed to light that the antibodies went to work killing the cancer cells.
In their lab studies, the team inserted a type of skin cancer into the skin on the back of a mouse; when given the drug and then exposed to light, the research team found that the size of the tumor in the mouse was significantly reduced compared to control mice. They also found that other cells around the tumor were unaffected and that there didnt appear to be any toxic reactions to the treatment.
Its not yet known if the procedure would work in humans, but further research is likely to be done in a lot of areas, likely including other types of animals before tests can be conducted with human volunteers. Also, research is continuing to see if it might be possible to use antibodies to deliver other sorts of cancer killing agents, such as radiation.
If such types of photoimmunotherapy prove workable, millions of people the world over might be spared the pain of surgery and/or the harmful side effects of radiation and chemotherapy.
More information: Cancer cellselective in vivo near infrared photoimmunotherapy targeting specific membrane molecules, Nature Medicine (2011) doi:10.1038/nm.2554
Three major modes of cancer therapy (surgery, radiation and chemotherapy) are the mainstay of modern oncologic therapy. To minimize the side effects of these therapies, molecular-targeted cancer therapies, including armed antibody therapy, have been developed with limited success. In this study, we have developed a new type of molecular-targeted cancer therapy, photoimmunotherapy (PIT), that uses a target-specific photosensitizer based on a near-infrared (NIR) phthalocyanine dye, IR700, conjugated to monoclonal antibodies (mAbs) targeting epidermal growth factor receptors. Cell death was induced immediately after irradiating mAb-IR700bound target cells with NIR light. We observed in vivo tumor shrinkage after irradiation with NIR light in target cells expressing the epidermal growth factor receptor. The mAb-IR700 conjugates were most effective when bound to the cell membrane and produced no phototoxicity when not bound, suggesting a different mechanism for PIT as compared to conventional photodynamic therapies. Target-selective PIT enables treatment of cancer based on mAb binding to the cell membrane.
© 2011 PhysOrg.com
- Pancreas betrayed by 'double agent' May 30, 2011 | not rated yet | 0
- Artificial antibodies hold promise for fighting cancer, other diseases Oct 26, 2010 | not rated yet | 0
- Stem cells, potential source of cancer-fighting T cells Sep 20, 2011 | not rated yet | 0
- UV light improving chances of fighting cancer Oct 30, 2007 | not rated yet | 0
- Polymer Nanoparticle Kills Tumors Jan 12, 2006 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
Pressure-volume curve: Elastic Recoil Pressure don't make sense
May 18, 2013 From pressure-volume curve of the lung and chest wall (attached photo), I don't understand why would the elastic recoil pressure of the lung is...
If you became brain-dead, would you want them to pull the plug?
May 17, 2013 I'd want the rest of me to stay alive. Sure it's a lousy way to live but it beats being all-the-way dead. Maybe if I make it 20 years they'll...
MRI bill question
May 15, 2013 Dear PFers, The hospital gave us a $12k bill for one MRI (head with contrast). The people I talked to at the hospital tell me that they do not...
Ratio of Hydrogen of Oxygen in Dessicated Animal Protein
May 13, 2013 As an experiment, for the past few months I've been consuming at least one portion of Jell-O or unflavored Knox gelatin per day. I'm 64, in very...
Alcohol and acetaminophen
May 13, 2013 Edit: sorry for the typo in the title , can't edit I looked around on google quite a bit and it's very hard to find precise information on the...
Marie Curie's leukemia
May 13, 2013 Does anyone know what might be the cause of Marie Curie's cancer
- More from Physics Forums - Medical Sciences
More news stories
In a new study described in the journal Oncogene, researchers reveal how a key player in cell growth, immunity and the inflammatory response can be transformed into a primary contributor to tumor growth.
Cancer 1 hour ago | not rated yet | 0 |
A new study conducted using extensive medical records of over one million Israeli adolescents before military service shows clearly how exposure to the Israeli sun of young, light-skinned children increases substantially ...
Cancer 3 hours ago | not rated yet | 0
A new measure of the heterogeneity – the variety of genetic mutations – of cells within a tumor appears to predict treatment outcomes of patients with the most common type of head and neck cancer. In the May 20 issue ...
Cancer 7 hours ago | not rated yet | 0
Researchers at Mayo Clinic have developed a promising method to distinguish between pancreatic cancer and chronic pancreatitis—two disorders that are difficult to tell apart. A molecular marker obtained from pancreatic ...
Cancer 7 hours ago | not rated yet | 0
The use of a smartphone application significantly improves patients' preparation for a colonoscopy, according to new research presented today at Digestive Disease Week (DDW). The preparation process, which begins days in ...
Cancer May 19, 2013 | not rated yet | 0
Over the past few decades, neuroscientists have made much progress in mapping the brain by deciphering the functions of individual neurons that perform very specific tasks, such as recognizing the location ...
1 hour ago | not rated yet | 0 |
There is a link between use of anabolic-androgenic steroids and reduced mental health later in life. This is the main conclusion of a new study on elite male strength athletes that researchers from the University of Gothenburg ...
21 minutes ago | not rated yet | 0
High-intensity, short duration warm up activities at half time intervals boost athletic performance, a study of soccer players has found.
33 minutes ago | not rated yet | 0
(Medical Xpress)—Bullying because of perceived sexual orientation is prevalent among school-aged youths, according to a study led by Donald Patrick, professor of health services at the UW School of Public ...
53 minutes ago | not rated yet | 0
Patients suffering from chronic obstructive pulmonary disease (COPD) typically suffer from depression more frequently than those without COPD, resulting in higher levels of disability and illness and increasing the overall ...
1 hour ago | not rated yet | 0