Hydrogen peroxide provides clues to immunity, wound healing and tumor biology
Hydrogen peroxide isn't just that bottled colorless liquid in the back of the medicine cabinet that's used occasionally for cleaning scraped knees and cut fingers.
It's also a natural chemical in the body that rallies at wound sites, jump-starting immune cells into a series of events.
A burst of hydrogen peroxide causes neutrophils, the immune system's first responders, to rush to the wound to fight microorganisms, remove damaged tissue and then start the inflammation process.
University of Wisconsin-Madison researchers now have discovered the molecular sensor that detects wound-induced hydrogen peroxide and orchestrates the marshaling of neutrophils and other immune cells, or leukocytes, including those that affect tumors.
"Our findings suggest that in the future we might be able to manipulate the new pathway we've found to make immune cells go where we want them to," says lead author Dr. Anna Huttenlocher of the UW School of Medicine and Public Health (SMPH).
A tumor is a type of unhealed wound, says Huttenlocher. Tumors and wounds both generate high levels of hydrogen peroxide, and immune cells responsible for inflammation seek out wounds as well as tumors.
"We now speculate that the recruitment of immune cells for wound healing and tumor growth involves a different molecular pathway than recruitment of immune cells for fighting infections," says Huttenlocher, SMPH professor of pediatrics and of medical microbiology and immunology.
The researchers used transparent zebrafish larvae in a model they have developed to study immunity to watch neutrophils move to wounds in the tails of fish larvae.
They found that hydrogen peroxide modified a protein called Lyn, and that the modification let neutrophils go to wound sites along a specific cellular pathway.
"If we blocked Lyn, it's possible cells could still get to infection sites, where they could be helpful, but not to wounds or tumors, where they could be harmful," Huttenlocher says.
The experiments showed clearly that Lyn activation was dependent on hydrogen peroxide after tissue injury, and that blocking Lyn reduced the recruitment of neutrophils to wounds. Lyn is expressed specifically in leukocytes as a sensor for hydrogen peroxide.
Lyn is also a member of a powerful class of proteins known as Src family kinases (SFKs). Many of these kinases have been identified as cellular oncogenes, or precursors to cancer.
"Lyn bridges SFKs and the new pathway we have identified, broadly linking wound healing and immunity to changes in cell behavior in cancer," says Huttenlocher. "That connection may help move us forward with a better understanding of wound healing and cancer."
Lyn's connection to hydrogen peroxide should also elevate the chemical's status from the back of the medicine cabinet to a position of much greater interest.
Provided by University of Wisconsin-Madison
- The healing power of hydrogen peroxide May 24, 2011 | not rated yet | 0
- Experimental approach may improve healing of diabetic wounds and bed sores Feb 08, 2011 | not rated yet | 0
- Hydrogen peroxide marshals immune system (w/Video) Jun 03, 2009 | not rated yet | 0
- Hydrogen peroxide could cause absorbable sutures to come apart Jul 31, 2007 | not rated yet | 0
- Artificial skin system can heal wounds Dec 20, 2007 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
Why is zone 1 in liver more prone to ischemic injury?
May 23, 2013 Hi, Is it because around central vein, there is only deoxygenated blood from the vein where as in the periphery there is hepatic artery. Also why...
How can there be villous adenoma in colon, if there are no villi there
May 22, 2013 As title suggest. Thanks :smile:
How can there be a term called "intestinal metaplasia" of stomach
May 21, 2013 Hello everyone, Ok Stomach's normal epithelium is simple columnar, now in intestinal type of adenocarcinoma of stomach it undergoes "intestinal...
Pressure-volume curve: Elastic Recoil Pressure don't make sense
May 18, 2013 From pressure-volume curve of the lung and chest wall (attached photo), I don't understand why would the elastic recoil pressure of the lung is...
If you became brain-dead, would you want them to pull the plug?
May 17, 2013 I'd want the rest of me to stay alive. Sure it's a lousy way to live but it beats being all-the-way dead. Maybe if I make it 20 years they'll...
MRI bill question
May 15, 2013 Dear PFers, The hospital gave us a $12k bill for one MRI (head with contrast). The people I talked to at the hospital tell me that they do not...
- More from Physics Forums - Medical Sciences
More news stories
By discovering the new mechanism by which estrogen suppresses lipid synthesis in the liver, UC Irvine endocrinologists have revealed a potential new approach toward treating certain liver diseases.
Medical research 23 hours ago | not rated yet | 0 |
Aortic arch pulse wave velocity, a measure of arterial stiffness, is a strong independent predictor of disease of the vessels that supply blood to the brain, according to a new study published in the June issue the journal ...
Medical research 23 hours ago | not rated yet | 0
Since the discovery of Prontosil in 1932, sulfonamide antibiotics have been used to combat a wide spectrum of bacterial infections, from acne to chlamydia and pneumonia. However, their side effects can include serious neurological ...
Medical research May 23, 2013 | not rated yet | 0 |
Scientists at the National Institutes of Health report they have discovered in mouse studies that a small molecule released in the spinal cord triggers a process that is later experienced in the brain as ...
Medical research May 23, 2013 | 5 / 5 (3) | 0 |
Spanish researchers have discovered that the daily clearance of neutrophils from the body stimulates the release of hematopoietic stem cells from the bone marrow into the bloodstream, according to a report published today ...
Medical research May 23, 2013 | 5 / 5 (2) | 0
Two mutations central to the development of infantile myofibromatosis (IM)—a disorder characterized by multiple tumors involving the skin, bone, and soft tissue—may provide new therapeutic targets, according to researchers ...
6 minutes ago | not rated yet | 0 |
Kate O'Reilly's spring allergy survival kit includes the usual stuff - nasal sprays, allergy pills and a box of tissues. This season, she's added a new weapon to her line of defense: an app on her smartphone.
47 minutes ago | not rated yet | 0
(AP)—Government health officials are investigating several health problems reported with potentially contaminated medications made by a Tennessee specialty pharmacy.
55 seconds ago | not rated yet | 0
(Medical Xpress)—A new study by researchers in the US has shown that an ancient virus can be modified to help in the fight against the simian immunodeficiency virus SIV, which is the equivalent in monkeys ...
5 hours ago | 5 / 5 (3) | 0 |
Women at a particular stage in their monthly menstrual cycle may be more vulnerable to some of the psychological side-effects associated with stressful experiences, according to a study from UCL.
2 hours ago | not rated yet | 0 |
Biological processes are generally based on events at the molecular and cellular level. To understand what happens in the course of infections, diseases or normal bodily functions, scientists would need to ...
3 hours ago | 5 / 5 (2) | 0 |