Live-action films of worm sperm help researchers track critical fertility enzymes
This is a micrograph of a C. elegans ameoboid sperm. Credit: Aiza Go and Diana Chu
Compared to most other cells in an organism, sperm undergo a radical transformation to become compact and mobile delivery systems for paternal DNA. Even though sperm looks and moves quite differently across species, SF State researcher Diana Chu and colleagues now say that there are at least a few key enzymes that are critical for sperm development and mobility in species as different as mice and nematode worms.
The study by Chu, et al., was published today online by the journal Genetics.
These enzymes (called PP1 phosphatases) are multitaskers in the nematode, which Chu and the others discovered through unique live-action films of the enzymes at work. First, the enzymes help to separate chromosomes during sperm cell division. After that, they play a role in the development of the sperm's pseudopodsthe appendages that nematode sperm use to move. Pseudopods propel the sperm with a "treadmilling" motion, and the enzymes help disassemble the cell's inner skeleton in a way that pushes the treadmilling forward.
Fluorescent images of C. elegans sperm. Shown in red are GSP-3/4, phosphatases required for fertility, white are membranous organelles and green is major sperm protein, a C. elegans protein important for motility. GSP-3/4 is shown to be an important regulator of MSP in the Wu et al. paper. Credit: Jui-ching Wu and Diana ChuSperm in mammals like miceand mendon't have pseudopods and don't move in the same way, but they still rely on the phosphatases for development and mobility. Further study of the phosphatases could someday shed light on some of the causes of human infertility, since the enzymes seem to be critical for sperm function.
More information: "PP1 phosphatases regulate multiple stages of sperm development and motility in Caenorhabditis elegans," published in advance online by Genetics. www.genetics.org/c… early/recent
Provided by San Francisco State University
- Proteins in sperm unlock understanding of male infertility says new study Oct 08, 2008 | not rated yet | 0
- Viagra could be harmful to fertility Feb 25, 2008 | not rated yet | 0
- Worm sperm gives clue to male infertility Sep 05, 2006 | not rated yet | 0
- Rodent sperm work together for better results Jan 24, 2007 | not rated yet | 0
- Researchers Develop Test to Identify 'Best' Sperm May 20, 2010 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
Classical and Quantum Mechanics via Lie algebras
Apr 15, 2011 I'd like to open a discussion thread for version 2 of the draft of my book ''Classical and Quantum Mechanics via Lie algebras'', available online at http://lanl.arxiv.org/abs/0810.1019 , and for the...
- More from Physics Forums - Independent Research
More news stories
University of Minnesota Medical School researchers from the Masonic Cancer Center, University of Minnesota, in partnership with the University's Brain Tumor Program, have developed a new mouse model of malignant peripheral ...
Genetics 11 hours ago | 5 / 5 (1) | 0 |
Northwestern University scientists have shown a gene involved in neurodegenerative disease also plays a critical role in the proper function of the circadian clock.
Genetics May 16, 2013 | 3 / 5 (1) | 1 |
Informed consent is the backbone of patient care. Genetic testing has long required patient consent and patients have had a "right not to know" the results. However, as 21st century medicine now begins to use the tools of ...
Genetics May 16, 2013 | 5 / 5 (1) | 3 |
Ethicists provide framework supporting new recommendations on reporting incidental findings in gene sequencing
In a paper published in Science Express, a group of experts led by bioethicists in the Center for Medical Ethics and Health Policy at Baylor College of Medicine provide a framework for the new American College of Medical Geneti ...
Genetics May 16, 2013 | not rated yet | 0
The use of genome-wide analysis (GWA), where the entirety of an individual's DNA is examined to look for the genomic mutations or variants which can cause health problems is a massively useful technology for diagnosing disease. ...
Genetics May 16, 2013 | not rated yet | 0
A Nobel prize-winning scientist Tuesday played down "shock-horror scenarios" that a new virus strain will emerge with the potential to kill millions of people.
37 minutes ago | 5 / 5 (1) | 0
No new human cases of the H7N9 virus have been recorded in China for a week, national health authorities said, for the first time since the outbreak began in March.
19 minutes ago | not rated yet | 0
Johns Hopkins researchers say they have discovered specific chemical alterations in two genes that, when present during pregnancy, reliably predict whether a woman will develop postpartum depression.
1 hour ago | not rated yet | 0 |
(Medical Xpress)—A research team, led by Jeremy Barr, a biology post-doctoral fellow, unveils a new immune system that protects humans and animals from infection.
11 hours ago | 4.6 / 5 (13) | 5 |
Children who have suffered maltreatment are 36% more likely to be obese in adulthood compared to non-maltreated children, according to a new study by King's College London. The authors estimate that the prevention or effective ...
1 hour ago | not rated yet | 0
New research suggests that a compound abundant in the Mediterranean diet takes away cancer cells' "superpower" to escape death. By altering a very specific step in gene regulation, this compound essentially re-educates cancer ...
13 hours ago | 4.8 / 5 (12) | 2 |