Researchers achieve male fertility breakthrough

November 15, 2011

A Ben-Gurion University of the Negev researcher has achieved a significant breakthrough in male fertility, producing normal sperm from mouse cells.

"This study may open new therapeutic strategies for who cannot generate sperm and/or pre-pubertal cancer patients at risk of infertility due to aggressive chemo- or radiotherapy and cannot cryopreserve sperm as in adult patients," explains Prof. Mahmoud Huleihel, of BGU's Shraga Segal Department of Microbiology and Immunology in the Faculty of Health Sciences.

The article was just published online in Nature's Asian Journal of Andrology, and according to the authors is "the first original report revealing the generation of morphologically normal spermatozoa from mouse testicular ." It outlines the generation of spermatozoa from mouse testicular germ cells under in vitro culture.

Huleihel and his team used a three-dimensional Soft Agar Culture System (SACS) to generate the sperm. Previously, Huleihel pioneered the use of SACS for spermatogenesis in vitro.

The study was performed in cooperation with Prof. Eitan Lunenfeld, Soroka University Medical Center, Beer-Sheva, and Prof. Stefan Schlatt, University of Münster, Münster, Germany. It was partially supported by a grant from the German–Israel Foundation.

Explore further: Study: Sperm banks unpopular with patients

More information: www.nature.com/aja/journal/vaop/ncurrent/full/aja2011112a.html

Related Stories

Treating male infertility with stem cells

March 2, 2007

New research has examined the usefulness of bone marrow stem cells for treating male infertility, with promising results. The related report by Lue et al, “Fate of bone marrow stem cells transplanted into the testis: potential ...

Researchers Reprogram Human Induced Pluripotent Stem Cells

January 27, 2009

For the first time, UCLA researchers have reprogrammed human induced pluripotent stem (iPS) cells into the cells that eventually become eggs and sperm, possibly opening the door for new treatments for infertility using patient-specific ...

Japanese sperm cell breakthrough offers hope to infertile men

March 24, 2011

(PhysOrg.com) -- In what can only be described as cosmic forces at work, Japanese scientists working at Yokohama University, just south of Tokyo, have in the midst of a national crises, announced a major breakthrough in fertility ...

Making sperm from stem cells in a dish

August 4, 2011

Researchers have found a way to turn mouse embryonic stem cells into sperm. This finding, reported in the journal Cell in a special online release on August 4th, opens up new avenues for infertility research and treatment. ...

Recommended for you

Basic research fuels advanced discovery

August 26, 2016

Clinical trials and translational medicine have certainly given people hope and rapid pathways to cures for some of mankind's most troublesome diseases, but now is not the time to overlook the power of basic research, says ...

New method creates endless supply of kidney precursor cells

August 25, 2016

Salk Institute scientists have discovered the holy grail of endless youthfulness—at least when it comes to one type of human kidney precursor cell. Previous attempts to maintain cultures of the so-called nephron progenitor ...

New avenue for understanding cause of common diseases

August 25, 2016

A ground-breaking Auckland study could lead to discoveries about many common diseases such as diabetes, cancer and dementia. The new finding could also illuminate the broader role of the enigmatic mitochondria in human development.

Strict diet combats rare progeria aging disorders

August 25, 2016

Mice with a severe aging disease live three times longer if they eat thirty percent less. Moreover, they age much healthier than mice that eat as much as they want. These are findings of a joint study being published today ...

1 comment

Adjust slider to filter visible comments by rank

Display comments: newest first

cyberCMDR
not rated yet Nov 16, 2011
Imagine the next step here, generating viable germ cells from any adult cell. That would have the potential to change everything. China would be distributing eggs derived from all their athletes and geniuses to whichever family wanted them, making the mother's genetic contribution irrelevant. Every man could have children whose other "parent" was a star in some field of endeavor. Other nations would have to do the same to keep up, or to improve their competitive edge. There would be a black market in cell samples from movie stars. Lots of possible repercussions, if that next step happens.

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.