Tropical areas aren't the only source of seasonal flu epidemics: study

A commonly held theory says that flu virus originates every year in Southeast and Eastern Asia, making this region the source of seasonal flu epidemics in other parts of the world.

However, researchers at Duke-NUS Graduate Medical School in Singapore have found that in isn't the only global source of flu epidemics. The international team of scientists involved in the work found that any one of the urban centers they studied could act as a source for a in any other locality.

"We found that these regions are just one node in a network of urban centers connected by air travel, through which flu virus circulates and causes a series of local epidemics that overlap in time," said Gavin Smith, PhD, senior author and Associate Professor in the Program in at Duke-NUS.

The study was published the week of Nov. 14 in the online Early Edition of the .

The research team chose to study influenza A because it is much more prevalent than both influenza B and C. Influenza is a significant cause of human illness and death worldwide – the World Health Organization estimates that 250,000 to 500,000 influenza A related deaths occur per year worldwide, and about 49,000 deaths occur in the United States.

The team obtained RNA sequences of virus samples from 2003 to 2006 in Australia, Europe, Japan, New York, New Zealand and Southeast Asia, as well as some more recently sequenced viruses from Hong Kong. The virus populations from tropical Southeast Asia and Hong Kong showed relatively low levels of genetic diversity and no seasonal fluctuations in comparison with nnual temperate-area epidemics.

The analysis used time and space parameters to reveal high rates of viral migration among the urban centers tested. Although the virus population that migrated between Southeast Asia and Hong Kong persisted through time, the pattern of infections also depended on virus input from temperate regions that have distinct seasons. None of the temperate and tropical regions they examined was the source of all of the new flu strains in a given year.

The scientists showed that multiple lineages of a virus could seed annual flu epidemics, and that each region could function as a potential source population.

Current strategies for controlling through vaccination are based on biannual selection of vaccine candidates for the Northern and Southern hemispheres, and these plans require an understanding of circulating viruses.

"While current vaccine-strain selection strategies are generally effective, the results of our study could potentially be used to improve this process by incorporating knowledge of migration and connections between regions," said lead author Justin Bahl, Ph.D., Assistant Professor in the Duke-NUS Program in Emerging .

Many examples of the global movement of viruses facilitated by air travel exist, including the SARS epidemic and the H1N1 pandemic in 2009, Smith said. "Larger regions with greater connectedness may potentially contribute more to the global diversity of influenza viruses circulating."

The researchers plan to build on this study by generating new data from areas where there is currently little or no genetic information available. This work forms part of a larger effort to understand the patterns and mechanisms of transmission of respiratory viruses in humans, using as a model system, Bahl said.

Related Stories

NIH experts describe influenza vaccines of the future

Nov 17, 2010

In a review article appearing in the New England Journal of Medicine, scientists at the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, examine research under way to ...

Influenza in Africa should not be ignored

Dec 15, 2009

Influenza is circulating in Africa, but virtually no information or attention is evident, says a new essay in this week's PLoS Medicine. Maria Yazdanbakhsh and Peter Kremsner argue that the lack of adequate surveillance means ...

Recommended for you

Asthma drug may help those with chronic hives

9 hours ago

(HealthDay)—A drug already used to treat moderate-to-severe allergic asthma appears to offer relief to people with chronic hives who haven't been helped by standard medications, new research suggests.

Study compares deep vein thrombosis therapies (Update)

11 hours ago

Patients who have a clot in their legs and are considering whether to be treated with traditional blood-thinning medication or undergo a minimally-invasive catheter-based clot removal procedure should feel comfortable that ...

Automated models can identify acute back pain in EMRs

13 hours ago

(HealthDay)—Administrative data models can discriminate acute low back pain (LBP) from nonacute cases in electronic medical records (EMRs), according to a study published in the June 15 issue of Spine.

Potential new flu drugs target immune response, not virus

16 hours ago

The seriousness of disease often results from the strength of immune response, rather than with the virus, itself. Turning down that response, rather than attacking the virus, might be a better way to reduce that severity, ...

User comments