WTC workers exposed earlier to dust cloud have higher risk of atherosclerotic lesions

In the first study using magnetic resonance imaging (MRI) to evaluate cardiovascular risk in World Trade Center (WTC) first responders, researchers from Mount Sinai School of Medicine have found that the responders who experienced high levels of exposure to the initial dust cloud on September 11, 2001, demonstrate high-risk features of atherosclerosis (plaque in arteries). The data was presented at the American Heart Association's Scientific Sessions 2011 in Orlando, Florida.

Mary Ann McLaughlin, MD, MPH, Associate Professor of Medicine is the primary investigator for this study and has been evaluating the cardiovascular health of the WTC responders since 2007. In addition to the current study, her research has shown more impaired cardiac relaxation and coronary calcification in responders at Ground Zero, compared with the general population.

First author, Venkatesh Mani, PhD, and colleagues, used MRI to evaluate the blood vessels of 19 responders exposed to the high levels of particulate matter from the , and 12 exposed to the lower levels. They found that WTC workers who were exposed to the initial dust cloud had higher in their artery plaque compared to people with lower exposure. Co-investigator, Simonette Sawit, MD also demonstrated impaired vascular reactivity, or dysfunction of the inner lining of blood vessels, in those with higher dust exposure. This dysfunction may accelerate the progression of atherosclerosis. The Mount Sinai team discovered this association in WTC workers independent of other clinical factors.

"Using noninvasive , we were able to see a significant impact of the events of 9/11 on the cardiovascular health of the brave men and women who responded that day," said Zahi Fayad, PhD, Professor of Radiology, and Medicine in the Division of Cardiology, and the Director of the Translational and Molecular Imaging Institute at Mount Sinai School of Medicine. "Now that we have visualized the risk and early development of vascular lesions, in a subset of subjects, we look forward to studying the use of imaging in the greater patient population."

"This study defines physiologic change associated with greater exposure to the dust cloud at the WTC site," said Dr. McLaughlin. "We are currently evaluating other predictors of in this population to gain a better understanding of the impact of particulate matter exposure on cardiovascular health."

Provided by The Mount Sinai Hospital

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