Beneficial or not beneficial: that is the question for IL-1 inhibition in atherosclerosis
December 27, 2011 in Medical researchAtherosclerosis is a disease of the major arterial blood vessels. It is one of the major causes of heart attack and stroke.
The proinflammatory molecule IL-1 has been linked to atherosclerosis and a clinical trial has been launched in which an antibody specific for IL-1-beta is being studied for its effects on the severe clinical complications of atherosclerosis (i.e., heart attack and stroke).
However, a team of researchers led by Gary Owens, at the University of Virginia, Charlottesville, has now generated data in mice that raise potential concerns about this clinical trial — Owens and colleagues find that IL-1 limits the features of advanced atherosclerosis that are linked to the severe complications of the disease in humans.
More information: Genetic inactivation of IL-1 signaling enhances atherosclerotic plaque instability and reduces outward vessel remodeling in advanced atherosclerosis in mice, Journal of Clinical Investigation.
Journal reference:
Journal of Clinical Investigation
Provided by Journal of Clinical Investigation
-
New potential atherosclerosis risk marker discovered
Apr 11, 2011 |
not rated yet |
0
-
Research explains link between cholesterol and heart disease
Sep 18, 2007 |
not rated yet |
0
-
'At-TRIB(1)-uting' a gene a new function in the liver
Nov 15, 2010 |
not rated yet |
0
-
Dendritic cell subtype protects against atherosclerosis
Nov 10, 2011 |
not rated yet |
0
-
New atherosclerosis vaccine gives promising results
May 06, 2010 |
not rated yet |
0
-
Of mice and mental models: Neuroscientific implications of risk-optimized behavior in the mouse
May 25, 2012 |
not rated yet |
0
-
Limits to growth: Scientists identify key metastasis-enabling enzyme
May 22, 2012 |
5 / 5 (4) |
0
-
Seeing is as seeing does: Spatially-structured retinal input in early development of cortical maps
Apr 26, 2012 |
5 / 5 (4) |
1
-
Dreamless nights: Brain activity during nonrapid eye movement sleep
Apr 09, 2012 |
4.4 / 5 (12) |
0
-
Take your time: Neurobiology sheds light on the superiority of spaced vs. massed learning
Mar 28, 2012 |
4.5 / 5 (21) |
3
-
Potential Breakthrough in Seizure Control
15 hours ago
-
Popping/Cracked sternum.
20 hours ago
-
Which Mental Illness Encompasses This Problem?
20 hours ago
-
A question about drug tolerance
May 23, 2012
-
Poor nutrition leading to overeating?
May 23, 2012
-
Math and dyslexia?
May 21, 2012
- More from Physics Forums - Medical Sciences
More news stories
Implantable pain disk may help those with cancer
An estimated 3.5 million cancer patients around the globe are in severe pain from their disease, but many get no relief.
Medical research
May 25, 2012 |
not rated yet |
0
|
Energy levels link sleep control mechanisms
Sleep, or lack of it, can determine level of cognitive performance which is linked with accidents as well as increased risk of serious health problems. Links between cell energy levels, gene transcription ...
Medical research
May 25, 2012 |
not rated yet |
0
Researchers identify key brain cell in antidepressant action
(Medical Xpress) -- Antidepressant medications such as Prozac have helped improve mood and lessen anxiety in millions of people with major depression. But scientists know surprisingly little about how these drugs work.
Medical research
May 25, 2012 |
4.7 / 5 (3) |
0
|
Rockefeller scientists pioneer new method to determine mechanisms of drug action
(Medical Xpress) -- Knowing that a drug works is great. Knowing how it works is a luxury. And until now, determining a drug’s mechanism of action has been a tedious and difficult process for scientists.
Medical research
May 25, 2012 |
not rated yet |
0
|
Like curry? New biological role identified for compound used in ancient medicine
Scientists have just identified a new reason why some curry dishes, made with spices humans have used for thousands of years, might be good for you.
Medical research
May 25, 2012 |
4.5 / 5 (12) |
2
|
Keep food safety in mind this memorial day weekend
(HealthDay) -- Picnics, parades and cookouts are as much a part of Memorial Day weekend as tributes to the United States' war veterans.
Travel to high altitudes tied to Crohn's, colitis flare-ups
(HealthDay) -- People with inflammatory bowel disease, which includes Crohn's disease and colitis, may be at increased risk for flare-ups when they fly or travel to high altitudes for skiing or mountain climbing, ...
Family history of Alzheimer's affects functional connectivity
(HealthDay) -- Cognitively normal individuals with a family history of late-onset Alzheimer's disease (AD) may display lower resting state functional connectivity in the default mode network (DMN) of the brain, ...
Transvaginal mesh op restores pelvic organ prolapse at price
(HealthDay) -- Transvaginal mesh (TVM) procedures are effective for anatomical restoration of pelvic organ prolapse (POP), but patients report a worsening of sexual function following surgery, according to ...
Of mice and mental models: Neuroscientific implications of risk-optimized behavior in the mouse
(Medical Xpress) -- Regardless of an organism’s biological complexity, every encephalized animal continuously makes under-informed behavioral choices that can have serious consequences. Despite its ubiquity, ...
Weight struggles? Blame new neurons in your hypothalamus
New nerve cells formed in a select part of the brain could hold considerable sway over how much you eat and consequently weigh, new animal research by Johns Hopkins scientists suggests in a study published in the May issue ...
