Beneficial or not beneficial: that is the question for IL-1 inhibition in atherosclerosis
Atherosclerosis is a disease of the major arterial blood vessels. It is one of the major causes of heart attack and stroke.
The proinflammatory molecule IL-1 has been linked to atherosclerosis and a clinical trial has been launched in which an antibody specific for IL-1-beta is being studied for its effects on the severe clinical complications of atherosclerosis (i.e., heart attack and stroke).
However, a team of researchers led by Gary Owens, at the University of Virginia, Charlottesville, has now generated data in mice that raise potential concerns about this clinical trial Owens and colleagues find that IL-1 limits the features of advanced atherosclerosis that are linked to the severe complications of the disease in humans.
More information: Genetic inactivation of IL-1 signaling enhances atherosclerotic plaque instability and reduces outward vessel remodeling in advanced atherosclerosis in mice, Journal of Clinical Investigation.
Journal reference: Journal of Clinical Investigation
Provided by Journal of Clinical Investigation
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