Drugs used to overcome cancer may also combat antibiotic resistance: researchers

December 22, 2011 by Gerry Wright

Drugs used to overcome cancer may also combat antibiotic resistance, finds a new study led by Gerry Wright, scientific director of the Michael G. DeGroote Institute for Infectious Disease Research at McMaster University.

"Our study found that certain proteins, called , that confer antibiotic resistance are structurally related to proteins important in cancer," says Wright about the study published in Chemistry & Biology.

"The pharmaceutical sector has made a big investment in targeting these proteins, so there are a lot of compounds and drugs out there that, although they were designed to overcome cancer, they can in fact be looked at with fresh eyes and maybe repurposed to address the problem of antibiotic resistance."

The large-scale study involved screening 14 antibiotic resistant molecules against 80 chemically diverse protein kinase inhibitors.

Antibiotic resistance is a problem growing in global scope, as more viruses have overcome currently available antibiotics.

"As a result, new drugs and antibiotic strategies are urgently needed to fill the gap in infectious disease control," says Wright, adding he hopes future studies in combination therapies will provide new insight into .

"One of the challenges facing the drug discovery community is the lack of new chemical scaffolds with antibiotic activity. This has led to the open question of whether all easily implementable antibiotic chemical scaffolds have already been exploited over the last 50 years: the so-called ''low hanging fruit''."

Related Stories

A world without antibiotics?

April 7, 2011

Imagine a world without antibiotics. Common infections are life threatening. Pneumonia, urinary tract infections and venereal diseases are incurable. Cancer chemotherapies do not exist. The life expectancy for Canadian men ...

Roads pave the way for the spread of superbugs

September 29, 2011

Antibiotic resistant E. coli was much more prevalent in villages situated along roads than in rural villages located away from roads, which suggests that roads play a major role in the spread or containment of antibiotic ...

Recommended for you

Crystal clear images uncover secrets of hormone receptors

July 31, 2015

Many hormones and neurotransmitters work by binding to receptors on a cell's exterior surface. This activates receptors causing them to twist, turn and spark chemical reactions inside cells. NIH scientists used atomic level ...

A cheaper, high-performance prosthetic knee

July 30, 2015

In the last two decades, prosthetic limb technology has grown by leaps and bounds. Today, the most advanced prostheses incorporate microprocessors that work with onboard gyroscopes, accelerometers, and hydraulics to enable ...

Flow means 'go' for proper lymph system development

July 27, 2015

The lymphatic system provides a slow flow of fluid from our organs and tissues into the bloodstream. It returns fluid and proteins that leak from blood vessels, provides passage for immune and inflammatory cells from the ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.