Patient receives first prescription for FDA-approved brain tumor treatment
(Medical Xpress) -- The University of Illinois Hospital is the first center in North America to prescribe a new FDA-approved treatment for patients with the most common and aggressive type of brain tumor, glioblastoma multiforme, or GBM.
The hospital is one of the first centers in the U.S. to receive training and certification to treat patients with recurrent GBM with a new therapy called Tumor Treating Fields. This novel, non-invasive therapy is provided using a portable device, the NovoTTF-100A System made by Novocure, which uses alternating electrical fields to disrupt the rapid cell division exhibited by cancer cells.
David Messmer, 50, of Indiana is the first patient in the country to receive a prescription for the device outside of a clinical trial. He began treatment with the Novocure device Nov. 28 at the University of Illinois Hospital.
Messmer was diagnosed with GBM in November of last year. His tumor has continued to progress despite two surgeries, chemotherapy and radiation. With the support of his family, he says he was willing to try anything."
"Chemo is just not working for me," Messmer said. "This is my next best hope."
GBM affects approximately 10,000 Americans each year. The median survival time from initial diagnosis is 15 months with optimal treatment, and median survival from the time of recurrence is only three to five months without additional effective treatment.
"Patients with recurrent GBM present a significant treatment challenge, says Dr. Herbert Engelhard, chief of neuro-oncology at the University of Illinois Hospital, which was one of the primary clinical research sites for the approval trial. The clinical trial, Engelhard said, showed that patients treated with the NovoTTF had comparable median overall survival times, fewer side effects, and better quality-of-life scores compared to patients treated with chemotherapy.
"We are proud to work with Novocure to make this state-of-the-art therapy available to those GBM patients who need it," he said.
TTF therapy provides physicians with a fourth treatment option for cancer in addition to surgery, radiation therapy and chemotherapy. It has been shown to effectively inhibit tumor growth by inducing cell death. The NovoTTF is a portable, non-invasive medical device designed for continuous use throughout the day by the patient. The device is placed directly on the skin near the tumor. It creates an artificial, alternating electric field within the tumor, which disrupts cancer cell division and can cause complete destruction of the dividing cancer cells. The most commonly reported side effect was a mild-to-moderate rash beneath the electrodes.
The U.S. Food and Drug Administration has approved the NovoTTF-100A System for use as a treatment for adult patients with recurrent GBM. The device is intended to be used alone as an alternative to standard medical therapy for GBM after surgical and radiation options have been exhausted.
Provided by University of Illinois at Chicago
- Clinical Trial to Treat Brain Tumors with Electric Fields Jun 04, 2010 | not rated yet | 0
- Studies show novel device may enhance chemotherapy treatment in brain tumors Nov 24, 2008 | not rated yet | 0
- TTF and chemotherapy increase survival for patients with advanced non-small cell lung cancer Oct 10, 2010 | not rated yet | 0
- FDA clears first-of-a-kind device for brain cancer Apr 15, 2011 | not rated yet | 0
- Phase I trial begins using gene therapy and bone marrow stem cells in the treatment of brain cancer Nov 14, 2011 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
Why is zone 1 in liver more prone to ischemic injury?
10 hours ago Hi, Is it because around central vein, there is only deoxygenated blood from the vein where as in the periphery there is hepatic artery. Also why...
How can there be villous adenoma in colon, if there are no villi there
May 22, 2013 As title suggest. Thanks :smile:
How can there be a term called "intestinal metaplasia" of stomach
May 21, 2013 Hello everyone, Ok Stomach's normal epithelium is simple columnar, now in intestinal type of adenocarcinoma of stomach it undergoes "intestinal...
Pressure-volume curve: Elastic Recoil Pressure don't make sense
May 18, 2013 From pressure-volume curve of the lung and chest wall (attached photo), I don't understand why would the elastic recoil pressure of the lung is...
If you became brain-dead, would you want them to pull the plug?
May 17, 2013 I'd want the rest of me to stay alive. Sure it's a lousy way to live but it beats being all-the-way dead. Maybe if I make it 20 years they'll...
MRI bill question
May 15, 2013 Dear PFers, The hospital gave us a $12k bill for one MRI (head with contrast). The people I talked to at the hospital tell me that they do not...
- More from Physics Forums - Medical Sciences
More news stories
Treating pediatric leukemia patients with a liposomal formulation of anthracycline-based chemotherapy at a more intense-than-standard dose during initial treatment may result in high survival rates without causing any added ...
Cancer 2 hours ago | not rated yet | 0
Scientists have uncovered a survival mechanism that occurs in breast cells that have just turned premalignant-cells on the cusp between normalcy and cancers-which may lead to new methods of stopping tumors.
Cancer 3 hours ago | not rated yet | 0 |
Frequent heartburn was positively associated with cancers of the throat and vocal cord among nonsmokers and nondrinkers, and the use of antacids, but not prescription medications, had a protective effect, according to data ...
Cancer 3 hours ago | not rated yet | 0
Aggressive forms of bladder cancer involve the protein PODXL – a discovery that could hold the key to improved treatment, according to researchers at Lund University, Uppsala University and KTH in Sweden.
Cancer 5 hours ago | 5 / 5 (1) | 0
An anti-cancer drug reverses memory deficits in an Alzheimer's disease mouse model, University of Pittsburgh Graduate School of Public Health researchers confirm in the journal Science.
55 minutes ago | not rated yet | 0 |
Can economic incentives such as gift cards, T-shirts, and time off from work motivate members of the public to increase their donations of blood?
1 hour ago | not rated yet | 0 |
Scientists at the National Institutes of Health report they have discovered in mouse studies that a small molecule released in the spinal cord triggers a process that is later experienced in the brain as the sensation of ...
1 hour ago | 5 / 5 (1) | 0 |
Teams of highly respected Alzheimer's researchers failed to replicate what appeared to be breakthrough results for the treatment of this brain disease when they were published last year in the journal Science.
1 hour ago | not rated yet | 0 |
A brief visual task can predict IQ, according to a new study. This surprisingly simple exercise measures the brain's unconscious ability to filter out visual movement. The study shows that individuals whose ...
2 hours ago | 4.8 / 5 (4) | 0 |
Little is known about why asthma develops, how it constricts the airway or why response to treatments varies between patients. Now, a team of researchers at Weill Cornell Medical College, Columbia University Medical Center ...
1 hour ago | not rated yet | 0 |