Radiation-induced damage to brain tissue reversed by oxygen starvation in mice
Treating brain tumors with whole brain radiation therapy can damage healthy brain tissue, but a new study in mice reveals that limiting the oxygen supply, or hypoxia, can alleviate some of the cognitive impairment caused by the radiation. The results are reported in the Jan. 18 issue of the online journal PLoS ONE.
The researchers, led by William Sonntag of University of Oklahoma, exposed the mice to a clinically relevant regimen of radiation, which caused progressive deterioration of spatial learning starting about two months post-radiation.
However, when mice were treated with chronic hypoxia for about three weeks, beginning one month after radiation exposure, they showed significant improvement in this area, which was maintained for at least two months after returning to normal oxygen levels.
The radiation treatment also caused an early decline in contextual learning and memory, but these deficiencies were transient and dissipated within three months post-radiation.
More information: Warrington JP, Csiszar A, Mitschelen M, Lee YW, Sonntag WE (2012) Whole Brain Radiation-Induced Impairments in Learning and Memory Are Time-Sensitive and Reversible by Systemic Hypoxia. PLoS ONE 7(1): e30444. doi:10.1371/journal.pone.0030444
Provided by
Public Library of Science
-
Stem cells restore cognitive abilities impaired by brain tumor treatment, study finds
Nov 09, 2009 |
not rated yet |
0
-
Stem cells restore cognitive abilities impaired by brain cancer treatment
Jul 13, 2011 |
not rated yet |
0
-
Exercise can aid recovery after brain radiation
Oct 18, 2009 |
not rated yet |
0
-
Stem cells alleviate tumor treatment side effects
Nov 17, 2009 |
not rated yet |
0
-
Hyperoxia may slow formation of wrinkles
Jun 29, 2010 |
not rated yet |
0
-
Motion perception revisited: High Phi effect challenges established motion perception assumptions
Apr 23, 2013 |
3 / 5 (2) |
2
-
Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update)
Apr 02, 2013 |
4.5 / 5 (11) |
5
-
The visual system as economist: Neural resource allocation in visual adaptation
Mar 30, 2013 |
5 / 5 (2) |
9
-
Separate lives: Neuronal and organismal lifespans decoupled
Mar 27, 2013 |
4.9 / 5 (8) |
0
-
Sizing things up: The evolutionary neurobiology of scale invariance
Feb 28, 2013 |
4.8 / 5 (10) |
14
-
Classical and Quantum Mechanics via Lie algebras
Apr 15, 2011
- More from Physics Forums - Independent Research
More news stories
Vermont becomes third US state to legalize assisted suicide
Vermont became on Monday the third US state to legalize physician-assisted suicide.
Other
24 minutes ago |
not rated yet |
0
Food laboratory accuracy remains a concern
Food microbiology laboratories continue to submit false negative results and false positive results on a routine basis. A retrospective study of nearly 40,000 proficiency test results over the past 14 years, presented today ...
Other
5 hours ago |
not rated yet |
0
Wireless ultrasound transducers help physicians
Siemens has presented the world's first ultrasound system with wireless transducers. The system's transducers, which can be easily operated with one hand, transmit ultrasound images via radio waves to the ...
Other
10 hours ago |
not rated yet |
0
Flesh-eating disease victim gets prosthetic hands
(AP)—A woman who lost both hands, her left leg and right foot after contracting a flesh-eating disease has been fitted with prosthetic hands.
Other
May 18, 2013 |
not rated yet |
0
Illinois Senate approves medical marijuana bill
(AP)—Medical marijuana use in Illinois is now in Gov. Pat Quinn's hands after the state Senate approved legislation.
Other
May 17, 2013 |
5 / 5 (1) |
1
Researchers develop model for better testing, targeting of malignant peripheral nerve sheath tumors
University of Minnesota Medical School researchers from the Masonic Cancer Center, University of Minnesota, in partnership with the University's Brain Tumor Program, have developed a new mouse model of malignant peripheral ...
Practice makes perfect? Not so much
Turns out, that old "practice makes perfect" adage may be overblown. New research led by Michigan State University's Zach Hambrick finds that a copious amount of practice is not enough to explain why people ...
Older prostate cancer patients should think twice before undergoing treatment
Older prostate cancer patients with other underlying health conditions should think twice before committing to surgery or radiation therapy for their cancer, according to a multicenter study led by researchers in the UCLA ...
New test better detects elephantiasis worm infection
A new diagnostic test for a worm infection that can lead to severe enlargement and deformities of the legs and genitals is far more sensitive than the currently used test, according to results of a field ...
Study shows that women who smoke during pregnancy increase the risk of both obesity and gestational diabetes in their da
Women who smoke during pregnancy increase the risk of both obesity and gestational diabetes, in their daughters, concludes research published in Diabetologia, the journal of the European Association for the Study of Diabet ...
Leading researchers report on the elusive search for biomarkers in Huntington's disease
While Huntington's disease (HD) is currently incurable, the HD research community anticipates that new disease-modifying therapies in development may slow or minimize disease progression. The success of HD research depends ...
