UH Case Medical Center offers new therapy for gynecologic cancer patients

Patients with gynecologic cancer have new hope in a novel technology now offered at the Seidman Cancer Center at University Hospitals (UH) Case Medical Center. A team of cancer specialists, led by Robert DeBernardo, MD, is among the first in the nation to launch a dedicated program using Hyperthermic Intraperitoneal Chemotherapy (HIPEC) to treat ovarian, endometrial and select other cancers.

Performed immediately following surgery, HIPEC delivers heated through a 'hot bath' into the , where it can penetrate directly. After the surgeon removes as much visible cancer as possible, a heated, a sterilized chemotherapy solution is circulated throughout the abdomen through a technologically sophisticated perfusion system to destroy the remaining cancer cells.

"This is a new and potentially revolutionary way of treating women with gynecologic cancers, which tend to be quite responsive to chemotherapy," says Dr. DeBernardo, at UH Case and Assistant Professor at Case Western Reserve University School of Medicine. "Our preliminary data and experience has been overwhelmingly positive and the therapy has been well-tolerated and effective. HIPEC promises to extend lives in a meaningful way."

HIPEC has been used for years in patients with colon, pseudomyxomas and appendiceal cancers as well as mesothelioma, cancers that in general are not responsive to chemotherapy, but it is now viewed as a promising new treatment for gynecologic malignancy.

UH Case Medical Center plans to launch several Phase One trials for patients this spring, including a first-of-its kind study involving the use of heated chemotherapy for ovarian cancer that has spread to the thoracic cavity, a procedure called Hyperthermic Intrathoracic Chemotherapy (HITEC). These hard-to-treat cancers typically recur and HITEC is performed after minimally invasive lung surgery.

There are several advantages to HIPEC compared to traditional chemotherapy, including improved survival rates for gynecologic cancer patients. Previous studies on the use of chemotherapy given directly into the abdomen, known as intraperitoneal (IP) chemotherapy, have shown an extension of women's lives with advanced on average of 1.5 years longer than women receiving intravenous (IV) treatment.

HIPEC allows a much higher dose of chemotherapy to permeate the diseased tissue. Because conventional chemotherapy is usually administered intravenously, it circulates throughout the body and is diluted by the time it reaches the abdomen.

"Despite the obvious benefits, only a minority of women currently receive IP therapy due to practical difficulties involved in administering chemo directly in the abdomen following surgery," says Dr. DeBernardo. "HIPEC is now viewed as the next logical step in treating such as recurrent and new ovarian and certain endometrial cancers."

Additionally, there has been strong research demonstrating that heating the solution (hyperthermia) also enhances the power of the chemotherapy, improving absorption by tumors and susceptibility of . Furthermore, because chemotherapy is kept within the abdomen, HIPEC minimizes the rest of the body's exposure to the treatment, which helps reduce some side effects such as hair loss.

In addition to gynecologic cancer patients, the multidisciplinary HIPEC team, comprised of surgical oncologists, medical oncologists, intensivists, chemotherapy nurses and perfusionists at UH Case Medical Center, is offering the procedure to patients with gastrointestinal cancers and mesothelioma.

"We believe this procedure can improve the odds for our patients and are eager to launch this series of clinical trials to further validate HIPEC's use in our patients," says Dr. DeBernardo. "In our battle against cancer, we keep developing novel methods to outsmart the disease and HIPEC is yet another important tool in our war chest."

More information: A video about UH Case Medical Center's HIPEC program can be viewed at: www.youtube.com/watch?v=kDtc2PKP1wc

Provided by University Hospitals Case Medical Center

not rated yet
add to favorites email to friend print save as pdf

Related Stories

Colon cancer 'chemobath' evaluated

Jun 10, 2011

(Medical Xpress) -- As part of a multicenter clinical trial, surgical oncologists at UC San Diego Moores Cancer Center are comparing the effectiveness of standard chemotherapy to a tri-modality approach to halt advanced colon ...

Breakthrough vaccine to treat chemo-resistant ovarian cancer

Mar 08, 2007

Cancer Treatment Centers of America announced today its plans to launch a new cancer vaccine therapy that expands treatment options for thousands of women with advanced stage ovarian cancer. This innovative treatment will ...

Recommended for you

Bone loss drugs may help prevent endometrial cancer

2 hours ago

A new analysis suggests that women who use bisphosphonates—medications commonly used to treat osteoporosis and other bone conditions—have about half the risk of developing endometrial cancer as women who do not use the ...

Putting the brakes on cancer

Dec 19, 2014

A study led by the University of Dundee, in collaboration with researchers at our University, has uncovered an important role played by a tumour suppressor gene, helping scientists to better understand how ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.