University of Kentucky offers stroke stem cell trial

The University of Kentucky will be the first site in the state and one of a select few in the entire country participating in the first stages of a groundbreaking study to investigate the effects of MultiStem, a human adult stem cell product, on patients with acute ischemic stroke. The phase II clinical trial, known as Atherys stroke protocol B01-02, was recently approved by UK's institutional review board.

" may have great potential in stroke treatment, and we need to approach it scientifically. We are excited to be the first to bring a clinical trial of stem cells for stroke to Kentucky," said Dr. Michael Dobbs, director of the UK HealthCare Stroke Affiliate Network and principal investigator on the stem cell trial.

Despite recent advances in interventional ischemic stroke treatment, medical therapy for the treatment of stroke has largely been limited to tPA, the clot-busting drug that received FDA approval in 1996.

Using stem cells in the treatment of stroke represents a novel approach to treating the damage caused by stroke. Studies of animal models suggest that stem cell therapy may offer a unique neuro-protective effect, and further investigation as to the mechanism of this benefit is currently underway.

MultiStem is also being studied as a potential treatment for a variety of diseases, with the therapy already successfully completing a Phase I trial in patients suffering from Graft Versus Host Disease (GVHD), a potentially deadly complication of in cancer patients.

"UK's selection as one of the first sites for this study exemplifies our position as a national leader in cutting edge and research. By pioneering new approaches to , we are doing our part to ensure that our stroke patients receive the absolute best care possible," Dobbs said.

Provided by University of Kentucky

not rated yet
add to favorites email to friend print save as pdf

Related Stories

Bone marrow stem cell therapy safe for acute stroke: report

Aug 31, 2011

Using a patient's own bone marrow stem cells to treat acute stroke is feasible and safe, according to the results of a ground-breaking Phase I trial at The University of Texas Health Science Center at Houston (UTHealth).

Recommended for you

Growing a blood vessel in a week

Oct 24, 2014

The technology for creating new tissues from stem cells has taken a giant leap forward. Three tablespoons of blood are all that is needed to grow a brand new blood vessel in just seven days. This is shown ...

Testing time for stem cells

Oct 24, 2014

DefiniGEN is one of the first commercial opportunities to arise from Cambridge's expertise in stem cell research. Here, we look at some of the fundamental research that enables it to supply liver and pancreatic ...

Team finds key signaling pathway in cause of preeclampsia

Oct 23, 2014

A team of researchers led by a Wayne State University School of Medicine associate professor of obstetrics and gynecology has published findings that provide novel insight into the cause of preeclampsia, the leading cause ...

Rapid test to diagnose severe sepsis

Oct 23, 2014

A new test, developed by University of British Columbia researchers, could help physicians predict within an hour if a patient will develop severe sepsis so they can begin treatment immediately.

User comments