Combo of diabetes, depression increases post-MI mortality

February 27, 2012
Combo of diabetes, depression increases post-MI mortality

(HealthDay) -- Having both diabetes and depression significantly increases the risk of dying in the years following a heart attack, beyond the increased risk from either condition alone, according to a study published in the March issue of Diabetes Care.

Mariska Bot, from Tilburg University in the Netherlands, and colleagues analyzed data from two multicenter cohort studies, including 2,704 patients who were hospitalized for . Diabetes and depression (defined as a score ≥10) were evaluated during hospitalization. Mortality data were available for 2,525 patients, who were followed for an average of 6.2 years.

The researchers found that, during follow-up, 439 patients died. The mortality rate was 14 percent for patients without diabetes and depression, and was 23, 22, and 47 percent for those with diabetes only, depression only, and both diabetes and depression, respectively. After adjusting for other variables, the hazard ratios for all-cause mortality were 1.38 for patients with diabetes only, 1.39 for those with depression only, and 2.90 for patients with both diabetes and depression.

"We observed an increased mortality risk in post-myocardial infarction patients with both diabetes and depression, beyond the association with mortality of diabetes and depression alone," the authors write.

One of the multicenter cohort studies was funded by the pharmaceutical industry.

Explore further: With diabetes, untreated depression can lead to serious eye disease

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Recommended for you

Drug prevents type 1 diabetes in mice, study finds

September 14, 2015

The buildup of a substance in the pancreas during the pre-symptomatic stage of Type 1 diabetes is essential to the development of the disease, Stanford University School of Medicine researchers have shown.

Bacteria may cause type 2 diabetes

June 1, 2015

Bacteria and viruses have an obvious role in causing infectious diseases, but microbes have also been identified as the surprising cause of other illnesses, including cervical cancer (Human papilloma virus) and stomach ulcers ...

Engineered hot fat implants reduce weight gain in mice

August 20, 2015

Scientists at the University of California, Berkeley, have developed a novel way to engineer the growth and expansion of energy-burning "good" fat, and then found that this fat helped reduce weight gain and lower blood glucose ...


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.