Model predicts death due to acetaminophen overdose

Model predicts death due to acetaminophen overdose
Model for Acetaminophen-induced Liver Damage, a mathematical model that utilizes commonly obtained laboratory values, including overdose amount and time elapsed since overdose, is effective for predicting outcomes in patients with acute liver failure due to acetaminophen overdose, according to research published online Feb. 13 in Hepatology.

(HealthDay) -- Model for Acetaminophen-induced Liver Damage (MALD), a mathematical model that utilizes commonly obtained laboratory values, including overdose amount and time elapsed since overdose, is effective for predicting outcomes in patients with acute liver failure due to acetaminophen overdose, according to research published online Feb. 13 in Hepatology.

Christopher H. Remien, of the University of Utah in Salt Lake City, and colleagues developed MALD to describe acute due to an overdose of acetaminophen. The model utilizes laboratory values that are commonly obtained on admission, specifically aspartate aminotransferase (AST), alanine aminotransferase (ALT), and international normalized ratio (INR), to estimate the overdose amount, time elapsed, and outcome. The model was tested on 53 patients.

The researchers found that, using only initial ALT, AST, and INR measurements, the model was able to accurately predict follow-up laboratory values for most patients. With the addition of , the researchers were able to predict eventual death due to acetaminophen overdose with 100 percent sensitivity, 91 percent specificity, 67 percent , and 100 percent negative predictive value.

"Our dynamic model yields a prediction of outcome by estimating the time since overdose and overdose amount from commonly obtained laboratory data on admission," the authors write. "Our initial analysis suggests that MALD compares favorably to statistical methods, and should be validated in multicentric retrospective and prospective evaluation."

More information: Abstract
Full Text (subscription or payment may be required)

Copyright © 2012 HealthDay. All rights reserved.

Citation: Model predicts death due to acetaminophen overdose (2012, February 24) retrieved 28 March 2024 from https://medicalxpress.com/news/2012-02-death-due-acetaminophen-overdose.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Explore further

Unique pattern of gene expression can indicate acetaminophen overdose

 shares

Feedback to editors