Model predicts death due to acetaminophen overdose

Model predicts death due to acetaminophen overdose
Model for Acetaminophen-induced Liver Damage, a mathematical model that utilizes commonly obtained laboratory values, including overdose amount and time elapsed since overdose, is effective for predicting outcomes in patients with acute liver failure due to acetaminophen overdose, according to research published online Feb. 13 in Hepatology.

(HealthDay) -- Model for Acetaminophen-induced Liver Damage (MALD), a mathematical model that utilizes commonly obtained laboratory values, including overdose amount and time elapsed since overdose, is effective for predicting outcomes in patients with acute liver failure due to acetaminophen overdose, according to research published online Feb. 13 in Hepatology.

Christopher H. Remien, of the University of Utah in Salt Lake City, and colleagues developed MALD to describe acute due to an overdose of acetaminophen. The model utilizes laboratory values that are commonly obtained on admission, specifically aspartate aminotransferase (AST), alanine aminotransferase (ALT), and international normalized ratio (INR), to estimate the overdose amount, time elapsed, and outcome. The model was tested on 53 patients.

The researchers found that, using only initial ALT, AST, and INR measurements, the model was able to accurately predict follow-up laboratory values for most patients. With the addition of , the researchers were able to predict eventual death due to acetaminophen overdose with 100 percent sensitivity, 91 percent specificity, 67 percent , and 100 percent negative predictive value.

"Our dynamic model yields a prediction of outcome by estimating the time since overdose and overdose amount from commonly obtained laboratory data on admission," the authors write. "Our initial analysis suggests that MALD compares favorably to statistical methods, and should be validated in multicentric retrospective and prospective evaluation."

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Better labeling could help thwart acetaminophen overdose

date May 03, 2011

While well known for relieving everyday aches and pains, few realize that when misused, acetaminophen can lead to acute liver failure and even death, often due to accidental overdose by an uninformed consumer. A new small ...

Recommended for you

Rapamune approved for rare lung disease

date 16 hours ago

(HealthDay)—Rapamune (sirolimus) has been approved by the U.S. Food and Drug Administration to treat a rare, progressive lung disease that mostly affects women of childbearing age.

FDA warns of complications from facial fillers

date 16 hours ago

(HealthDay)—Soft tissue fillers used in cosmetic procedures can accidentally be injected into blood vessels in the face and cause serious harm, the U.S. Food and Drug Administration warns.

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.