Heartburn controlled with step down to once daily therapy

Heartburn controlled with step down to once daily therapy

(HealthDay) -- The majority of gastroesophageal reflux disease (GERD) patients who take twice-daily proton pump inhibitor (PPI) therapy, are able to successfully step down to management of heartburn with a daily dose of dexlansoprazole modified release (MR), according to a study published in the March issue of Clinical Gastroenterology and Hepatology.

Ronnie Fass, M.D., of the Southern Arizona VA Healthcare System in Tucson, and associates conducted a multicenter, single-blind study of 142 patients with GERD to determine if twice-daily PPI therapy for more than eight weeks could be phased down successfully to 30 mg once-daily dexlansoprazole MR and what the impact would be on health-related quality of life (QOL). Patients recorded heartburn in electronic diaries; heartburn was considered well-controlled if patients had an average of one symptom or fewer per week during the last four weeks of treatment. GERD-related symptoms and QOL were assessed using the Patient Assessment of Upper (PAGI) Symptom Severity Index and the PAGI-QOL, respectively.

The researchers found that, following step down from PPI therapy, heartburn remained well controlled in 125 patients (88 percent), and these patients were able to maintain their QOL and GERD-related symptom severity.

"Step-down management of GERD patients who have obtained heartburn symptom control on twice-daily dosing should be considered to reduce costs, possibly improve compliance, and reduce the risk of side effects associated with high-dose PPI use," the authors write.

Several authors disclosed financial ties to pharmaceutical and medical device companies, including Takeda, which funded the study and manufactures dexlansoprazole.

More information: Abstract
Full Text (subscription or payment may be required)
Editorial

add to favorites email to friend print save as pdf

Related Stories

Natural history of heartburn

Feb 07, 2011

A research team from Iceland studied the natural history and prevalence of heartburn at a 10-year interval, and the effect of heartburn on various symptoms and activities. The results showed that heartburn is a common and ...

Acid-reducing medicines may lead to dependency

Jul 01, 2009

Treatment with proton pump inhibitors (PPIs) for eight weeks induces acid-related symptoms like heartburn, acid regurgitation and dyspepsia once treatment is withdrawn in healthy individuals, according to a new study in Gastroenterology, th ...

Recommended for you

Evidence-based recs issued for systemic care in psoriasis

9 hours ago

(HealthDay)—For appropriately selected patients with psoriasis, combining biologics with other systemic treatments, including phototherapy, oral medications, or other biologic, may result in greater efficacy ...

Bacteria in caramel apples kills at least four in US

9 hours ago

A listeria outbreak believed to originate from commercially packaged caramel apples has killed at least four people in the United States and sickened 28 people since November, officials said Friday.

Steroid-based treatment may answer needs of pediatric EoE patients

9 hours ago

A new formulation of oral budesonide suspension, a steroid-based treatment, is safe and effective in treating pediatric patients with eosinophilic esophagitis (EoE), according to a new study in Clinical Gastroenterology and Hepatology, the official clinical practice journal ...

Discovery of genes that predispose a severe form of COPD

12 hours ago

A study by Ramcés Falfán-Valencia, researcher at the National Institute of Respiratory Diseases (INER), found that the mestizo Mexican population has a number of variations in certain genes that predispose ...

On the environmental trail of food pathogens

13 hours ago

Tracking one of the deadliest food contamination organisms through produce farms and natural environments alike, Cornell microbiologists are showing how to use big datasets to predict where the next outbreak could start.

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.