Researchers study mitochondrial function, potential new therapeutic target for Alzheimer's disease
Researchers at Rush University Medical Center are conducting an early phase clinical trial of a novel drug therapy for patients with dementia due to Alzheimer's disease. The drug is a new compound called MSDC-0160, which is an insulin sensitizer that modulates mitochondrial metabolism.
Mitochondria are known as the powerhouses of cells, including brain cells. Mitochondria help convert glucose, which is thought to be the main fuel source for brain cells, into energy.
Mitochondrial function may play an important role in brain cell survival. Reduced mitochondrial function in converting glucose into energy seems to occur early in Alzheimer's disease.
"In this initial study, we are trying to determine if MSDC-0160 improves the brain's use of glucose," said Dr. Raj C. Shah, director of the Rush Memory Clinic at the Rush Alzheimer's Disease Center and principal investigator of the study. "We can measure brain cell glucose use using fluordeoxyglucose positron-emission tomography (FDG-PET), a special brain imaging test."
MSDC-0160 also is being developed as a treatment for diabetes by Metabolic Solutions Development Company, a Kalamazoo, Michigan-based developer of new therapeutics to treat metabolic diseases associated with age-related mitochondrial dysfunction.
An earlier mouse model study indicated that MSDC-0160 may reduce Alzheimer's like pathology in mouse brains.
As a result of this finding, Rush is conducting a Phase IIa trial that will help determine if the drug therapy affects glucose utilization in specific regions of the brain. Rush is the only medical center in the U.S. conducting the double-blind, placebo-controlled study.
Patients who are 55-85 years of age, who do not have diabetes, and who have been diagnosed with mild dementia due to Alzheimer's disease are being enrolled in the clinical trial. Forty patients in the study will be randomized to receive either MSDC-0160 or a placebo once daily for 90 days.
The study was awarded a grant by the Alzheimer's Drug Discovery Foundation (ADDF). The mouse model study was conducted by Doug Feinstein, PhD, at the University of Illinois at Chicago.
Provided by Rush University Medical Center
- Indications of Alzheimer's disease may be evident decades before first signs of cognitive impairment Mar 28, 2011 | not rated yet | 0
- UCLA imaging study suggests Alzheimer's drug may help mild memory loss Jul 30, 2008 | not rated yet | 0
- Mitochondria could be a target for therapeutic strategy for Alzheimer's disease patients Nov 05, 2008 | not rated yet | 0
- New target identified for Alzheimer’s disease Sep 29, 2010 | not rated yet | 0
- Early role of mitochondria in AD may help explain limitations to current beta amyloid hypothesis Oct 13, 2010 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
The idea behind a reverse shock
30 minutes ago So in a supernova explosion for example (5th slide) http://www.astro.princeton.edu/~burrows/classes/541/blastwavesChisari.pdf Ambient medium is...
Guass's Law for a charge distribution
43 minutes ago First, this is not a homework question, just something I've been confused about for some time. I understand how to use Guass's law in many ways but...
1 hour ago Hello :) i'm new to this forum, so excuse me for my straightforwardness ;) I'm working on my bachelor work and i can't find a solution. I'm writing...
siphon and bernouli theorum
3 hours ago 1. I found this diagram on book but there weren't any description.can someone tell me, what its trying to tell specially by those two red lines...
Hot gas expansion rate into outer space
3 hours ago Good Morning Sirs, it seems to be surprisingly hard to get the numbers of a mystery: How fast expand hot rocket exhaust gases into empty space? ...
Magnetic field lines through copper
8 hours ago Hello. Assume an electron gun, as in CRT, made of plumbing copper instead of glass. Using magnetic scanning coils to move electron beam. Will the...
- More from Physics Forums - Classical Physics
More news stories
In the search for medication against Alzheimer's disease, scientists have focused – among other factors – on drugs that can break down Amyloid beta (A-beta). After all, it is the accumulation of A-beta that causes the ...
Alzheimer's disease & dementia May 24, 2013 | not rated yet | 0
(Medical Xpress)—The way Alzheimer's disease is portrayed by advocacy groups and the media is having undue influence on the euthanasia debate, according to a Deakin University nursing ethics professor.
Alzheimer's disease & dementia May 24, 2013 | not rated yet | 2
Cinnamon: Can the red-brown spice with the unmistakable fragrance and variety of uses offer an important benefit? The common baking spice might hold the key to delaying the onset of –– or warding off ...
Alzheimer's disease & dementia May 23, 2013 | 5 / 5 (5) | 0 |
An anti-cancer drug reverses memory deficits in an Alzheimer's disease mouse model, University of Pittsburgh Graduate School of Public Health researchers confirm in the journal Science.
Alzheimer's disease & dementia May 23, 2013 | not rated yet | 0 |
Teams of highly respected Alzheimer's researchers failed to replicate what appeared to be breakthrough results for the treatment of this brain disease when they were published last year in the journal Science.
Alzheimer's disease & dementia May 23, 2013 | 3 / 5 (2) | 3 |
Coenzyme Q10 decreases all cause mortality by half, according to the results of a multicentre randomised double blind trial presented today at Heart Failure 2013 congress. It is the first drug to improve heart failure mortality ...
6 hours ago | 5 / 5 (2) | 4
Heart failure accelerates the aging process and brings on early andropausal syndrome (AS), according to research presented today at the Heart Failure Congress 2013. AS, also referred to as male 'menopause', was four times ...
6 hours ago | not rated yet | 1
Mortality and length of stay are highest in heart failure patients admitted in January, on Friday, and overnight, according to research presented today at the Heart Failure Congress 2013. The analysis of nearly 1 million ...
6 hours ago | not rated yet | 0
(AP)—Department of Justice lawyers have again asked a federal appeals court in New York to delay lifting age restrictions and prescription requirements on an emergency contraceptive popularly known as the morning-after ...
6 hours ago | not rated yet | 0
Two mutations central to the development of infantile myofibromatosis (IM)—a disorder characterized by multiple tumors involving the skin, bone, and soft tissue—may provide new therapeutic targets, according to researchers ...
22 hours ago | 3 / 5 (2) | 0 |
Talking on a hands-free device while behind the wheel can lead to a sharp increase in errors that could imperil other drivers on the road, according to new research from the University of Alberta.
22 hours ago | not rated yet | 0