X-Chromosome gene variant linked to SIDS in boys

February 21, 2012 by HealthDay reporters
X-Chromosome gene variant linked to SIDS in boys
A gene variant on the X-chromosome is associated with sudden infant death syndrome (SIDS) only in boys, particularly those who die at the ages of highest SIDS prevalence, according to a study published online Feb. 20 in Pediatrics.

(HealthDay) -- A gene variant on the X-chromosome is associated with sudden infant death syndrome (SIDS) only in boys, particularly those who die at the ages of highest SIDS prevalence, according to a study published online Feb. 20 in Pediatrics.

Noting that the X-chromosomal A (MAOA) gene is important in both the serotonergic and noradrenergic neuronal systems, Michael Klintschar, M.D., from Medical University Hannover, and Christian Heimbold, from Georg August University Göttingen -- both in Germany, examined the frequency of functional polymorphism in the promoter of the MAOA gene in 156 white SIDS cases and 260 gender- and age-matched controls.

The researchers found that the pooled low-expressing alleles *2 and *3 were present in 44.4 percent of male SIDS cases but only 25.5 percent of male control cases. In contrast, there were no differences for females. These alleles were more frequent in infants who died at ages of 46 to 154 days than those who died at an older age (54.9 versus 22.6 percent).

"Our results indicate a relationship between SIDS and the MAOA genotype in boys via influencing serotonergic and noradrenergic neurons in the brainstem," the authors conclude. "This locus is the first X-chromosomal locus associated with SIDS."

Explore further: SIDS link: Low blood pressure in preterm infants

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

SIDS link: Low blood pressure in preterm infants

December 8, 2008

Scientists from Monash University, Melbourne have shown that infants born prematurely have lower blood pressure during sleep in the first six months of life, compared to healthy, full-term infants.

Was SIDS the cause of infant deaths even 150 years ago?

July 14, 2009

Nineteenth century infant deaths attributed to smothering and overlaying, by either a co-sleeper or bedding, were in all likelihood crib deaths, or Sudden Infant Death Syndrome (SIDS). These deaths would have been mislabeled ...

Sudden infant death syndrome spikes on New Year's Day

December 15, 2010

Not a happy holiday thought, but an important one: The number of babies who die of SIDS, or sudden infant death syndrome, surges by 33 percent on New Year's Day. The suspected reason? Alcohol consumption by caretakers the ...

Lower risk of SIDS linked to breastfeeding

June 14, 2011

(Medical Xpress) -- In a new study published in Pediatrics, lead researcher Dr. Fern Hauck from the University School of Medicine analyzed previous sudden infant death syndrome, or SIDS, studies and agrees that breastfeeding ...

Recommended for you

Solving the mystery of meningiomas reveals a surprise twist

August 23, 2016

In solving one mystery—the genetic roots of benign brain tumors called meningiomas—a team of scientists led by Yale researchers stumbled upon an even greater one: How is it possible that two of the mutations linked to ...

Two key proteins preserve vital genetic information

August 22, 2016

Cancer is often driven by various genetic mutations that are acquired through changes to a person's DNA over time. These alterations can occur at the chromosome level if the proteins are not properly organized and segregated ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.