X-Chromosome gene variant linked to SIDS in boys

by HealthDay reporters
X-Chromosome gene variant linked to SIDS in boys
A gene variant on the X-chromosome is associated with sudden infant death syndrome (SIDS) only in boys, particularly those who die at the ages of highest SIDS prevalence, according to a study published online Feb. 20 in Pediatrics.

(HealthDay) -- A gene variant on the X-chromosome is associated with sudden infant death syndrome (SIDS) only in boys, particularly those who die at the ages of highest SIDS prevalence, according to a study published online Feb. 20 in Pediatrics.

Noting that the X-chromosomal A (MAOA) gene is important in both the serotonergic and noradrenergic neuronal systems, Michael Klintschar, M.D., from Medical University Hannover, and Christian Heimbold, from Georg August University Göttingen -- both in Germany, examined the frequency of functional polymorphism in the promoter of the MAOA gene in 156 white SIDS cases and 260 gender- and age-matched controls.

The researchers found that the pooled low-expressing alleles *2 and *3 were present in 44.4 percent of male SIDS cases but only 25.5 percent of male control cases. In contrast, there were no differences for females. These alleles were more frequent in infants who died at ages of 46 to 154 days than those who died at an older age (54.9 versus 22.6 percent).

"Our results indicate a relationship between SIDS and the MAOA genotype in boys via influencing serotonergic and noradrenergic neurons in the brainstem," the authors conclude. "This locus is the first X-chromosomal locus associated with SIDS."

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Lower risk of SIDS linked to breastfeeding

Jun 14, 2011

(Medical Xpress) -- In a new study published in Pediatrics, lead researcher Dr. Fern Hauck from the University School of Medicine analyzed previous sudden infant death syndrome, or SIDS, studies and agrees ...

SIDS link: Low blood pressure in preterm infants

Dec 08, 2008

Scientists from Monash University, Melbourne have shown that infants born prematurely have lower blood pressure during sleep in the first six months of life, compared to healthy, full-term infants.

Was SIDS the cause of infant deaths even 150 years ago?

Jul 14, 2009

Nineteenth century infant deaths attributed to smothering and overlaying, by either a co-sleeper or bedding, were in all likelihood crib deaths, or Sudden Infant Death Syndrome (SIDS). These deaths would have been mislabeled ...

Recommended for you

Refining the language for chromosomes

Apr 17, 2014

When talking about genetic abnormalities at the DNA level that occur when chromosomes swap, delete or add parts, there is an evolving communication gap both in the science and medical worlds, leading to inconsistencies in ...

Down's chromosome cause genome-wide disruption

Apr 16, 2014

The extra copy of Chromosome 21 that causes Down's syndrome throws a spanner into the workings of all the other chromosomes as well, said a study published Wednesday that surprised its authors.

User comments