Activities, smoking affect lymph node involvement in melanoma

Activities, smoking affect lymph node involvement in melanoma

(HealthDay) -- Several factors, including sporting activity, physical workload, and smoking habits, affect the sonomorphologic characteristics of peripheral lymph nodes (LNs) in patients with a history of invasive cutaneous melanoma, according to research published online Feb. 29 in the Journal of the American Academy of Dermatology.

Torsten Hinz, M.D., of the University of Bonn in Germany, and colleagues conducted a prospective study involving 200 consecutive patients with a history of invasive cutaneous melanoma. They sought to determine what influence, if any, a patient's sporting activity, physical workload, interferon alfa therapy, smoking habits, and upper may have on the number and morphology of peripheral LNs, as examined using high-resolution ultrasound of the cervical, , and inguinal lymph node regions.

The researchers found that, compared with non-active patients, patients with a history of invasive cutaneous melanoma who were highly active in sports tended to have a higher number of LNs in the inguinal region, a higher volume and larger LN diameter, and a higher maximum width of the hypoechoic LN margin. Those whose occupation included heavy physical workloads had a significantly larger volume of the biggest LNs. Smokers also tended to have more LNs, more large-volume LNs, and the largest diameter of LNs in the cervical regions, when compared with nonsmokers.

"Although these influencing factors and their associated mechanisms of action are not fully understood so far, they should always be considered when performing ultrasound examinations of the peripheral LNs in patients with cutaneous melanoma," the authors write.

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Larger skin lesions appear more likely to be melanomas

Apr 21, 2008

Skin lesions larger than 6 millimeters in diameter appear more likely to be melanomas than smaller lesions, according to a report in the April issue of Archives of Dermatology. The findings suggest that the diameter guidel ...

Recommended for you

Study shows epigenetic changes can drive cancer

Jul 26, 2014

Cancer has long been thought to be primarily a genetic disease, but in recent decades scientists have come to believe that epigenetic changes – which don't change the DNA sequence but how it is 'read' – also play a role ...

User comments