Bevacizumab doesn't up overall survival in prostate cancer

To evaluate the efficacy of DP treatment with and without B, William Kevin Kelly, D.O., of Thomas Jefferson University in Philadelphia, and colleagues conducted a phase 3, randomized, placebo-controlled trial involving 1,050 men with chemotherapy-naive progressive mCRPC. OS was the primary end point, and secondary end points included PFS, OR, and toxicity.

The researchers observed no significant difference in median OS between patients receiving DP+B and DP (22.6 and 21.5 months, respectively; stratified log-rank P = 0.181). Men treated with DP+B had significantly longer median PFS compared with those receiving DP alone (9.9 versus 7.5 months; stratified log-rank P < 0.001). The proportion of patients with OR was significantly superior in the DP+B group versus DP alone (49.4 versus 35.5 percent; P = 0.0013). Treatment-related deaths (4.0 versus 1.2 percent; P = 0.005) and the percentage of men experiencing grade 3 or higher treatment-related toxicity (75.4 versus 56.2 percent; P ≤ 0.001) were significantly higher for those receiving DP+B.

"Despite an improvement in PFS and OR, the addition of bevacizumab to docetaxel and prednisone did not improve OS in men with mCRPC and was associated with greater toxicity," the authors write.

The authors disclosed financial relationships with pharmaceutical companies, including Genentech, which together with Roche funded the study.

More information: Abstract
Full Text (subscription or payment may be required)

Journal reference: Journal of Clinical Oncology

Copyright © 2012 HealthDay. All rights reserved.