New research sheds light on cancer of the appendix

March 7, 2012

Researchers at Wake Forest Baptist Medical Center have demonstrated that cancer of the appendix is different than colon cancer, a distinction that could lead to more effective treatments for both diseases.

The study by Edward A. Levine, M.D., professor of surgery and chief of the surgical oncology service at Wake Forest Baptist, is the result of gene analysis of cases covering a 10-year period. It appears in the early online edition of the April issue of the .

Cancer of the appendix, which is part of the colon, affects approximately 2,500 people in the United States annually and has the propensity to spread throughout the peritoneal cavity, the space within the abdomen that contains the intestines, stomach and liver.

"Our treatment program, which was the catalyst for this research, is one of the largest worldwide and consists of aggressive surgery coupled with heated chemotherapy placed directly into the at the time of surgery," Levine said. "Given the uncertainty of predicting outcomes in patients with disseminated appendiceal cancer, we sought to use the tools of to better understand these rare malignancies at a molecular level in order to better predict oncologic outcomes. We've looked at the genes that make these cancers tick, and we actually started to pick them apart for the first time."

For the study, the researchers examined tumor samples from Wake Forest Baptist's for patterns of expression of different genes.

"By looking at these genetic signatures, we found that the genes active in cancer of the colon and those active in cancer of the appendix are very different," Levine said. "For years, however, cancer of the appendix, which is part of the colon, has been treated with the same used for . This study shows that we need a fresh approach to how we treat appendix cancer."

Related Stories

Recommended for you

Scientists developing new test for breast cancer

September 29, 2016

Scientists at The Australian National University (ANU) are working with researchers in France to develop a new potential way to detect and monitor breast cancer that could involve a simple blood test.

Tumor paint brings light to toddler's brain tumor

September 28, 2016

In December of last year, Laura Coffman began to notice that something wasn't quite right with her 2-year-old son, Hunter. He was leaning to one side and seemed to lose his balance easily. When he became lethargic and started ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.