Circulating endothelial cells potential biomarker for myocardial infarction
(HealthDay) -- Circulating endothelial cell (CEC) counts are elevated among patients with myocardial infarction (MI), and the cells have distinct morphological features, according to a study published in the March 21 issue of Science Translational Medicine.
Samir Damani, M.D., Pharm.D., from the Scripps Translational Science Institute in La Jolla, Calif., and colleagues used an automated and clinically feasible CEC three-channel fluorescence microscope assay to characterize CECs in 50 consecutive patients with ST-segment elevation MI and 44 healthy controls.
The researchers found that, in MI cases, CEC counts were significantly elevated, with a median number of 19 cells/mL versus 4 cells/mL in healthy controls. The area under the receiver-operating characteristic curve was 0.95, indicating near-dichotomization of MI cases versus controls. No correlation was seen between CECs and typical markers of myocardial necrosis. Compared with normal CECs and CECs from patients with peripheral vascular disease, CECs from MI patients had a 2.5-fold increase in cellular area and a two-fold increase in nuclear area seen on morphological analysis of microscopy images. Patients with MI were the only subject group that had CECs with more than three nuclei per image.
"We show that there is a clear excess of CECs and that these cells have discrete antigenic and morphological signatures. These distinctive cell characteristics may be useful in developing a refined biomarker for arterial injury," the authors write. "Our findings may ultimately support the development of an assay to help predict imminent risk of a heart attack."
One of the study authors is listed as an author on a patent associated with this work.
More information: Abstract
Full Text (subscription or payment may be required)
Journal reference:
Science Translational Medicine
Copyright © 2012 HealthDay. All rights reserved.
-
More sensitive blood test better at identifying heart attacks
Mar 22, 2011 |
not rated yet |
0
-
Stroke incidence higher among patients with certain type of retinal vascular disease
Mar 14, 2011 |
not rated yet |
0
-
Tests for biomarker may help determine diagnosis of heart attack within hours
Dec 27, 2011 |
not rated yet |
0
-
Study shows emergency physicians have good first instincts in diagnosing heart attacks
Jul 24, 2008 |
not rated yet |
0
-
Risk of heart attack in patients
Jun 18, 2010 |
not rated yet |
0
-
Motion perception revisited: High Phi effect challenges established motion perception assumptions
Apr 23, 2013 |
3 / 5 (2) |
2
-
Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update)
Apr 02, 2013 |
4.5 / 5 (11) |
5
-
The visual system as economist: Neural resource allocation in visual adaptation
Mar 30, 2013 |
5 / 5 (2) |
9
-
Separate lives: Neuronal and organismal lifespans decoupled
Mar 27, 2013 |
4.9 / 5 (8) |
0
-
Sizing things up: The evolutionary neurobiology of scale invariance
Feb 28, 2013 |
4.8 / 5 (10) |
14
-
Calculating on-axis elements of a solenoid
9 hours ago
-
latitude & longitude & air pressure
10 hours ago
-
Differences of Classical Mechanics when learned with Calc vs algebra?
13 hours ago
-
what is the distance traveled
17 hours ago
-
Image of a Convex Lens Cut in Half Horizontally
21 hours ago
-
Ray tracing through optical system of thick lenses
21 hours ago
- More from Physics Forums - Classical Physics
More news stories
Costs to treat stroke in America may double by 2030
Costs to treat stroke are projected to more than double and the number of people having strokes may increase 20 percent by 2030, according to the American Heart Association/American Stroke Association.
Cardiology
18 hours ago |
not rated yet |
0
New blood-thinner measures may cut medication errors
Blood thinners are the preferred treatment option to prevent heart attacks, blood clots and stroke, but they are not without risk, and not just because of their side effects. These high-risk drugs, known as anticoagulants, ...
Cardiology
21 hours ago |
not rated yet |
0
Registry questions superiority of bivalirudin over heparin
Results from a large observational study reported at EuroPCR 2013 today question whether bivalirudin is superior to heparin in the absence of GPIIb/IIIa blockade, showing similar 30-day mortality in patients with non-ST segment ...
Cardiology
21 hours ago |
not rated yet |
0
Study shows low rate of late lumen loss with bioresorbable DESolve device
The DESolve bioresorbable coronary scaffold system achieves good efficacy and safety with low rates of late lumen loss and major coronary adverse events at six months, show first results from the pivotal DESolve Nx trial ...
Cardiology
21 hours ago |
not rated yet |
0
Biodegradable stent proves non-inferior to drug-eluting stent
The Orsiro stent, which is a novel stent platform eluting sirolimus from a biodegradable polymer, demonstrated non-inferiority to the Xience Prime everolimus-eluting stent for the primary angiographic endpoint of in-stent ...
Cardiology
May 21, 2013 |
5 / 5 (1) |
0
US teen birth rate drops to record low
US teen births have dropped to a record low, but the country still has one of the highest rates among developed nations, the US Centers for Disease Control and Prevention said Thursday.
Slowing the aging process—only with antibiotics
Swiss scientists reveal the mechanism responsible for aging hidden deep within mitochondria—and dramatically slow it down in worms by administering antibiotics to the young.
Researchers complete largest genetic sequencing study of human disease
Researchers from Queen Mary, University of London have led the largest sequencing study of human disease to date, investigating the genetic basis of six autoimmune diseases.
Brain can be trained in compassion, study shows
Until now, little was scientifically known about the human potential to cultivate compassion—the emotional state of caring for people who are suffering in a way that motivates altruistic behavior.
Rate of bicycle-related fatalities significantly lower in states with helmet laws
Existing research shows that bicyclists who wear helmets have an 88 percent lower risk of brain injury, but researchers at Boston Children's Hospital found that simply having bicycle helmet laws in place showed a 20 percent ...
Having both migraines, depression may mean smaller brain
(HealthDay)—Migraines and depression can each cause a great deal of suffering, but new research indicates the combination of the two may be linked to something else entirely—a smaller brain.