Clinical trial to test success of Cystic Fibrosis lung infection treatment
Experts from Bristol and Nottingham are leading a major new national study to investigate whether intravenous antibiotics are effective in killing a common germ that causes dangerous complications in cystic fibrosis (CF) patients.
The team is hoping to find out if the treatment is more effective than traditional therapies in tackling Pseudomonas aeruginosa, which causes a chronic destructive lung infection in CF patients and which cannot be eradicated unless it is caught in the early stages.
Dr Simon Langton Hewer, from University Hospitals Bristol NHS Foundation Trust, who is chief investigator of the study, said: "It's very exciting to have a clinical trial available to CF patients around the whole of the UK. This is the first CF trial for many years to be run in the UK and will answer one of the important questions affecting CF patients."
Professor Alan Smyth in The University of Nottingham's School of Clinical Sciences, a co-investigator in the TORPEDO clinical trial, said: "Children and adults with CF are now receiving intravenous antibiotics for Pseudomonas more and more often, with no good evidence that this is more effective. We want to see if intravenous antibiotics do work better than traditional oral treatment because oral treatment is easier to give at home and does not require a hospital admission."
Pseudomonas aeruginosa is a bacterium that lives in the environment, lurking in places such as sink drains. Most CF patients have chronic lung infection with the germ by their late teens. Oral and nebulised (inhaled) antibiotics have mainly been used to eradicate Pseudomonas, but are often only effective if the infection is caught in time.
Intravenous antibiotics are being used more often to treat the infection, however, there is no current clear scientific evidence that intravenous treatment is better than oral treatments. Intravenous treatment means that patients with CF need to spend up to two weeks in hospital in addition to the medication they may previously have been prescribed.
The new trial is funded with £1.5 million from the National Institute for Health Research (NIHR) Health Technology Assessment (HTA) programme and sponsored by University Hospitals Bristol NHS Foundation Trust. So far, 41 CF centres and clinics around the UK have signed up to the trial coordinated from the Medicines for Children Research Network (MCRN) Clinical Trials Unit in Liverpool with the aim of recruiting 280 volunteer CF patients.
Adele Whitford from Severn Beach near Bristol, whose daughter has cystic fibrosis, said: "We decided to take part in the trial because we want to help improve the care for cystic fibrosis patients. As a nurse, part of my job is to provide best evidence practice and without research being carried out you haven't got that evidence."
Zoë and Steve Elliott, of Mapperley Park, Nottingham, have two-year-old twins Alexander and Isobel who were both diagnosed with CF shortly after they were born. They say they didn't hesitate in getting the twins involved with the trial and hope the research will give parents of children with CF firm evidence of whether IV antibiotics really do offer the best treatment option.
Zoë said: "When we were invited on to the trial I was initially really surprised that this research hadn't already been done because in our experience IV antibiotics are generally perceived among parents of children with CF to be the best way of eradicating the infection. As a mum, if it's a toss-up between being at home with a nebuliser for three months or having your child in hospital having invasive treatment for two weeks I know what my gut instinct tells me it's home every time. But it would be reassuring to have some firm evidence to allow us to make a more informed choice and that's why this research is long overdue."
Matthew Reed, Chief Executive of the Cystic Fibrosis Trust said: "Pseudomonas infection is a leading cause of lung damage in people with CF so it is important to find the most effective way to eradicate this bug and therefore help people with CF to live longer. We commend the team at Nottingham and Bristol for their initiative on this study and hope that suitable people with CF throughout the UK will agree to take part in this important piece of research. It is great to see so many UK CF centres (large and small) involved and we would encourage centres not yet taking part to sign up for the trial."
Patients with a new Pseudomonas aeruginosa infection which has been identified through a routine sample from the lungs are being invited on to the study and are given (at random) either two weeks of intravenous antibiotics and three months of nebulised antibiotics or three months of combined oral and nebulised treatment. They will then be followed up for a further 15 months through routine clinic visits to assess whether the germ has been eradicated and stays away for at least a year.
If the trial finds that intravenous antibiotics are more successful in treating the infection, this will form the basis of national guidelines on standard medical practice and mean that patients have access to a more effective treatment.
If intravenous treatment doesn't work as well as traditional methods, it could spare patients the inconvenience of hospitalisation, the trauma of having an intravenous cannula inserted a particular problem for many children suffering from CF and the upset of missing school or work for two weeks.
More information: The trial is open to adults and children with CF (excluding babies under one month old) and further information about the trial and how to participate can be found at www.torpedo-cf.org… k/index.html
Provided by University of Nottingham
- New approach to treating cystic fibrosis lung infection shows promise Sep 22, 2008 | not rated yet | 0
- Use of antibiotic by children with cystic fibrosis does not result in improved lung function May 04, 2010 | not rated yet | 0
- Early cystic fibrosis lung disease detected by bronchoalveolar lavage and lung clearance index Jan 27, 2012 | not rated yet | 0
- Garlic hope in infection fight Jan 31, 2007 | not rated yet | 0
- Bacterial infection alone not an indicator of poor lung function in adolescents with CF May 16, 2011 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
Classical and Quantum Mechanics via Lie algebras
Apr 15, 2011 I'd like to open a discussion thread for version 2 of the draft of my book ''Classical and Quantum Mechanics via Lie algebras'', available online at http://lanl.arxiv.org/abs/0810.1019 , and for the...
- More from Physics Forums - Independent Research
More news stories
There are significant cost and risk factors associated with two procedures commonly used to diagnose or treat gastrointestinal problems, according to research presented at Digestive Disease Week (DDW).
Diseases, Conditions, Syndromes 2 hours ago | not rated yet | 0
Regular consumption of coffee is associated with a reduced risk of primary sclerosing cholangitis (PSC), an autoimmune liver disease, Mayo Clinic research shows. The findings were being presented at the Digestive Disease ...
Diseases, Conditions, Syndromes 3 hours ago | not rated yet | 0 |
A new case of the deadly coronavirus has been detected in Saudi Arabia where 15 people have already died after contracting it, the health ministry announced on Saturday on its Internet website.
Diseases, Conditions, Syndromes 15 hours ago | not rated yet | 0
(HealthDay)—Few randomized clinical trials have been done to assess clinical prediction rules for patients with lower back pain, and the trials that have been done are of low quality and do not provide ...
Diseases, Conditions, Syndromes May 17, 2013 | not rated yet | 0 |
A new, highly sensitive blood test that quickly detects even the lowest levels of malaria parasites in the body could make a dramatic difference in efforts to tackle the disease in the UK and across the world, according to ...
Diseases, Conditions, Syndromes May 17, 2013 | not rated yet | 0
Patients with treatment-resistant major depression saw dramatic improvement in their illness after treatment with ketamine, an anesthetic, according to the largest ketamine clinical trial to-date led by researchers from the ...
3 hours ago | 4.5 / 5 (2) | 0 |
Research presented at Digestive Disease Week (DDW) explores new methods for managing digestive health through diet and lifestyle.
3 hours ago | not rated yet | 0
The use of a smartphone application significantly improves patients' preparation for a colonoscopy, according to new research presented today at Digestive Disease Week (DDW). The preparation process, which begins days in ...
2 hours ago | not rated yet | 0
An increasing number of U.S. children are experiencing gastrointestinal issues that require interventions to resolve, according to research presented at Digestive Disease Week (DDW).
17 hours ago | not rated yet | 0 |
The latest makeover to a massive psychiatric tome honored by some, reviled by others and even called the "Bible" of mental disorders is being released Saturday with a host of new changes.
15 hours ago | not rated yet | 0
A ground-breaking advance in colonoscopy technology signals the future of colorectal care, according to research presented today at Digestive Disease Week(DDW). Additional research focuses on optimizing the minimal withdrawal ...
17 hours ago | 5 / 5 (2) | 0