CYFRA21-1 might be predictive marker in advanced NSCLC

March 15, 2012

Researchers found that CYFRA and change in levels of CYFRA were found to be reliable markers for response to chemotherapy for non-small cell lung cancer (NSCLC) in a study of 88 patients. Research presented in the April 2012 issue of the International Association for the Study of Lung Cancer's (IASLC) Journal of Thoracic Oncology shows that this marker can be used to determine whether or not a patient should continue a particular chemotherapy regimen.

As part of a study performed by the Cancer and Leukemia Group B in advanced lung cancer, serum CYFRA levels were measured at baseline and after the first cycle of treatment. According to the study, "higher baseline CYFRA concentrations portend worse overall and failure free survival. Additionally, this trial confirmed the significance of the cut point of a 27 percent reduction in log CYFRA after chemotherapy is of value in determining benefit from treatment."

Researchers warn that further studies are needed, but "if confirmed, this would provide a simple and inexpensive approach to assessment of response to treatment."

The lead author of this work is IALSC member Dr. Martin Edelman. IASLC member co-authors include Dr. Everett Vokes and Dr. Robert Kratzke.

Explore further: High EGFR expression a predictor for improved survival with cetuximab plus chemotherapy

Related Stories

Recommended for you

Combination therapy can prevent cytostatic resistance

November 26, 2015

Researchers at Karolinska Institutet have found a new way of preventing resistance to cytostatics used in the treatment of cancers such as medulloblastoma, the most common form of malignant brain tumour in children. The promising ...

Forecasting the path of breast cancer in a patient

November 23, 2015

USC researchers have developed a mathematical model to forecast metastatic breast cancer survival rates using techniques usually reserved for weather prediction, financial forecasting and surfing the Web.


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.