Fecal transplant feasible for recurrent <i>C. difficile</i> infection

Fecal transplant feasible for recurrent <i>C. difficile</i> infection

(HealthDay) -- Recurrent Clostridium difficile (C. difficile) infection (CDI) can successfully be treated in the vast majority of patients through a fecal transplantation procedure via colonoscopy, according to research published in the March issue of Gastroenterology.

Eero Mattila, M.D., of the Helsinki University Central Hospital, and colleagues reviewed for 70 patients with recurrent CDI who had undergone a fecal transplantation procedure in which fresh donor feces were infused into the cecum via after whole-bowel lavage with .

The researchers found that, during the first 12 weeks post-transplantation, all patients without infection with strain 027 C. difficile, and 89 percent of the 36 patients infected with the 027 strain, had symptom resolution. All non-responders had a pre-existing serious condition and subsequently died of colitis. By one year after transplantation, four patients relapsed after taking antibiotics for unrelated causes; two of these were treated with a second fecal transplantation procedure and two with antibiotics for CDI. There were no immediate complications of fecal transplantation found in the cohort.

"The results of fecal transplantation appear to be clearly better than any other treatment for recurrent CDI. Fortunately, refractory recurrent cases of CDI are quite rare compared with all of CDI cases. Even though fecal transplantation is not simple to perform and it has potential risks, fecal transplantation is an effective option for the treatment of recurrent CDI," the authors write.

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Recommended for you

Researchers discover target for treating dengue fever

1 hour ago

Two recent papers by a University of Colorado School of Medicine researcher and colleagues may help scientists develop treatments or vaccines for Dengue fever, West Nile virus, Yellow fever, Japanese encephalitis and other ...

Tracking flu levels with Wikipedia

1 hour ago

Can monitoring Wikipedia hits show how many people have the flu? Researchers at Boston Children's Hospital, USA, have developed a method of estimating levels of influenza-like illness in the American population by analysing ...

User comments