Fecal transplant feasible for recurrent <i>C. difficile</i> infection

Fecal transplant feasible for recurrent <i>C. difficile</i> infection

(HealthDay) -- Recurrent Clostridium difficile (C. difficile) infection (CDI) can successfully be treated in the vast majority of patients through a fecal transplantation procedure via colonoscopy, according to research published in the March issue of Gastroenterology.

Eero Mattila, M.D., of the Helsinki University Central Hospital, and colleagues reviewed for 70 patients with recurrent CDI who had undergone a fecal transplantation procedure in which fresh donor feces were infused into the cecum via after whole-bowel lavage with .

The researchers found that, during the first 12 weeks post-transplantation, all patients without infection with strain 027 C. difficile, and 89 percent of the 36 patients infected with the 027 strain, had symptom resolution. All non-responders had a pre-existing serious condition and subsequently died of colitis. By one year after transplantation, four patients relapsed after taking antibiotics for unrelated causes; two of these were treated with a second fecal transplantation procedure and two with antibiotics for CDI. There were no immediate complications of fecal transplantation found in the cohort.

"The results of fecal transplantation appear to be clearly better than any other treatment for recurrent CDI. Fortunately, refractory recurrent cases of CDI are quite rare compared with all of CDI cases. Even though fecal transplantation is not simple to perform and it has potential risks, fecal transplantation is an effective option for the treatment of recurrent CDI," the authors write.

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Recommended for you

Filipino tests negative for Middle East virus

10 hours ago

A Filipino nurse who tested positive for the Middle East virus has been found free of infection in a subsequent examination after he returned home, Philippine health officials said Saturday.

US orders farms to report pig virus infections

Apr 18, 2014

The U.S. government is starting a new program to help monitor and possibly control the spread of a virus that has killed millions of pigs since showing up in the country last year.

Foreigner dies of MERS in Saudi

Apr 18, 2014

A foreigner has died after she contracted MERS in the Saudi capital, the health ministry said on announced Friday, bringing the nationwide death toll to 73.

Vietnam battles fatal measles outbreak

Apr 18, 2014

Vietnam is scrambling to contain a deadly outbreak of measles that has killed more than 100 people, mostly young children, and infected thousands more this year, the government said Friday.

New clues on tissue scarring in scleroderma

Apr 18, 2014

A discovery by Northwestern Medicine scientists could lead to potential new treatments for breaking the cycle of tissue scarring in people with scleroderma.

User comments