Gestational diabetes, obesity impact pregnancy outcomes

March 2, 2012
Gestational diabetes, obesity impact pregnancy outcomes

(HealthDay) -- Women with gestational diabetes mellitus (GDM) who are obese have significantly higher odds of adverse pregnancy outcomes, according to findings from the multinational Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study published online Feb. 22 in Diabetes Care.

To determine associations of GDM and obesity with adverse outcomes, Patrick M. Catalano, M.D., of Case Western Reserve University at MetroHealth Medical Center in Cleveland, and associates analyzed HAPO data on 23,316 women (average age, 29.2 years) from 15 centers in nine countries who took a 75-g oral glucose tolerance test (OGTT) between 24 and 32 weeks of pregnancy.

The researchers found that obesity, defined as (BMI) ≥33.0 kg/m², and GDM were diagnosed in 13.7 and 16.1 percent of participants, respectively, with an odds ratio (OR) of 2.19 for birth weight greater than 90th percentile for GDM alone, compared with obesity alone (OR, 1.73) and GDM and obesity combined (OR, 3.62). The data showed that women with higher OGTT glucose and maternal BMI had significantly higher odds for newborn body fat, cord serum C-peptide, and birth weight greater than 90th percentile compared to normal/underweight women (64.2 percent of participants) with normal glucose.

"Both maternal GDM and obesity are independently associated with adverse ," the authors write. "Their combination has a greater impact than either one alone."

Explore further: Weight gain between first and second pregnancies increases woman's gestational diabetes risk

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Recommended for you

Drug prevents type 1 diabetes in mice, study finds

September 14, 2015

The buildup of a substance in the pancreas during the pre-symptomatic stage of Type 1 diabetes is essential to the development of the disease, Stanford University School of Medicine researchers have shown.

Bacteria may cause type 2 diabetes

June 1, 2015

Bacteria and viruses have an obvious role in causing infectious diseases, but microbes have also been identified as the surprising cause of other illnesses, including cervical cancer (Human papilloma virus) and stomach ulcers ...

Engineered hot fat implants reduce weight gain in mice

August 20, 2015

Scientists at the University of California, Berkeley, have developed a novel way to engineer the growth and expansion of energy-burning "good" fat, and then found that this fat helped reduce weight gain and lower blood glucose ...


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.