Misoprostol substantially reduces serious complications in early termination of pregnancy
Cervical preparation with misoprostol reduces major complications of early surgical abortion by almost a third compared with placebo, according to new research published Online First in The Lancet.
Misoprostol is commonly used for cervical preparation prior to surgical abortion (vacuum aspiration) because it is effective, widely available, easy to use, and cheap. But until now, no studies have been large enough to assess whether misoprostol affects the occurrence of immediate or delayed (a few weeks after) serious complications from surgical abortion.
In this study, Eduardo Bergel from WHO, Geneva, Switzerland and colleagues compared rates of complications (cervical tear, uterine perforation, incomplete abortion, pelvic inflammatory disease, or any other serious event) of vacuum aspirations. 4972 women requesting a termination of early pregnancy (before 12 weeks gestation) from 14 centres in nine countries were randomly assigned to vaginal misoprostol (2485 women) or placebo (2487 women) 3 hours before aspiration.
Women given misoprostol were nearly a third less likely to experience one complication or more compared to those receiving placebo. Additionally, the risk of incomplete abortion was almost three times higher in the placebo group than in the misoprostol group. Minor cervical tears and uterine perforations were also less common in the misoprostol group.
Abdominal pain, vaginal bleeding, and nausea were more frequent after treatment with misoprostol during the 3 hours prior to surgery. But no differences in the incidences of pelvic inflammatory disease or other serious adverse events were noted between the groups.
The authors conclude: "Misoprostol reduced the overall incidence of complications, particularly incomplete abortions and unscheduled clinic visits and hospital admissions after abortion Providers should be aware of the side-effects of the drug and inform women about these effects."
In an accompanying Comment, Allan Templeton from the University of Aberdeen in Scotland says: "The important issue is the balance between effectiveness of the procedure and the side-effects of misoprostol, which will include abdominal cramps and vaginal bleeding in most women, although not to the extent of needing medical intervention before surgery."
In light of these new findings he adds: "Surely routine pharmaceutical dilation of the cervix should be recommended as an integral part of surgical abortion in all women."
Provided by Lancet
- Abortion drug's off-label use may have led to deaths Jun 16, 2008 | not rated yet | 0
- Abortion pill used in a quarter of US abortions Jul 08, 2009 | not rated yet | 0
- No decline in US abortion rate Jan 11, 2011 | not rated yet | 0
- Report: Abortion laws don't stop abortions Oct 13, 2007 | not rated yet | 0
- First-trimester induced abortion not associated with increased risk of psychiatric readmission Feb 06, 2012 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
Find a link between physics and assignment problems
1 hour ago Hi ! I've been working about assignments problems and how to solve them. I will have to do a presentation about it in few weeks. However, I'll...
Light as a source of electricity
1 hour ago Hello Dear Fellows! We all know that light is an electromagnetic wave and also we know that an antenna receives EM waves and...
A question about the energy stored in a capacitor.
1 hour ago If we imagine a simple circuit with a battery and a capacitor with negligible internal resistance, the capacitor is charged up to a point where the...
Electric field-Charge inside a metallic shell
3 hours ago I am having few doubts while studying electric field which i am putting here Suppose there is a spherical metallic shell with point charge q1 at...
Change in momentum when a body is thrown up and falls back down.
10 hours ago Say, a body of mass 'm' is thrown at a certain angle with the vertical with certain initial velocity 'u'. The initial momentum of this object is mu....
change in speed and wavelength of light while travelling from one med
10 hours ago what is the mechanism by which light changes its speed and wavelength while travelling from one medium to other. I know it is c/n or lamda/n and know...
- More from Physics Forums - Classical Physics
More news stories
New research indicates that women's reproductive function may be tied to their immune status. Previous studies have found this association in human males, but not females.
Obstetrics & gynaecology May 17, 2013 | not rated yet | 0 |
Elsevier today announced the publication of a recent study in Reproductive BioMedicine Online on 5-day old human blastocysts showing that those with an abnormal chromosomal composition can be identified by the rate at whic ...
Obstetrics & gynaecology May 16, 2013 | not rated yet | 0
While global attention has for decades been focused on reducing maternal mortality, population-based data on other causes of death among women of reproductive age has been virtually non-existent. A study conducted by researchers ...
Obstetrics & gynaecology May 14, 2013 | not rated yet | 0
Doctors have terminated the pregnancy of a 23-year-old Turkish woman who was the first ever to receive a uterus transplant from a dead donor, a hospital in southern Turkey said on Tuesday.
Obstetrics & gynaecology May 14, 2013 | not rated yet | 0
Researchers at the University of Wisconsin have identified a potential new risk factor for obstructive sleep apnea: asthma. Using data from the National Institutes of Health (Heart, Lung, and Blood Institute)-funded Wisconsin ...
25 minutes ago | not rated yet | 0 |
A new study looking at sleep-disordered breathing (SDB) and markers for Alzheimer's disease (AD) risk in cerebrospinal fluid (CSF) and neuroimaging adds to the growing body of research linking the two.
35 minutes ago | not rated yet | 0 |
Gourmands and foodies everywhere have long recognized ginger as a great way to add a little peppery zing to both sweet and savory dishes; now, a study from researchers at Columbia University shows purified components of the ...
25 minutes ago | not rated yet | 0
In their quest to learn more about the variability of cells between and within tissues, biomedical scientists have devised tools capable of simultaneously measuring dozens of characteristics of individual ...
1 hour ago | not rated yet | 0 |
Scientists at Johns Hopkins have turned their view of osteoarthritis (OA) inside out. Literally. Instead of seeing the painful degenerative disease as a problem primarily of the cartilage that cushions joints, ...
1 hour ago | 5 / 5 (1) | 0 |
The hunt for an HIV vaccine has gobbled up $8 billion in the past decade, and the failure of the most recent efficacy trial has delivered yet another setback to 26 years of efforts.
5 hours ago | not rated yet | 0