Prophylaxis with apixaban feasible for cancer patients
Primary venous thromboembolism prophylaxis with apixaban, an oral direct Factor Xa inhibitor, in ambulatory cancer patients undergoing first- or second-line chemotherapy for advanced or metastatic cancer, is safe and well tolerated, according to a phase II study published online March 12 in the Journal of Thrombosis and Haemostasis.
(HealthDay) -- Primary venous thromboembolism prophylaxis with apixaban, an oral direct Factor Xa inhibitor, in ambulatory cancer patients undergoing first- or second-line chemotherapy for advanced or metastatic cancer, is safe and well tolerated, according to a phase II study published online March 12 in the Journal of Thrombosis and Haemostasis.
Mark N. Levine, M.D., of McMaster University in Hamilton, Canada, and colleagues conducted a randomized phase II trial of oral apixaban in patients with advanced or metastatic lung, breast, gastrointestinal, bladder, ovarian, myeloma, or prostate cancers. Subjects receiving either first- or second-line chemotherapy were randomized to 5 mg (32 patients), 10 mg (30 patients), or 20 mg (33 patients) once a day of apixaban or placebo (30 patients) for 12 weeks. Administration of the study drug began within four weeks of chemotherapy initiation.
The researchers found that there were no major bleeds for those taking 5 mg or 10 mg apixaban, two major bleeds among patients taking 20 mg, and one major bleed in the placebo group. The corresponding numbers of clinically relevant non-major bleeds were one, one, two, and zero. There was a 2.2 percent rate of major bleeding in the apixaban patients, with no fatal bleeds. Three patients in the placebo group had symptomatic venous thromboembolism (VTE).
"These results support further study of apixaban in Phase III trials to prevent VTE in cancer patients on chemotherapy," the authors write.
The study was funded by Bristol-Myers Squibb and Pfizer Inc., which manufacture apixaban; two authors are employed by Bristol-Myers Squibb.
More information: Abstract
Full Text (subscription or payment may be required)
Copyright © 2012 HealthDay. All rights reserved.
-
Final data show experimental agent better than aspirin at preventing stroke
Feb 10, 2011 |
not rated yet |
0
-
Apixaban superior to warfarin for preventing stroke, reducing bleeding and saving lives
Aug 28, 2011 |
not rated yet |
0
-
Widely used cancer drug associated with significantly increased risk of blood clots
Nov 18, 2008 |
not rated yet |
0
-
More advantages found for new drug: study
Feb 10, 2011 |
not rated yet |
0
-
Success stops drug trial
Aug 31, 2010 |
not rated yet |
0
-
Motion perception revisited: High Phi effect challenges established motion perception assumptions
Apr 23, 2013 |
3 / 5 (2) |
2
-
Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update)
Apr 02, 2013 |
4.5 / 5 (11) |
5
-
The visual system as economist: Neural resource allocation in visual adaptation
Mar 30, 2013 |
5 / 5 (2) |
9
-
Separate lives: Neuronal and organismal lifespans decoupled
Mar 27, 2013 |
4.9 / 5 (8) |
0
-
Sizing things up: The evolutionary neurobiology of scale invariance
Feb 28, 2013 |
4.8 / 5 (10) |
14
-
How can there be villous adenoma in colon, if there are no villi there
14 hours ago
-
How can there be a term called "intestinal metaplasia" of stomach
May 21, 2013
-
Pressure-volume curve: Elastic Recoil Pressure don't make sense
May 18, 2013
-
If you became brain-dead, would you want them to pull the plug?
May 17, 2013
-
MRI bill question
May 15, 2013
-
Ratio of Hydrogen of Oxygen in Dessicated Animal Protein
May 13, 2013
- More from Physics Forums - Medical Sciences
More news stories
American cancer society celebrates 100 years of progress
(HealthDay)—The American Cancer Society, which is celebrating on Wednesday a century of fighting a disease once viewed as a death sentence, is making a pledge to put itself out of business.
Cancer
4 hours ago |
not rated yet |
0
CT detects twice as many lung cancers as X-ray at initial screening exam
National Lung Screening Trial (NLST) investigators also conclude that the 20 percent reduction in lung cancer mortality with low-dose computed tomography (LDCT) versus chest X-ray (CXR) screening previously reported in the ...
Cancer
4 hours ago |
not rated yet |
0
Research offers promising new approach to treatment of lung cancer
Researchers have developed a new drug delivery system that allows inhalation of chemotherapeutic drugs to help treat lung cancer, and in laboratory and animal tests it appears to reduce the systemic damage ...
Cancer
7 hours ago |
not rated yet |
0
|
Study details genes that control whether tumors adapt or die when faced with p53 activating drugs
When turned on, the gene p53 turns off cancer. However, when existing drugs boost p53, only a few tumors die – the rest resist the challenge. A study published in the journal Cell Reports shows how: tumors that live even i ...
Cancer
8 hours ago |
not rated yet |
0
|
Small increase in cancer risk following CT scans in childhood and adolescence
Study leader, Professor John Mathews from the University of Melbourne said this small increase in cancer risk must be weighed against the undoubted benefits from CT scans in diagnosing and monitoring disease.
Cancer
12 hours ago |
not rated yet |
0
Slowing the aging process—only with antibiotics
Swiss scientists reveal the mechanism responsible for aging hidden deep within mitochondria—and dramatically slow it down in worms by administering antibiotics to the young.
Researchers complete largest genetic sequencing study of human disease
Researchers from Queen Mary, University of London have led the largest sequencing study of human disease to date, investigating the genetic basis of six autoimmune diseases.
Brain can be trained in compassion, study shows
Until now, little was scientifically known about the human potential to cultivate compassion—the emotional state of caring for people who are suffering in a way that motivates altruistic behavior.
Having both migraines, depression may mean smaller brain
(HealthDay)—Migraines and depression can each cause a great deal of suffering, but new research indicates the combination of the two may be linked to something else entirely—a smaller brain.
Novel approach for influenza vaccination shows promise in early animal testing
A new approach for immunizing against influenza elicited a more potent immune response and broader protection than the currently licensed seasonal influenza vaccines when tested in mice and ferrets. The vaccine ...
Enzyme-activating antibodies revealed as marker for most severe form of rheumatoid arthritis
In a series of lab experiments designed to unravel the workings of a key enzyme widely considered a possible trigger of rheumatoid arthritis, researchers at Johns Hopkins have found that in the most severe ...
